PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33375456-12 2020 The MTHFR polymorphism was significantly correlated with higher total cholesterol (TC) (p = 0.023), low- density lipoprotein cholesterol (LDL) (p = 0.008), homocysteine level (tHcy) (p < 0.001). thcy 176-180 methylenetetrahydrofolate reductase Homo sapiens 4-9 31044529-8 2020 CONCLUSIONS: This study suggests that choline and folate intakes might interact with MTHFR, BHMT and PEMT polymorphisms to determine tHcy and GSH blood concentrations in healthy pregnant women. thcy 133-137 methylenetetrahydrofolate reductase Homo sapiens 85-90 32992197-10 2020 Higher plasma tHcy level was also associated with number of CMBs, TT MTHFR genotype, and lower MMSE scores. thcy 14-18 methylenetetrahydrofolate reductase Homo sapiens 69-74 32992197-12 2020 Lowering plasma tHcy could be helpful in cognitively impaired patients who have CMBs or the MTHFR TT genotype. thcy 16-20 methylenetetrahydrofolate reductase Homo sapiens 92-97 32127061-6 2020 Medical history and lifestyle habits were recorded.Principal tHcy determinants differed between women (age, plasma folate, plasma cobalamin, cigarettes/day) and men (MTHFR 677TT genotype, plasma folate, plasma cobalamin and CT genotype). thcy 61-65 methylenetetrahydrofolate reductase Homo sapiens 166-171 32299541-1 2020 Objective To investigate the association between total homocysteine (tHcy) level in plasma and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genetic polymorphisms in a Chinese Han nationality population with type 2 diabetes mellitus (T2DM) accompanied by dyslipidemia. thcy 69-73 methylenetetrahydrofolate reductase Homo sapiens 95-130 32299541-1 2020 Objective To investigate the association between total homocysteine (tHcy) level in plasma and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genetic polymorphisms in a Chinese Han nationality population with type 2 diabetes mellitus (T2DM) accompanied by dyslipidemia. thcy 69-73 methylenetetrahydrofolate reductase Homo sapiens 132-137 32299541-8 2020 There was a significant correlation between tHcy level and MTHFR C677T gene polymorphism in T2DM patients (t=2.27, P=0.02). thcy 44-48 methylenetetrahydrofolate reductase Homo sapiens 59-64 32299541-10 2020 Conclusion MTHFR 677TT genotype might associate with higher tHcy level in T2DM patients with dyslipidemia. thcy 60-64 methylenetetrahydrofolate reductase Homo sapiens 11-16 32127061-7 2020 The MTHFR 677C>T polymorphism-tHcy association (beta standardised regression coefficients) was stronger in male smokers (0.52, P < 0.001) compared to nonsmokers (0.21, P = 0.001) and weaker in participants >50 (0.19, P = 0.007) compared to <=50 years (0.31, P < 0.001). thcy 30-34 methylenetetrahydrofolate reductase Homo sapiens 4-9 29813097-1 2018 AIMS: To study how MTHFR 677C T genotype modulates the effect of supplementation with B-vitamins on total homocysteine (tHcy) and B-vitamin concentrations. thcy 120-124 methylenetetrahydrofolate reductase Homo sapiens 19-24 30080444-2 2019 Previously, it has been shown that the common c.677C > T polymorphism in MTHFR influences global DNA methylation status through a direct interaction with folate status and (indirectly) with total homocysteine (tHcy) levels. thcy 213-217 methylenetetrahydrofolate reductase Homo sapiens 76-81 30401001-5 2018 The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status. thcy 14-18 methylenetetrahydrofolate reductase Homo sapiens 120-125 29371246-5 2018 More importantly, tHcy lowering varied by MTHFR genotypes and serum folate levels. thcy 18-22 methylenetetrahydrofolate reductase Homo sapiens 42-47 29722849-1 2018 Background: The single nucleotide polymorphism of the gene 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (or rs1801133) is the most established genetic factor that increases plasma total homocysteine (tHcy) and consequently results in hyperhomocysteinemia. thcy 210-214 methylenetetrahydrofolate reductase Homo sapiens 59-99 29722849-1 2018 Background: The single nucleotide polymorphism of the gene 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (or rs1801133) is the most established genetic factor that increases plasma total homocysteine (tHcy) and consequently results in hyperhomocysteinemia. thcy 210-214 methylenetetrahydrofolate reductase Homo sapiens 101-106 29444504-12 2018 In addition, patients carrying the MTHFR rs915014 AG or GG genotypes were associated with accumulation of circulating tHcy volume and a poor atherosclerosis consequence. thcy 118-122 methylenetetrahydrofolate reductase Homo sapiens 35-40 28963520-8 2017 In addition, the total homocysteine (tHcy) levels in subjects with MTHFR 2572AA were elevated compared to tHcy levels in subjects with MTHFR 2572CC. thcy 37-41 methylenetetrahydrofolate reductase Homo sapiens 67-72 29030456-10 2017 The beneficial effect associated with greater tHcy reduction was observed across strata for age, sex, treatment group (with vs without folic acid), MTHFR C677T genotypes, baseline tHcy and serum folate levels, and blood pressure control. thcy 46-50 methylenetetrahydrofolate reductase Homo sapiens 148-153 28171870-10 2017 In addition, patients carrying the MTHFR rs868014 TC or CC genotypes were associated with accumulation of serum tHcy and a poor ischemic stroke outcome. thcy 112-116 methylenetetrahydrofolate reductase Homo sapiens 35-40 28598562-5 2017 Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T. thcy 28-32 methylenetetrahydrofolate reductase Homo sapiens 102-142 28598562-5 2017 Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T. thcy 28-32 methylenetetrahydrofolate reductase Homo sapiens 144-149 28598562-10 2017 Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 55-60 28381531-4 2017 Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees. thcy 238-242 methylenetetrahydrofolate reductase Homo sapiens 151-191 28381531-4 2017 Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees. thcy 238-242 methylenetetrahydrofolate reductase Homo sapiens 193-198 28381531-4 2017 Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees. thcy 307-311 methylenetetrahydrofolate reductase Homo sapiens 151-191 28381531-4 2017 Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees. thcy 307-311 methylenetetrahydrofolate reductase Homo sapiens 193-198 28094233-8 2017 Individuals with the MTHFR TT genotype had significantly higher serum tHcy concentrations than individuals with the CC and CT genotypes (p<0.001). thcy 70-74 methylenetetrahydrofolate reductase Homo sapiens 21-26 28094233-11 2017 CONCLUSION: The MTHFR C677T polymorphism, folate deficiency, and B12 deficiency were significantly associated with elevated serum tHcy levels. thcy 130-134 methylenetetrahydrofolate reductase Homo sapiens 16-21 28094233-13 2017 Thus, folic acid and vitamin B12 supplementation could help prevent diseases associated with tHcy accumulation, especially in individuals with the MTHFR 677TT genotype. thcy 93-97 methylenetetrahydrofolate reductase Homo sapiens 147-152 28225483-9 2017 Potential effect modification by the MTHFR genotype on the relationship between tHcy and all-cause mortality was tested. thcy 80-84 methylenetetrahydrofolate reductase Homo sapiens 37-42 28225483-16 2017 Whereas the MTHFR genotype alone had little effect on mortality, it significantly modified the tHcy-mortality association, which was much stronger in the CC/CT genotype than in the TT genotype (P for interaction < 0.05). thcy 95-99 methylenetetrahydrofolate reductase Homo sapiens 12-17 28225483-17 2017 CONCLUSIONS: Among Chinese hypertensive patients without cardiovascular comorbidities, elevated tHcy was a significant risk marker for death from all causes, and the association was subject to effect modification by MTHFR genotypes. thcy 96-100 methylenetetrahydrofolate reductase Homo sapiens 216-221 27293558-9 2016 Subjects with the methylenetetrahydrofolate reductase mutations CT and TT had 11 % (P < 0 05) higher baseline tHcy concentrations than those with the wild-type CC. thcy 113-117 methylenetetrahydrofolate reductase Homo sapiens 18-53 26559681-3 2016 The aim of our study was to explore the response of tHcy in hemodialysis (HD) patients to individual supplementation with folic acid (B9) and/or vitamin B12, based on carrier status for the (MTHFR) polymorphism. thcy 52-56 methylenetetrahydrofolate reductase Homo sapiens 191-196 26559681-16 2016 CONCLUSION: Supplementation with B vitamins correlated to the MTHFR genotypes has been shown to lower significantly tHcy in HD patients. thcy 116-120 methylenetetrahydrofolate reductase Homo sapiens 62-67 24183735-3 2013 The role of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene (MTHFR) on the increase of plasma tHcy in patients with epilepsy taking AEDs is still controversial. thcy 121-125 methylenetetrahydrofolate reductase Homo sapiens 46-81 26750749-4 2016 This study investigated the prevalence of CBS mutations and the common methylenetetrahydrofolate reductase (MTHFR) c.677C>T polymorphism in patients with tHcy >= 50 muM and the association with clinical manifestations. thcy 157-161 methylenetetrahydrofolate reductase Homo