PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25322900-6	2014	In the lowest cobalamin quartile (<=273 pmol/L), riboflavin status modifies the relationship between the MTRR 66 A>G polymorphism and tHcy (p for interaction: 0.034).	thcy	140-144	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	108-112	
25322900-7	2014	tHcy was 6.6 % higher in MTRR 66G allele carriers compared to the 66AA genotype with marginally deficient or optimal riboflavin status, but there was no difference when riboflavin status was deficient (p for interaction: 0.059).	thcy	0-4	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	25-29	
25322900-8	2014	tHcy was 13.7 % higher in MTRR 524T allele carriers compared to the 524CC genotype when cobalamin status was low (p < 0.01), but no difference was observed when we stratified by riboflavin status.	thcy	0-4	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	26-30	
25322900-9	2014	The effect of the MTHFR 677C>T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A>G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C>T polymorphism on cobalamin status.	thcy	50-54	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	175-179	
19394322-4	2009	RESULTS: MTHFR 677T, MTRR 66A, GCPII 1561T, male gender, alcohol intake, smoking, diabetes, creatinine and hypertension were found to influence tHcy.	thcy	144-148	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	21-25	
17522601-12	2008	The interaction between low levels of serum Cbl and MTHFR (C677T or A1298C) or MTRR A66G gene polymorphisms was associated with increased tHcy.	thcy	138-142	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	79-83	
11472746-10	2001	This study provides the first evidence that the MTRR A66G polymorphism significantly influences the circulating tHcy concentration.	thcy	112-116	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	48-52	
18774994-8	2008	The MTRR 66GG and MTHFR 1298 CC genotypes may confer protection against early nephropathy, possibly because they are associated with lower tHcy.	thcy	139-143	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	4-8	
17611986-1	2007	OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.	thcy	323-327	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	77-106	
17611986-1	2007	OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.	thcy	323-327	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	108-111