PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33262140-10	2021	At the MTD olaparib reduced PAR levels by over 95% and abolished radiation-induced PARylation.	olaparib	11-19	jumping translocation breakpoint	Homo sapiens	28-31	
24038812-8	2014	RESULTS: Olaparib induced growth inhibition, median (range) IC50 = 3.6 (1-33.8) microM, and inhibited PAR activity in pediatric solid tumor cell lines.	olaparib	9-17	jumping translocation breakpoint	Homo sapiens	102-105	
27686740-0	2016	Efficacy of poly (ADP-ribose) polymerase inhibitor olaparib against head and neck cancer cells: Predictions of drug sensitivity based on PAR-p53-NF-kappaB interactions.	olaparib	51-59	jumping translocation breakpoint	Homo sapiens	137-140	
27686740-7	2016	We found that basal poly (ADP-ribose) (PAR) levels, but not PARP-1 levels, correlated with olaparib sensitivity.	olaparib	91-99	jumping translocation breakpoint	Homo sapiens	39-42	
27686740-10	2016	As interference with p53 expression led to NF-kappaB reactivation, we concluded that elevated basal PAR and NF-kappaB levels are predictive of olaparib responsiveness in HNC cells; in addition, olaparib inhibits HNC cells via PAR-p53-NF-kappaB interactions.	olaparib	143-151	jumping translocation breakpoint	Homo sapiens	100-103	
27686740-10	2016	As interference with p53 expression led to NF-kappaB reactivation, we concluded that elevated basal PAR and NF-kappaB levels are predictive of olaparib responsiveness in HNC cells; in addition, olaparib inhibits HNC cells via PAR-p53-NF-kappaB interactions.	olaparib	194-202	jumping translocation breakpoint	Homo sapiens	226-229	
25981132-6	2015	Olaparib concentrations that resulted in radiosensitization prevented PAR induction by irradiation.	olaparib	0-8	jumping translocation breakpoint	Homo sapiens	70-73	
24038812-10	2014	In RD-ES and NGP xenografts, olaparib inhibited PAR activity by 88-100% as a single agent and 100% when administered with cyclophosphamide/topotecan.	olaparib	29-37	jumping translocation breakpoint	Homo sapiens	48-51