sapiens 71-106 26750749-12 2016 When tHcy is between 50 and 100 muM genotyping for the MTHFR(3) c.677TT is relevant, and when tHcy >100 muM CBS should be genotyped. thcy 5-9 methylenetetrahydrofolate reductase Homo sapiens 55-60 27051654-5 2016 MTHFR C677T polymorphism was genotyped by the polymerase chain reaction technique combined with restriction enzyme fragment length polymorphism (PCR-RFLP) technique and plasma total homocysteine (tHcy) levels were determined by enzyme immunoassay method. thcy 196-200 methylenetetrahydrofolate reductase Homo sapiens 0-5 27051654-12 2016 Also, MTHFR C677T polymorphism is not a risk factor for PVT but is a contributing factor for elevated plasma tHcy levels. thcy 109-113 methylenetetrahydrofolate reductase Homo sapiens 6-11 25841618-8 2015 The risk of failure in tHcy level normalization was increased in patients with metabolic syndrome (hazard ratio [HR], 3.49; 95% confidence interval [CI], 1.46-8.36), higher baseline tHcy levels (HR, 1.045; 95% CI, 1.018-1.073), or methylenetetrahydrofolate reductase homozygous mutation (HR, 6.59; 95% CI, 2.64-16.4). thcy 23-27 methylenetetrahydrofolate reductase Homo sapiens 231-266 25322900-4 2014 MTHFR 677T allele carriers with middle or low tertile plasma folate (<14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p < 0.01). thcy 103-107 methylenetetrahydrofolate reductase Homo sapiens 0-5 25322900-9 2014 The effect of the MTHFR 677C>T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A>G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C>T polymorphism on cobalamin status. thcy 50-54 methylenetetrahydrofolate reductase Homo sapiens 18-23 24853127-4 2014 The aim of this study is to examine whether genetic variants in MTHFR gene are associated with the risk of ischemic stroke and fasting total serum homocysteine (tHcy) level. thcy 161-165 methylenetetrahydrofolate reductase Homo sapiens 64-69 24853127-8 2014 Besides, the MTHFR rs1801133 and rs9651118 were significantly associated with serum levels of tHcy in healthy controls (p<0.0001 and p=0.02). thcy 94-98 methylenetetrahydrofolate reductase Homo sapiens 13-18 24853127-9 2014 These findings suggest that variants in the MTHFR gene may influence the risk of ischemic stroke and serum tHcy. thcy 107-111 methylenetetrahydrofolate reductase Homo sapiens 44-49 24472005-3 2014 Thus, polymorphisms of MTHFR could potentially contribute to the development of vitiligo by affecting MTHFR activity and tHcy levels. thcy 121-125 methylenetetrahydrofolate reductase Homo sapiens 23-28 26774227-9 2016 MTHFR C677T TT was associated with higher tHcy but did not affect cognitive performance per se. thcy 42-46 methylenetetrahydrofolate reductase Homo sapiens 0-5 26689687-13 2015 Our data indicated that variants in MTHFR gene might individually and jointly influence susceptibility to ARC by affecting MTHFR enzyme activity and tHcy levels. thcy 149-153 methylenetetrahydrofolate reductase Homo sapiens 36-41 26719836-2 2015 The aim of the present study was to investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with plasma total homocysteine (tHcy) levels and DVT risk in an Iranian population. thcy 167-171 methylenetetrahydrofolate reductase Homo sapiens 72-107 26719836-2 2015 The aim of the present study was to investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with plasma total homocysteine (tHcy) levels and DVT risk in an Iranian population. thcy 167-171 methylenetetrahydrofolate reductase Homo sapiens 109-114 26719836-6 2015 Also, plasma tHcy levels were significantly higher in MTHFR 677TT genotypes compared to 677CC genotypes in both DVT patients (P=0.016) and controls (P=0.03). thcy 13-17 methylenetetrahydrofolate reductase Homo sapiens 54-59 26719836-11 2015 Also, MTHFR 677TT genotype is a determinant of elevated plasma tHcy levels. thcy 63-67 methylenetetrahydrofolate reductase Homo sapiens 6-11 25165408-4 2014 The aim of this study is to examine whether polymorphisms in the MTHFR gene are associated with risk of type 2 diabetes mellitus (T2DM) and fasting total serum homocysteine (tHcy) levels. thcy 174-178 methylenetetrahydrofolate reductase Homo sapiens 65-70 25165408-8 2014 Besides, the MTHFR rs1801133 was significantly associated with serum levels of tHcy in healthy controls (P = 0.0002). thcy 79-83 methylenetetrahydrofolate reductase Homo sapiens 13-18 25165408-10 2014 These findings suggest that variants in the MTHFR gene may influence the risk of T2DM and tHcy levels. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 44-49 24183735-3 2013 The role of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene (MTHFR) on the increase of plasma tHcy in patients with epilepsy taking AEDs is still controversial. thcy 121-125 methylenetetrahydrofolate reductase Homo sapiens 88-93 23643559-6 2013 The tHcy concentration was higher in MTHFR TT homozygote individuals than in wild-type CC individuals. thcy 4-8 methylenetetrahydrofolate reductase Homo sapiens 37-42 24498831-2 2013 Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels. thcy 298-302 methylenetetrahydrofolate reductase Homo sapiens 82-122 24498831-2 2013 Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels. thcy 298-302 methylenetetrahydrofolate reductase Homo sapiens 124-129 24498831-6 2013 Moreover, as the multiple linear regression analysis indicated, smoking habit, folate levels and the MTHFR Val/Val genotype were the only major predictors of tHcy concentrations in the current investigation. thcy 158-162 methylenetetrahydrofolate reductase Homo sapiens 101-106 24167429-7 2013 Multiple regression analysis has shown that tHcy level in CT and TT genotypes of MTHFR (C677T) was statistically higher in comparison with CC genotype of MTHFR (C677T) in both, the control group and the DVT patients. thcy 44-48 methylenetetrahydrofolate reductase Homo sapiens 81-86 22676332-1 2013 We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. thcy 87-91 methylenetetrahydrofolate reductase Homo sapiens 72-77 22676332-4 2013 We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age. thcy 69-73 methylenetetrahydrofolate reductase Homo sapiens 46-51 24051386-2 2013 The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. thcy 133-137 methylenetetrahydrofolate reductase Homo sapiens 147-152 24167429-7 2013 Multiple regression analysis has shown that tHcy level in CT and TT genotypes of MTHFR (C677T) was statistically higher in comparison with CC genotype of MTHFR (C677T) in both, the control group and the DVT patients. thcy 44-48 methylenetetrahydrofolate reductase Homo sapiens 154-159 22782530-1 2012 The methylenetetrahydrofolate reductase (MTHFR) 677 C T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. thcy 121-125 methylenetetrahydrofolate reductase Homo sapiens 4-39 22770603-6 2012 Men with the MTHFR TT homozygosity had significantly higher tHcy concentration than those with the CC genotype (mean difference of 1.38 mumol/l, 95% CI 0.77-1.99). thcy 60-64 methylenetetrahydrofolate reductase Homo sapiens 13-18 22782530-1 2012 The methylenetetrahydrofolate reductase (MTHFR) 677 C T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. thcy 121-125 methylenetetrahydrofolate reductase Homo sapiens 41-46 22425007-3 2012 The present study aimed to assess the role of antiepileptic drugs (AEDs) and C677T methylenetetrahydrofolate (MTHFR) polymorphisms on tHcy in pediatric patients with epilepsy treated for at least 6 months with various treatment regimens protocols including the newer AEDs. thcy 134-138 methylenetetrahydrofolate reductase Homo sapiens 110-115 22897803-3 2012 The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese. thcy 183-187 methylenetetrahydrofolate reductase Homo sapiens 63-98 22897803-3 2012 The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese. thcy 183-187 methylenetetrahydrofolate reductase Homo sapiens 100-105 21358708-2 2012 The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase gene (MTHFR) increases basal tHcy, but its contribution to cognitive impairment has not been established. thcy 100-104 methylenetetrahydrofolate reductase Homo sapiens 35-70 22084937-1 2012 In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome. thcy 281-285 methylenetetrahydrofolate reductase Homo sapiens 61-96 22084937-1 2012 In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome. thcy 281-285 methylenetetrahydrofolate reductase Homo sapiens 98-103 22084937-6 2012 The MTHFR 677 TT genotype has decreasing effect in B12 vitamin and increasing effect in tHcy. thcy 88-92 methylenetetrahydrofolate reductase Homo sapiens 4-9 21358708-2 2012 The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase gene (MTHFR) increases basal tHcy, but its contribution to cognitive impairment has not been established. thcy 100-104 methylenetetrahydrofolate reductase Homo sapiens 77-82 21358708-3 2012 We designed this study to determine if tHcy is causally related to cognitive impairment in later life by investigating its association with high tHcy and the MTHFR-C677T polymorphism. thcy 39-43 methylenetetrahydrofolate reductase Homo sapiens 158-163 21669453-4 2011 RESULTS: Baseline; tHcy was highest in MTHFR++ carriers (p < 0,05); 8-iso-PGF(2alpha) and 11-dehydro-TXB(2) levels were independent of sex, MTHFR++ and/or CBSins + (p > 0.05). thcy 19-23 methylenetetrahydrofolate reductase Homo sapiens 39-44 22507617-2 2012 The gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) is reported to be a genetic factor for influencing tHcy. thcy 120-124 methylenetetrahydrofolate reductase Homo sapiens 25-60 22507617-2 2012 The gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) is reported to be a genetic factor for influencing tHcy. thcy 120-124 methylenetetrahydrofolate reductase Homo sapiens 62-67 22507617-8 2012 Therefore, MTHFR genotypes were proven to be a significant determinant for folate and tHcy concentrations. thcy 86-90 methylenetetrahydrofolate reductase Homo sapiens 11-16 21746742-2 2012 The C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) increases tHcy and provides a means of studying the association between tHcy and dementia while not being as susceptible to the common biases and confounding of observational studies. thcy 94-98 methylenetetrahydrofolate reductase Homo sapiens 77-82 21746742-2 2012 The C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) increases tHcy and provides a means of studying the association between tHcy and dementia while not being as susceptible to the common biases and confounding of observational studies. thcy 156-160 methylenetetrahydrofolate reductase Homo sapiens 77-82 21669453-4 2011 RESULTS: Baseline; tHcy was highest in MTHFR++ carriers (p < 0,05); 8-iso-PGF(2alpha) and 11-dehydro-TXB(2) levels were independent of sex, MTHFR++ and/or CBSins + (p > 0.05). thcy 19-23 methylenetetrahydrofolate reductase Homo sapiens 143-148 21669453-6 2011 Mean PML tHcy was maximal in MTHFR++ carriers (p = 0.000). thcy 9-13 methylenetetrahydrofolate reductase Homo sapiens 29-34 20544798-9 2010 In Caucasian women, tHcy concentrations were not associated with total folate levels, but were associated (p < 0.05) with RBC THF, ratios of RBC 5-MTHF:THF, and polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) and MTR. thcy 20-24 methylenetetrahydrofolate reductase Homo sapiens 181-221 20530057-1 2010 Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration. thcy 214-218 methylenetetrahydrofolate reductase Homo sapiens 88-123 20530057-1 2010 Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration. thcy 214-218 methylenetetrahydrofolate reductase Homo sapiens 125-130 20097536-1 2010 OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. thcy 249-253 methylenetetrahydrofolate reductase Homo sapiens 151-186 20097536-1 2010 OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. thcy 249-253 methylenetetrahydrofolate reductase Homo sapiens 188-193 20097536-14 2010 Also, consumption of folate-fortified foods modulates the association of the MTHFR 677C>T polymorphism with tHcy, suggesting that habitual consumption of folate-fortified foods is a practical approach in providing consistent protection to those children who may benefit the most, i.e., carriers of the TT genotype. thcy 111-115 methylenetetrahydrofolate reductase Homo sapiens 77-82 20544798-9 2010 In Caucasian women, tHcy concentrations were not associated with total folate levels, but were associated (p < 0.05) with RBC THF, ratios of RBC 5-MTHF:THF, and polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) and MTR. thcy 20-24 methylenetetrahydrofolate reductase Homo sapiens 223-228 20670473-3 2010 C677T polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have impacts on tHcy level; it is suspected to influence cognitive function, but only few investigations have assessed its effects on non-dementia adults and the results have been controversial. thcy 97-101 methylenetetrahydrofolate reductase Homo sapiens 27-67 20670473-3 2010 C677T polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have impacts on tHcy level; it is suspected to influence cognitive function, but only few investigations have assessed its effects on non-dementia adults and the results have been controversial. thcy 97-101 methylenetetrahydrofolate reductase Homo sapiens 69-74 20670473-9 2010 Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function. thcy 146-150 methylenetetrahydrofolate reductase Homo sapiens 31-36 20670473-9 2010 Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function. thcy 276-280 methylenetetrahydrofolate reductase Homo sapiens 31-36 19909787-3 2010 The contemporary occurrence of C677T polymorphism in homozygosity, leading to a temperature-labile variant of the MTHFR enzyme, induces an even more marked increase in tHcy. thcy 168-172 methylenetetrahydrofolate reductase Homo sapiens 114-119 20113291-1 2010 The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen. thcy 191-195 methylenetetrahydrofolate reductase Homo sapiens 21-63 20113291-1 2010 The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen. thcy 191-195 methylenetetrahydrofolate reductase Homo sapiens 65-70 19654594-4 2009 In addition, the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is an important determinant of elevated tHcy. thcy 120-124 methylenetetrahydrofolate reductase Homo sapiens 17-52 19936026-15 2009 CONCLUSION: The TT and AC genotypes of MTHFR C677T and A1298C polymorphisms and the combined genotype TTAC were associated with PCAG in Punjabi subjects of Pakistani origin and correlated with the high serum tHcy levels seen in these patients. thcy 208-212 methylenetetrahydrofolate reductase Homo sapiens 39-44 19654594-4 2009 In addition, the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is an important determinant of elevated tHcy. thcy 120-124 methylenetetrahydrofolate reductase Homo sapiens 54-59 19654594-5 2009 The main objective of the study was to examine the effect of changes in biological risk factors and lifestyle on tHcy in relation to MTHFR C677T genotype. thcy 113-117 methylenetetrahydrofolate reductase Homo sapiens 133-138 19219535-1 2009 BACKGROUND: The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD). thcy 209-213 methylenetetrahydrofolate reductase Homo sapiens 104-138 19394322-4 2009 RESULTS: MTHFR 677T, MTRR 66A, GCPII 1561T, male gender, alcohol intake, smoking, diabetes, creatinine and hypertension were found to influence tHcy. thcy 144-148 methylenetetrahydrofolate reductase Homo sapiens 9-14 23105845-2 2009 Plasma total homocysteine (tHcy) is also influenced by genetic factors such as polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. thcy 27-31 methylenetetrahydrofolate reductase Homo sapiens 100-135 23105845-2 2009 Plasma total homocysteine (tHcy) is also influenced by genetic factors such as polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. thcy 27-31 methylenetetrahydrofolate reductase Homo sapiens 137-142 19372453-7 2009 The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese -3.8+/-4.5, Malay -4.9+/-4.2, and Indian -3.3+/-3.6 micromol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B(12) (vitB(12)) concentrations. thcy 17-21 methylenetetrahydrofolate reductase Homo sapiens 194-199 19219535-1 2009 BACKGROUND: The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD). thcy 209-213 methylenetetrahydrofolate reductase Homo sapiens 140-145 18823966-5 2008 RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG. thcy 18-22 methylenetetrahydrofolate reductase Homo sapiens 52-57 19056652-2 2009 Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. thcy 51-55 methylenetetrahydrofolate reductase Homo sapiens 127-162 19056652-2 2009 Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. thcy 51-55 methylenetetrahydrofolate reductase Homo sapiens 164-169 19056652-5 2009 MTHFR 677TT homozygotes had higher (P < 0.01) tHcy concentrations both before and after fortification compared with MTHFR 677CC homozygotes. thcy 49-53 methylenetetrahydrofolate reductase Homo sapiens 0-5 19211833-1 2009 We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. thcy 220-224 methylenetetrahydrofolate reductase Homo sapiens 242-277 19211833-1 2009 We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. thcy 220-224 methylenetetrahydrofolate reductase Homo sapiens 279-284 19211833-9 2009 However, when creatinine was not in the model, the phosphatidylethanolamine N-methyltransferase 5465G-->A variant predicted lower tHcy (P < 0.001); an effect confined to the MTHFR 677TT genotype. thcy 133-137 methylenetetrahydrofolate reductase Homo sapiens 180-185 19211833-10 2009 Thus, in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma tHcy. thcy 135-139 methylenetetrahydrofolate reductase Homo sapiens 97-102 19125845-7 2009 RESULTS: Patients exhibited significantly higher tHcy and lower folate levels than controls; hyper-tHcy was significantly associated with the variables group (patients vs. controls), MTHFR genotype, and their interaction terms. thcy 99-103 methylenetetrahydrofolate reductase Homo sapiens 183-188 18823966-5 2008 RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG. thcy 18-22 methylenetetrahydrofolate reductase Homo sapiens 121-126 18823966-5 2008 RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG. thcy 18-22 methylenetetrahydrofolate reductase Homo sapiens 121-126 18823966-10 2008 CONCLUSIONS: Maternal tHcy was affected by MTHFR C677T, RFC1 A80G and GCPII C1561T polymorphisms. thcy 22-26 methylenetetrahydrofolate reductase Homo sapiens 43-48 18981340-9 2008 The tHcy was 0.19 mg/L higher among participants with the MTHFR C677T TT genotype compared with the CC genotype. thcy 4-8 methylenetetrahydrofolate reductase Homo sapiens 58-63 18981340-11 2008 CONCLUSIONS: The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%. thcy 68-72 methylenetetrahydrofolate reductase Homo sapiens 52-57 18981340-11 2008 CONCLUSIONS: The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%. thcy 127-131 methylenetetrahydrofolate reductase Homo sapiens 52-57 18981340-11 2008 CONCLUSIONS: The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%. thcy 127-131 methylenetetrahydrofolate reductase Homo sapiens 52-57 19996639-5 2008 We have also investigated the relationship between tHcy levels and the presence of MTHFR C677T gene polymorphism. thcy 51-55 methylenetetrahydrofolate reductase Homo sapiens 83-88 18790817-3 2008 To assess the effect on tHcy according to methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype. thcy 24-28 methylenetetrahydrofolate reductase Homo sapiens 42-77 18790817-3 2008 To assess the effect on tHcy according to methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype. thcy 24-28 methylenetetrahydrofolate reductase Homo sapiens 79-84 18855261-1 2008 UNLABELLED: The substitution of cytosine (C) by thymine (T) at nucleotide 677 of the methylenetetrahydrofolate reductase (MTHFR) gene, which converts an alanine to a valine residue, is a frequent polymorphism with reduced specific activity, associated with moderate increase in plasma homocysteine levels (tHcy) and risk of vascular diseases. thcy 306-310 methylenetetrahydrofolate reductase Homo sapiens 85-120 18855261-1 2008 UNLABELLED: The substitution of cytosine (C) by thymine (T) at nucleotide 677 of the methylenetetrahydrofolate reductase (MTHFR) gene, which converts an alanine to a valine residue, is a frequent polymorphism with reduced specific activity, associated with moderate increase in plasma homocysteine levels (tHcy) and risk of vascular diseases. thcy 306-310 methylenetetrahydrofolate reductase Homo sapiens 122-127 18189241-8 2008 High activity variants of COMT interact with the low activity variant of MTHFR to increase tHcy levels. thcy 91-95 methylenetetrahydrofolate reductase Homo sapiens 73-78 17522601-5 2008 RESULTS: Serum folate, MTHFR 677T allele and MTR 2756AA genotypes were the predictors of tHcy levels in pregnant women. thcy 89-93 methylenetetrahydrofolate reductase Homo sapiens 23-28 17522601-11 2008 CONCLUSIONS: Serum folate and MTHFR C677T and MTR A2576G gene polymorphisms were the determinants for tHcy levels. thcy 102-106 methylenetetrahydrofolate reductase Homo sapiens 30-35 18591889-10 2008 Our data show that menopause has a strong influence on tHcy concentration even in Type 2 diabetic women and demonstrate, for the first time, that it may modulate the association between tHcy and the common MTHFR polymorphism both in diabetic and non-diabetic women. thcy 55-59 methylenetetrahydrofolate reductase Homo sapiens 206-211 18591889-10 2008 Our data show that menopause has a strong influence on tHcy concentration even in Type 2 diabetic women and demonstrate, for the first time, that it may modulate the association between tHcy and the common MTHFR polymorphism both in diabetic and non-diabetic women. thcy 186-190 methylenetetrahydrofolate reductase Homo sapiens 206-211 18800176-6 2008 Plasma concentration of tHcy in CC and CT genotypes of MTHFR C677T was significantly increased in patients with OAD and in patients with DVT. thcy 24-28 methylenetetrahydrofolate reductase Homo sapiens 55-60 18800176-7 2008 Plasma concentration of tHcy in AC genotype of MTHFR A1298C was increased in patients with OAD and in patients with DVT. thcy 24-28 methylenetetrahydrofolate reductase Homo sapiens 47-52 18800176-11 2008 We conclude that MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with OAD and DVT. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 17-22 18800176-11 2008 We conclude that MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with OAD and DVT. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 33-38 18620331-10 2008 CONCLUSION: MTHFR TT and MS GG genotypes increase tHcy concentration and coronary stenosis risk, especially with low folatemia. thcy 50-54 methylenetetrahydrofolate reductase Homo sapiens 12-17 18774994-8 2008 The MTRR 66GG and MTHFR 1298 CC genotypes may confer protection against early nephropathy, possibly because they are associated with lower tHcy. thcy 139-143 methylenetetrahydrofolate reductase Homo sapiens 18-23 19326344-8 2008 Homocysteine (tHcy) was significantly negatively associated with serum folate, serum vitamin B12, and fruit and vegetable intake, and also depended on the MTHFR 677C>T genotype. thcy 14-18 methylenetetrahydrofolate reductase Homo sapiens 155-160 18412997-5 2008 The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy. thcy 42-46 methylenetetrahydrofolate reductase Homo sapiens 104-139 18412997-5 2008 The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy. thcy 42-46 methylenetetrahydrofolate reductase Homo sapiens 141-146 18412997-5 2008 The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy. thcy 171-175 methylenetetrahydrofolate reductase Homo sapiens 104-139 18412997-5 2008 The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy. thcy 171-175 methylenetetrahydrofolate reductase Homo sapiens 141-146 19996639-12 2008 CONCLUSIONS: Type 2 diabetics who are homozygous or heterozygous for the MTHFR C677T gene polymorphism showed normal tHcy levels. thcy 117-121 methylenetetrahydrofolate reductase Homo sapiens 73-78 17618615-3 2007 OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications. thcy 49-53 methylenetetrahydrofolate reductase Homo sapiens 65-100 17561949-1 2007 The influence of antiepileptic drugs (AEDs) and/or common polymorphisms (677C --> T, 1298A --> C) of the methylene-tetrahydrofolate-reductase (MTHFR) gene on the recurrence time of hyper-total-homocysteinemia (tHcy > 13 micromol/L) was investigated in 59 hyper-homocysteinemic patients (34M/25F, 20-49 years). thcy 216-220 methylenetetrahydrofolate reductase Homo sapiens 111-147 17561949-3 2007 Four MTHFR polymorphism groups were identified with the following tHcy (micromol/L) and folate (nmol/L) levels (mean +/- SD): (a) MTHFR677TT/1298AA, 24 patients, 36.0 +/- 4.8, 4.1 +/- 0.7; (b) MTHFR677CT/1298AC 27.1 +/- 2.7, 5.3 +/- 1.0 (n = 15); (c) MTHFR677CT/1298AA 16.6 +/- 3.6, 6.8 +/- 1.0 (n = 11), all taking enzyme-inducing AEDs; and (d) MTHFR677TT/1298AA 24.5 +/- 3.2, 5.6 +/- 1.1 (n = 9), treated with new AEDs. thcy 66-70 methylenetetrahydrofolate reductase Homo sapiens 5-10 17822659-13 2007 Our finding supports an important role of the MTHFR gene in CAD and provides evidence of polygenic regulation of tHcy. thcy 113-117 methylenetetrahydrofolate reductase Homo sapiens 46-51 17618615-3 2007 OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications. thcy 49-53 methylenetetrahydrofolate reductase Homo sapiens 102-107 17618615-6 2007 Homozygosity for the T allele of MTHFR was more frequent in diabetics than in healthy subjects (12.8% vs. 7.2%) and it was associated with higher tHcy levels. thcy 146-150 methylenetetrahydrofolate reductase Homo sapiens 33-38 17436311-7 2007 We confirmed the strong associations of MTHFR c.665C>T with tHcy and folate, but also observed significant (P<0.01) changes in metabolite concentrations according to other gene polymorphisms. thcy 63-67 methylenetetrahydrofolate reductase Homo sapiens 40-45 16908053-8 2007 A suppression effect may explain the non-significant total MTHFR-IHD relation (OR=1.275, 95% CI: 1.02 to 1.71 for the indirect MTHFR-tHcy-IHD path; OR=0.52, 95% CI: 0.17 to 1.64 for the direct MTHFR-IHD path). thcy 133-137 methylenetetrahydrofolate reductase Homo sapiens 127-132 17436239-5 2007 The MTHFR 677C-->T polymorphism, folate, riboflavin, cobalamin, and vitamin B6 were independent predictors of tHcy in multivariate models (P<.001), and genotype effects were strongest when B vitamins were low (P<or=.006). thcy 113-117 methylenetetrahydrofolate reductase Homo sapiens 4-9 17436239-6 2007 Conversely, the MTHFR polymorphism influenced B vitamin effects, which were strongest in the TT group, in which the estimated tHcy difference between subjects with vitamin concentrations in the lowest compared with the highest quartile was 5.4 micromol/liter for folate, 4.1 micromol/liter for riboflavin, 3.2 micromol/liter for cobalamin, and 2.1 micromol/liter for vitamin B6. thcy 126-130 methylenetetrahydrofolate reductase Homo sapiens 16-21 17461517-9 2007 CONCLUSION: The results of the present study demonstrate that the MTR 2756A > G and MTHFR 677C > T polymorphisms interact with elevated total homocysteine (tHcy) levels, leading to an increased risk of ischemic stroke. thcy 162-166 methylenetetrahydrofolate reductase Homo sapiens 87-92 17334642-3 2007 The MTHFR 677C>T polymorphism was associated with increased tHcy concentrations in both the children and the adolescents (P<0.001 for both age groups) in both genders. thcy 63-67 methylenetetrahydrofolate reductase Homo sapiens 4-9 17334642-4 2007 The effect of MTHFR 1298A>C was studied separately in subjects with the 677CC and 677CT genotypes, and the 1298C allele was found to be associated with higher tHcy levels both when children were stratified according to 677C>T genotypes, and when using haplotype analyses and diplotype reconstructions. thcy 162-166 methylenetetrahydrofolate reductase Homo sapiens 14-19 17334642-8 2007 The major genetic impact on tHcy concentrations is attributable to the MTHFR 677C>T polymorphism. thcy 28-32 methylenetetrahydrofolate reductase Homo sapiens 71-76 17342693-2 2007 The aims of the present study were to explore the effect of alternate vitamin supplementation with folic acid or vitamin B 12 on tHcy concentrations in haemodialysis (HD) patients, and to compare changes in tHcy concentrations with MTHFR genotype. thcy 207-211 methylenetetrahydrofolate reductase Homo sapiens 232-237 17497026-15 2007 Our data suggest that HHcy is strongly and independently associated to CAD risk increase; and MTHFR C677T polymorphism and smoking habits were the main predictors of tHcy levels. thcy 166-170 methylenetetrahydrofolate reductase Homo sapiens 94-99 16908053-8 2007 A suppression effect may explain the non-significant total MTHFR-IHD relation (OR=1.275, 95% CI: 1.02 to 1.71 for the indirect MTHFR-tHcy-IHD path; OR=0.52, 95% CI: 0.17 to 1.64 for the direct MTHFR-IHD path). thcy 133-137 methylenetetrahydrofolate reductase Homo sapiens 127-132 17065574-4 2006 THcy was higher but within normal ranges in MTHFR 677TT homozygotes (10.6%) and carriers of the MTHFR 1793A allele (8%). thcy 0-4 methylenetetrahydrofolate reductase Homo sapiens 44-49 17111197-10 2006 Patients with MTHFR C677T and MTHFR A1298C gene mutations had a similar mean tHcy levels with controls. thcy 77-81 methylenetetrahydrofolate reductase Homo sapiens 14-19 17111197-10 2006 Patients with MTHFR C677T and MTHFR A1298C gene mutations had a similar mean tHcy levels with controls. thcy 77-81 methylenetetrahydrofolate reductase Homo sapiens 30-35 17065574-4 2006 THcy was higher but within normal ranges in MTHFR 677TT homozygotes (10.6%) and carriers of the MTHFR 1793A allele (8%). thcy 0-4 methylenetetrahydrofolate reductase Homo sapiens 96-101 16533539-5 2006 However, DS patients with the MTHFR TT genotype showed an increased of plasma homocysteine (tHcy). thcy 92-96 methylenetetrahydrofolate reductase Homo sapiens 30-35 16702348-5 2006 Increasing age, male sex, smoking, coffee consumption, high blood pressure, unfavorable lipid profile, high creatinine, and the MTHFR 677C > T polymorphism are among the factors associated with increased tHcy levels; physical activity, moderate alcohol consumption, and a good folate or vitamin B-12 status are associated with lower tHcy levels. thcy 207-211 methylenetetrahydrofolate reductase Homo sapiens 128-133 16968465-7 2006 Folate and vitamin B12 concentrations, estimated glomerular filtration rate (GFR), MTHFR 677C > T polymorphism were the major determinants of tHcy in this population. thcy 145-149 methylenetetrahydrofolate reductase Homo sapiens 83-88 16524711-5 2006 Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR 677 TT genotype relative to the CC genotype. thcy 83-87 methylenetetrahydrofolate reductase Homo sapiens 126-131 16706975-3 2006 Extensive candidate gene studies have identified several genetic variants, including the MTHFR 677C>T, that influence tHcy levels, but so far only part of the genetic variation in tHcy can be explained. thcy 121-125 methylenetetrahydrofolate reductase Homo sapiens 89-94 16681562-16 2006 Genotypic characteristics suggest that C(677)T MTHFR mutation confers a higher risk for stroke to both homozygous and heterozygous T allele carriers that cannot be ascribed solely to raised tHcy and/or lower folate status in CT subjects, nor to phenotypic expression of conventional risk factors for stroke. thcy 190-194 methylenetetrahydrofolate reductase Homo sapiens 47-52 16704755-11 2006 Patients with the MTHFR TT genotype had higher plasma tHcy, serum creatinine, cholesterol and triglyceride concentrations than patients with the MTHFR CC genotype. thcy 54-58 methylenetetrahydrofolate reductase Homo sapiens 18-23 16340945-2 2006 OBJECTIVE: To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype. thcy 137-141 methylenetetrahydrofolate reductase Homo sapiens 157-162 16340945-8 2006 However, the MTHFR TT genotype was associated with a significant decrease in tHcy compared with the CC/CT genotype in which an increase was observed. thcy 77-81 methylenetetrahydrofolate reductase Homo sapiens 13-18 16522921-5 2006 RESULTS: Subjects with the MTHFR 677TT genotype had higher serum tHcy concentrations than did those with the MTHFR 677CC genotype (P < 0.001), and this effect was greater in subjects with low serum folate status (P for interaction = 0.026). thcy 65-69 methylenetetrahydrofolate reductase Homo sapiens 27-32 16522921-8 2006 An interaction (P = 0.05) was observed between the MTHFR 677TT and RFC1 80GG genotypes, whereby persons with this genotype combination had a mean (+/-SEM) serum tHcy concentration (18.5 +/- 1.2 micromol/L) that was 5.1 micromol/L greater than the mean value of 13.4 +/- 0.2 micromol/L for the whole population. thcy 161-165 methylenetetrahydrofolate reductase Homo sapiens 51-56 16522921-10 2006 An interaction between the MTHFR 677TT and RFC1 80GG genotypes was observed whereby persons with this combination had higher serum tHcy. thcy 131-135 methylenetetrahydrofolate reductase Homo sapiens 27-32 16234842-1 2006 OBJECTIVE: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. thcy 205-209 methylenetetrahydrofolate reductase Homo sapiens 111-146 16234842-1 2006 OBJECTIVE: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. thcy 205-209 methylenetetrahydrofolate reductase Homo sapiens 148-153 16234842-12 2006 CONCLUSIONS: Under conditions of lower folate status (as estimated by either plasma concentration or reported dietary consumption), gender modifies the association of the MTHFR(C677T) polymorphism with tHcy concentrations in healthy children. thcy 202-206 methylenetetrahydrofolate reductase Homo sapiens 171-176 15883436-1 2005 BACKGROUND: Vitamin status, methylenentetrahydrofolate reductase (MTHFR) genotype, age, sex, and lifestyle factors are all predictors of total homocysteine (tHcy) concentrations in adults. thcy 157-161 methylenetetrahydrofolate reductase Homo sapiens 66-71 16397167-10 2006 MTHFR C677T genotype was an independent determinant of tHcy levels at baseline (P=0.005), but A1298C was not (P=0.08). thcy 55-59 methylenetetrahydrofolate reductase Homo sapiens 0-5 16397167-14 2006 MTHFR C677T but not A1298C is independently associated with tHcy levels at baseline, and neither impacts the tHcy-lowering effect of vitamins used in this study. thcy 60-64 methylenetetrahydrofolate reductase Homo sapiens 0-5 16076517-4 2005 Homozygosity for MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (P<0.01), which was mainly driven by the male group. thcy 56-60 methylenetetrahydrofolate reductase Homo sapiens 17-22 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. thcy 257-261 methylenetetrahydrofolate reductase Homo sapiens 85-120 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. thcy 257-261 methylenetetrahydrofolate reductase Homo sapiens 122-127 16002814-10 2005 CONCLUSIONS: Moderate alcohol intake and low MTHFR activity have adverse effects on tHcy, but those effects may be overcome by sufficient folate intake. thcy 84-88 methylenetetrahydrofolate reductase Homo sapiens 45-50 16303969-1 2005 PURPOSE: The aim of this case-control study was to investigate the relationship between homocysteine (tHcy), 5,10 methylene tetrahydrofolate reductase (MTHFR) C677T genotype, folate and vitamin B12 status, and retinal vein occlusion (RVO). thcy 102-106 methylenetetrahydrofolate reductase Homo sapiens 152-157 16316363-2 2005 The methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, an important determinant of plasma tHcy concentrations, could therefore constitute an important prognostic marker. thcy 107-111 methylenetetrahydrofolate reductase Homo sapiens 4-39 16316363-2 2005 The methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, an important determinant of plasma tHcy concentrations, could therefore constitute an important prognostic marker. thcy 107-111 methylenetetrahydrofolate reductase Homo sapiens 41-46 16259797-2 2005 MTHFR C(677)T increases tHcy in association with low folate. thcy 24-28 methylenetetrahydrofolate reductase Homo sapiens 0-5 16190942-7 2005 In contrast, polymorphisms in the methylene tetrahydrofolate reductase gene (MTHFR 677 C-->T, 1298 A-->C, 1793 G-->A) had no significant impact on tHcy. thcy 156-160 methylenetetrahydrofolate reductase Homo sapiens 77-82 15883436-14 2005 The MTHFR 677C-->T polymorphism played a minor role in determining tHcy concentrations in children. thcy 70-74 methylenetetrahydrofolate reductase Homo sapiens 4-9 15871860-4 2005 The C677T MTHFR gene polymorphism was determined by analysis of HinfI restriction fragment length polymorphism tHcy levels were significantly lower in diabetic patients compared with control subjects (7.7 +/- 2.2 vs. 11.8 +/- 4.5 micromol/l, P < 0.0001). thcy 111-115 methylenetetrahydrofolate reductase Homo sapiens 10-15 15785306-1 2005 BACKGROUND: Variation of plasma total homocysteine (tHcy) levels among individuals is modified by 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and selected atherosclerotic risk factors. thcy 52-56 methylenetetrahydrofolate reductase Homo sapiens 98-138 15785306-1 2005 BACKGROUND: Variation of plasma total homocysteine (tHcy) levels among individuals is modified by 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and selected atherosclerotic risk factors. thcy 52-56 methylenetetrahydrofolate reductase Homo sapiens 140-145 15871860-8 2005 On multiple regression, tHcy levels were associated with sex (P < 0.03) and glucose levels (P < 0.04) in diabetic patients, and with uric acid (P < 0.002) and MTHFR genotype (P < 0.03) in control subjects. thcy 24-28 methylenetetrahydrofolate reductase Homo sapiens 168-173 15735067-8 2005 An interaction between the MTHFR genotype and plasma folate on tHcy was detected (P = 0.047). thcy 63-67 methylenetetrahydrofolate reductase Homo sapiens 27-32 15735067-11 2005 The results also show that, similar to adults, plasma folate concentration is important in determining the contribution of the MTHFR C677T mutation to tHcy concentrations in children. thcy 151-155 methylenetetrahydrofolate reductase Homo sapiens 127-132 15466944-9 2004 Increased plasma THCy level was found in 10 children and adolescents from 12 cases homozygous for the C677T polymorphism of the MTHFR gene. thcy 17-21 methylenetetrahydrofolate reductase Homo sapiens 128-133 15585767-11 2004 The difference in tHcy according to MTHFR genotype was not significant. thcy 18-22 methylenetetrahydrofolate reductase Homo sapiens 36-41 15447919-1 2004 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy). thcy 220-224 methylenetetrahydrofolate reductase Homo sapiens 21-56 15447919-1 2004 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy). thcy 220-224 methylenetetrahydrofolate reductase Homo sapiens 63-68 15447919-3 2004 OBJECTIVE: The aim of the study was to investigate the phenotypic expression of the MTHFR 677C-->T polymorphism in terms of plasma tHcy concentrations in patients with thyroid dysfunction. thcy 134-138 methylenetetrahydrofolate reductase Homo sapiens 84-89 15151507-2 2004 While the thermolabile polymorphism in MTHFR encoding methylenetetrahydrofolate reductase is the best-studied genetic factor associated with variation in plasma tHCy, other candidate genes are being evaluated. thcy 161-165 methylenetetrahydrofolate reductase Homo sapiens 39-44 15136061-5 2004 The MTHFR 677TT genotype was significantly associated with elevated tHcy concentrations in smokers (P = 0.001) but not in non-smokers (P = 0.36). thcy 68-72 methylenetetrahydrofolate reductase Homo sapiens 4-9 15136061-6 2004 Among smokers, the MTHFR 677TT genotype was significantly associated with high tHcy in heavy smokers (P = 0.003) but not light smokers (P = 0.09), in men (P = 0.003) but not women (P = 0.11), and in subjects from the lowest serum folate quartile (P = 0.49) but not from folate quartiles 2-4 (P = 0.49). thcy 79-83 methylenetetrahydrofolate reductase Homo sapiens 19-24 15151507-2 2004 While the thermolabile polymorphism in MTHFR encoding methylenetetrahydrofolate reductase is the best-studied genetic factor associated with variation in plasma tHCy, other candidate genes are being evaluated. thcy 161-165 methylenetetrahydrofolate reductase Homo sapiens 54-89 15044114-3 2004 The tHcy value was significantly lower (p < 0.001) in young women with CC or CT of MTHFR than with TT (10.9+/-4.7 micromol/L) (n =250). thcy 4-8 methylenetetrahydrofolate reductase Homo sapiens 86-91 12911562-9 2003 Independent predictors of ln-tHcy included creatinine, red blood cell folate, and the MTHFR 677TT genotype. thcy 29-33 methylenetetrahydrofolate reductase Homo sapiens 86-91 15040829-4 2004 Individuals homozygous (TT) for the MTHFR C677T polymorphism who have low plasma folate concentrations exhibit elevated plasma homocysteine (tHcy) concentrations that may compromise bone quality. thcy 141-145 methylenetetrahydrofolate reductase Homo sapiens 36-41 15002923-2 2004 C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). thcy 130-134 methylenetetrahydrofolate reductase Homo sapiens 22-27 14758571-9 2004 A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase. thcy 36-40 methylenetetrahydrofolate reductase Homo sapiens 193-198 14758571-9 2004 A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase. thcy 259-263 methylenetetrahydrofolate reductase Homo sapiens 193-198 12930236-11 2003 CONCLUSIONS: The findings suggest that in D2p tHcy decreases even with modest improvement of glycaemic control; moreover patients homozygous for the MTHFR C677T mutation show the largest changes in tHcy levels with concomitant changing of HbA1c. thcy 198-202 methylenetetrahydrofolate reductase Homo sapiens 149-154 15073633-1 2004 The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease. thcy 146-150 methylenetetrahydrofolate reductase Homo sapiens 30-65 15073633-1 2004 The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease. thcy 146-150 methylenetetrahydrofolate reductase Homo sapiens 72-77 15019536-7 2004 Subjects homozygous for the rare MTHFR T allele had 34% higher median tHcy concentrations than CC homozygotes or CT heterozygotes, but responses to gemfibrozil did not differ significantly among genotypes. thcy 70-74 methylenetetrahydrofolate reductase Homo sapiens 33-38 14742985-7 2004 RESULTS: Plasma PAI-1 Ag levels were the highest in patients with the 4G/4G genotype, and plasma tHcy levels were the highest in patients with TT genotypes of MTHFR C677T. thcy 97-101 methylenetetrahydrofolate reductase Homo sapiens 159-164 14608052-2 2003 However, little is known about the influence of subject characteristics, such as age and sex, on the relation between the C677T MTHFR polymorphism and fasting plasma total homocysteine (tHcy) concentrations. thcy 186-190 methylenetetrahydrofolate reductase Homo sapiens 128-133 14608052-10 2003 Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations. thcy 100-104 methylenetetrahydrofolate reductase Homo sapiens 68-73 12930236-10 2003 A multivariate analysis revealed MTHFR polymorphism and HbA1c as strong determinants of changes in tHcy with time. thcy 99-103 methylenetetrahydrofolate reductase Homo sapiens 33-38 12930236-11 2003 CONCLUSIONS: The findings suggest that in D2p tHcy decreases even with modest improvement of glycaemic control; moreover patients homozygous for the MTHFR C677T mutation show the largest changes in tHcy levels with concomitant changing of HbA1c. thcy 46-50 methylenetetrahydrofolate reductase Homo sapiens 149-154 12707400-6 2003 A linear multivariate regression analysis showed that red blood cell folate (P < 0.001), creatinine (P < 0.001), and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677T allele (P = 0.013) are independent predictors of tHcy plasma level explaining 49% of the variance of tHcy plasma concentration. thcy 230-234 methylenetetrahydrofolate reductase Homo sapiens 127-167 12797595-1 2003 The C677T transition of methylenetetrahydrofolate reductase (MTHFR) gene causes a moderate increase in total plasma homocysteine (tHcy). thcy 130-134 methylenetetrahydrofolate reductase Homo sapiens 24-59 12797595-1 2003 The C677T transition of methylenetetrahydrofolate reductase (MTHFR) gene causes a moderate increase in total plasma homocysteine (tHcy). thcy 130-134 methylenetetrahydrofolate reductase Homo sapiens 61-66 14650352-7 2003 PA had a small but significant lowering effect on plasma tHcy adjusted for folate levels in subjects with the 677TT genotype of the MTHFR gene. thcy 57-61 methylenetetrahydrofolate reductase Homo sapiens 132-137 12687650-3 2003 Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population. thcy 142-146 methylenetetrahydrofolate reductase Homo sapiens 46-81 12687650-3 2003 Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population. thcy 142-146 methylenetetrahydrofolate reductase Homo sapiens 83-88 12687650-3 2003 Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population. thcy 205-209 methylenetetrahydrofolate reductase Homo sapiens 46-81 12687650-3 2003 Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population. thcy 205-209 methylenetetrahydrofolate reductase Homo sapiens 83-88 12687650-4 2003 We investigated the simultaneous effect of sex, age, and MTHFR(C677T) genotype on the distribution of tHcy in a cross-sectional study design. thcy 102-106 methylenetetrahydrofolate reductase Homo sapiens 57-62 12687650-13 2003 The MTHFR(C677T) polymorphism explained 6% of the phenotypic variation in tHcy. thcy 74-78 methylenetetrahydrofolate reductase Homo sapiens 4-9 12687650-14 2003 In conclusion, we found that tHcy is associated with sex, age, and MTHFR genotype. thcy 29-33 methylenetetrahydrofolate reductase Homo sapiens 67-72 12707400-6 2003 A linear multivariate regression analysis showed that red blood cell folate (P < 0.001), creatinine (P < 0.001), and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677T allele (P = 0.013) are independent predictors of tHcy plasma level explaining 49% of the variance of tHcy plasma concentration. thcy 282-286 methylenetetrahydrofolate reductase Homo sapiens 127-167 12644913-2 2003 The combined effects of renal failure, folate and vitamin B(12) levels, and a common mutation (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene that leads to total plasma homocysteine (tHcy) elevation in CRF children were investigated. thcy 199-203 methylenetetrahydrofolate reductase Homo sapiens 109-144 12801809-8 2003 Third, the C667T transition of the methylenetetrahydrofolate reductase causes a moderate increase in tHcy but no or only minor increased CVD risk. thcy 101-105 methylenetetrahydrofolate reductase Homo sapiens 35-70 12694331-4 2003 The most consistent effect on tHcy plasma concentrations is observed for 677C>T of MTHFR, whereas GCP2, RFC1, and TCN2 polymorphisms show no major effect on tHcy concentrations. thcy 30-34 methylenetetrahydrofolate reductase Homo sapiens 86-91 12642343-3 2003 Serum folate, red cell folate, vitamin B(12), and tHcy concentrations were significantly influenced by MTHFR 677C>T genotypes. thcy 50-54 methylenetetrahydrofolate reductase Homo sapiens 103-108 12642343-4 2003 A particularly strong interaction was observed between the MTHFR 677TT genotype and serum folate, which led to a high tHcy phenotype that was more pronounced in males. thcy 118-122 methylenetetrahydrofolate reductase Homo sapiens 59-64 12651974-3 2003 A common 677C-->T mutation in the MTHFR gene results in decreased enzymic activity, and contributes to increased plasma tHcy, in association with low plasma folate. thcy 123-127 methylenetetrahydrofolate reductase Homo sapiens 37-42 12651974-4 2003 A recently described 1298A-->C mutation in the MTHFR gene clearly reduces MTHFR activity (although to a lesser extent than the 677C-->T) but its effect on plasma tHcy levels is not yet clear. thcy 168-172 methylenetetrahydrofolate reductase Homo sapiens 50-55 12651974-15 2003 Both MTHFR mutations showed effects on plasma tHcy levels. thcy 46-50 methylenetetrahydrofolate reductase Homo sapiens 5-10 12644913-2 2003 The combined effects of renal failure, folate and vitamin B(12) levels, and a common mutation (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene that leads to total plasma homocysteine (tHcy) elevation in CRF children were investigated. thcy 199-203 methylenetetrahydrofolate reductase Homo sapiens 146-151 12548301-8 2003 Homozygote frequency for MTHFR genotype TT was 5.0% and their plasma tHcy was 14.8 micro mol/l compared to the mean of the other subjects, 10.5 micro mol/l, P<0.05. thcy 69-73 methylenetetrahydrofolate reductase Homo sapiens 25-30 12601627-11 2003 Further supplementation with 1 mg vitamin B(12) resulted in greater tHcy reduction among subjects with the MTHFR 677 T/T genotype (P<.01, T/T v C/C or C/T) while lowering MMA equally in all MTHFR genotypes. thcy 68-72 methylenetetrahydrofolate reductase Homo sapiens 107-112 12560354-3 2003 Individuals with the MTHFR 677C-->T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 21-26 12560354-10 2003 CONCLUSIONS: Folate and riboflavin interact to lower plasma tHcy, possibly by maximizing the catalytic activity of MTHFR. thcy 60-64 methylenetetrahydrofolate reductase Homo sapiens 115-120 24122328-13 2003 No correlation was found between tHcy concentration and the number of vascular access thrombotic events; homozygotes for MTHFR had higher tHcy but no more vascular access thrombotic events. thcy 138-142 methylenetetrahydrofolate reductase Homo sapiens 121-126 12187113-6 2002 We observed a significant relationship between MTHFR genotypes and total plasma homocysteine (tHcy), as well as folate concentration. thcy 94-98 methylenetetrahydrofolate reductase Homo sapiens 47-52 14698652-4 2003 tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution. thcy 75-79 methylenetetrahydrofolate reductase Homo sapiens 114-119 14698652-5 2003 Elevated tHcy levels (p < 0.05) were identified in smokers and coffee drinkers, with the degree of elevation dependent on MTHFR C677T genotype. thcy 9-13 methylenetetrahydrofolate reductase Homo sapiens 125-130 12325051-9 2002 The distribution of the two common polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) was similar in patients with elevated and normal plasma tHcy. thcy 172-176 methylenetetrahydrofolate reductase Homo sapiens 56-91 14698652-4 2003 tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution. thcy 0-4 methylenetetrahydrofolate reductase Homo sapiens 31-36 12145019-2 2002 A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy). thcy 201-205 methylenetetrahydrofolate reductase Homo sapiens 15-20 12145019-10 2002 CONCLUSIONS: The high tHcy concentration typically associated with homozygosity for the 677C-->T variant of MTHFR occurs only with poor riboflavin status. thcy 22-26 methylenetetrahydrofolate reductase Homo sapiens 111-116 12042673-2 2002 In this study, we investigated whether a second common polymorphism of the gene, MTHFR 1298A>C, is an independent risk factor for colorectal cancer and if it is associated with plasma folate and total homocysteine (tHcy) levels. thcy 218-222 methylenetetrahydrofolate reductase Homo sapiens 81-86 12421498-1 2002 OBJECTIVE: To study the influence of mutation of 677 C to T in the methylenetetrahydrofolate reductase (MTHFR) gene on the plasma total homocysteine (tHcy) levels in hemodialysis patients. thcy 150-154 methylenetetrahydrofolate reductase Homo sapiens 67-102 12421498-1 2002 OBJECTIVE: To study the influence of mutation of 677 C to T in the methylenetetrahydrofolate reductase (MTHFR) gene on the plasma total homocysteine (tHcy) levels in hemodialysis patients. thcy 150-154 methylenetetrahydrofolate reductase Homo sapiens 104-109 11943942-5 2002 Subjects with the MTHFR 677TT genotype showed higher levels of tHcy compared with the 677CC genotype in patients (P = 0.010) and in controls (P = 0.030). thcy 63-67 methylenetetrahydrofolate reductase Homo sapiens 18-23 11961021-8 2002 Independent predictors of tHcy plasma levels were serum albumin, alpha-EGR, red blood cell folate, and certain MTHFR genotypes. thcy 26-30 methylenetetrahydrofolate reductase Homo sapiens 111-116 11961021-9 2002 A logistic regression analysis showed that the MTHFR genotype is a predictor for having a tHcy plasma concentration within the fourth quartile. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 47-52 11943942-7 2002 Although tHcy levels are significantly higher in those homozygous for the MTHFR C677T mutation, this genotype does not increase the thrombotic risk in our study population. thcy 9-13 methylenetetrahydrofolate reductase Homo sapiens 74-79 11273876-6 2001 Normalization of tHcy plasma levels was dependent on a lower baseline tHcy level (P: = 0.01976), younger age (P: = 0.00896), and MTHFR 677TT/1298AA or 677CT/1298AC genotypes (P: = 0.00208 and P: = 0.02320, respectively). thcy 17-21 methylenetetrahydrofolate reductase Homo sapiens 129-134 12033523-3 2002 A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and selected life-style related factors. thcy 158-162 methylenetetrahydrofolate reductase Homo sapiens 182-222 12033523-3 2002 A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and selected life-style related factors. thcy 158-162 methylenetetrahydrofolate reductase Homo sapiens 224-229 12033523-8 2002 A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy. thcy 143-147 methylenetetrahydrofolate reductase Homo sapiens 86-91 12033523-9 2002 The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype. thcy 40-44 methylenetetrahydrofolate reductase Homo sapiens 104-109 11872884-6 2002 Cases with tHcy concentration above the cutoff level of 12 micromol/L were significantly more represented in the group of patients with sCAD compared with control subjects (64% versus 13.9%; 95% CI, 2.25 to 44.23; P=0.003); a significant association between the MTHFR TT genotype and sCAD was also observed (36% versus 11.1%; 95% CI, 1.10 to 19.23; P=0.045). thcy 11-15 methylenetetrahydrofolate reductase Homo sapiens 262-267 11431185-4 2001 Multiple stepwise regression analysis showed that the MTHFR 677C-->T/1298A-->C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B(12) plasma level were significant predictors of tHcy plasma levels. thcy 225-229 methylenetetrahydrofolate reductase Homo sapiens 54-59 11431185-5 2001 Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes. thcy 67-71 methylenetetrahydrofolate reductase Homo sapiens 48-53 11431185-5 2001 Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes. thcy 114-118 methylenetetrahydrofolate reductase Homo sapiens 48-53 11431185-8 2001 This study shows that the MTHFR 677TT/1298AA genotype, but not the 677CT/1298AC genotype, is a significant predictor of tHcy plasma levels in dialysis patients. thcy 120-124 methylenetetrahydrofolate reductase Homo sapiens 26-31 11956665-9 2002 The sufficiently high dose of folate seems to be able to decrease plasma tHcy in all three individual MTHFR polymorphism groups, to almost the same post-treatment concentrations. thcy 73-77 methylenetetrahydrofolate reductase Homo sapiens 102-107 11815318-2 2002 The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH(2)) (MTHFR) influences the tHcy concentration and the response to tHcy-lowering therapy. thcy 112-116 methylenetetrahydrofolate reductase Homo sapiens 90-95 11815318-2 2002 The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH(2)) (MTHFR) influences the tHcy concentration and the response to tHcy-lowering therapy. thcy 151-155 methylenetetrahydrofolate reductase Homo sapiens 90-95 11815318-7 2002 RESULTS: Changes in plasma tHcy concentration depended on the supplemented folate derivative and the MTHFR genotype. thcy 27-31 methylenetetrahydrofolate reductase Homo sapiens 101-106 11815318-12 2002 CONCLUSIONS: The response to tHcy-lowering therapy is influenced by MTHFR genotype. thcy 29-33 methylenetetrahydrofolate reductase Homo sapiens 68-73 11684547-5 2001 Conversely, combined MTR and MTHFR genotypes (MTR 2756AG and 2756GG and MTHFR 677TT/1298AA and 677CT/1298AC) were found more often in the highest (n = 34) compared with the lowest plasma tHcy decile (n = 19; P = 0.0252; OR, 1.983; 95% CI, 1.079 to 3.643). thcy 187-191 methylenetetrahydrofolate reductase Homo sapiens 29-34 11684547-7 2001 In summary, our study shows that the 2756A-->G transition of MTR in combination with MTHFR 677TT/1298AA and 677CT/1298AC can be associated with extremely high tHcy plasma levels. thcy 162-166 methylenetetrahydrofolate reductase Homo sapiens 88-93 11592445-8 2001 The MTHFR 677TT genotype was less frequent and was associated with a significantly higher tHcy level in patients. thcy 90-94 methylenetetrahydrofolate reductase Homo sapiens 4-9 11398138-16 2001 The following contributions to the variation of tHcy were seen in a multivariate regression model: plasma cobalamin (11%), creatinine (11%), plasma folate (8%), fat-free mass (5%), estradiol (2%), MTHFR polymorphisms (2%), and plasma protein (1%). thcy 48-52 methylenetetrahydrofolate reductase Homo sapiens 197-202 11133719-2 2001 A thermolabile form of a pivotal enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase (MTHFR), has been associated with vascular occlusive disease and raised tHcy levels. thcy 176-180 methylenetetrahydrofolate reductase Homo sapiens 68-103 11330536-9 2001 The prevalence of the MTHFR 677TT genotype in renal transplant recipients was not significantly higher in patients than in controls (mutant allele frequency: 0.48 in patients and 0.47 in controls) and was associated with significantly higher fasting and postmethionine tHcy levels both in controls and patients. thcy 269-273 methylenetetrahydrofolate reductase Homo sapiens 22-27 11330536-11 2001 Patients with the MTHFR 677TT genotype had the major percentage of decrease of tHcy levels with respect to the other genotypes. thcy 79-83 methylenetetrahydrofolate reductase Homo sapiens 18-23 11169021-1 2001 BACKGROUND: The total homocysteine (tHcy) plasma level, which is partly determined by the MTHFR 677C-->T genotype, may be associated with vascular disease. thcy 36-40 methylenetetrahydrofolate reductase Homo sapiens 90-95 11133719-2 2001 A thermolabile form of a pivotal enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase (MTHFR), has been associated with vascular occlusive disease and raised tHcy levels. thcy 176-180 methylenetetrahydrofolate reductase Homo sapiens 105-110 11054348-2 2000 Considering that Cys is mainly synthesized from Hcy, a common C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene may affect the serum total Cys (tCys) concentration, as well as total Hcy (tHcy) concentration, through reduced remethylation of Hcy to methionine, even in hemodialysis patients. thcy 208-212 methylenetetrahydrofolate reductase Homo sapiens 84-119 11177206-2 2000 The aim of the present study was to determine the impact of this MTHFR common mutation on plasma and erythrocyte folate (RCF) and plasma total homocysteine (tHcy) concentrations in healthy French adults. thcy 157-161 methylenetetrahydrofolate reductase Homo sapiens 65-70 11054348-2 2000 Considering that Cys is mainly synthesized from Hcy, a common C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene may affect the serum total Cys (tCys) concentration, as well as total Hcy (tHcy) concentration, through reduced remethylation of Hcy to methionine, even in hemodialysis patients. thcy 208-212 methylenetetrahydrofolate reductase Homo sapiens 121-126 11054348-5 2000 Slopes of regression lines relating tHcy and tCys concentrations differed between the MTHFR genotypes, and the relationship was strengthened with a decreasing number of T alleles. thcy 36-40 methylenetetrahydrofolate reductase Homo sapiens 86-91 11092508-1 2000 Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. thcy 179-183 methylenetetrahydrofolate reductase Homo sapiens 39-74 11092508-1 2000 Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. thcy 179-183 methylenetetrahydrofolate reductase Homo sapiens 76-81 11092508-8 2000 These data suggest that older women who are homozygous for the MTHFR 677C --> T mutation may be at risk for greater elevations in plasma tHcy in response to moderately low folate intake as compared with individuals with the normal or heterozygous genotypes. thcy 140-144 methylenetetrahydrofolate reductase Homo sapiens 63-68 11004224-9 2000 In a prespecified subgroup analysis (n = 496), the MTHFR genotype also influenced tHcy levels and compound heterozygous patients had significantly lower folate levels as compared with MTHFR 677CC/1298AA and 677CC/1298CC. thcy 82-86 methylenetetrahydrofolate reductase Homo sapiens 51-56 11004224-5 2000 MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P < 0. thcy 73-77 methylenetetrahydrofolate reductase Homo sapiens 0-5 11004224-5 2000 MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P < 0. thcy 73-77 methylenetetrahydrofolate reductase Homo sapiens 109-114 11004224-5 2000 MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P < 0. thcy 86-90 methylenetetrahydrofolate reductase Homo sapiens 0-5 11004224-5 2000 MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P < 0. thcy 86-90 methylenetetrahydrofolate reductase Homo sapiens 109-114 11004224-10 2000 This study shows that the MTHFR 677TT/1298AA and 677CT/1298AC genotypes are significant predictors of tHcy and folate plasma levels. thcy 102-106 methylenetetrahydrofolate reductase Homo sapiens 26-31 11057853-6 2000 When adjusted for determinants of hyperhomocysteinemia in the patient and the control populations (generalized linear model), fasting tHcy levels were significantly higher in subjects with association of the two gene abnormalities (24.2+/-3.8 micromol/L) than in subjects with the MTHFR 677TT mutation only (14.0+/-5.8 micromol/L, p = 0.004). thcy 134-138 methylenetetrahydrofolate reductase Homo sapiens 281-286 10926884-9 2000 The riboflavin-tHcy relationship was modified by genotype (P = 0.004) and was essentially confined to subjects with the C677T transition of the MTHFR gene. thcy 15-19 methylenetetrahydrofolate reductase Homo sapiens 144-149 10982535-12 2000 Homozygosity for the MTHFR variant was weakly predictive of tHCY levels but not mortality. thcy 60-64 methylenetetrahydrofolate reductase Homo sapiens 21-26 10919921-8 2000 4) The C677T transition of the methylenetetrahydrofolate reductase gene causes a moderate increase in tHcy but no or only minor increased CVD risk. thcy 102-106 methylenetetrahydrofolate reductase Homo sapiens 31-66 10780318-10 2000 A 4-week administration of 5-methyltetrahydrofolate (15 mg/day) markedly lowered plasma tHcy in 24 patients with MTHFR 677TT genotype, but the response to treatment correlated with vitamin B,2 levels (p = 0.023). thcy 88-92 methylenetetrahydrofolate reductase Homo sapiens 113-118 10780318-7 2000 tHcy was negatively correlated to folate and vitamin B12 levels, with better correlation found in subjects with the 677TT mutation (r = -0.42 and -0.25) than with the 677CC or CT MTHFR genotype (r = 0).37 and -0.11). thcy 0-4 methylenetetrahydrofolate reductase Homo sapiens 179-184 10780318-9 2000 In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p < or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p < or =0.028). thcy 55-59 methylenetetrahydrofolate reductase Homo sapiens 119-124 10780318-9 2000 In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p < or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p < or =0.028). thcy 55-59 methylenetetrahydrofolate reductase Homo sapiens 173-178 10780318-9 2000 In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p < or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p < or =0.028). thcy 55-59 methylenetetrahydrofolate reductase Homo sapiens 173-178 11860891-10 2000 CONCLUSIONS: Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR. thcy 32-36 methylenetetrahydrofolate reductase Homo sapiens 123-128 11860891-7 2000 Mean plasma tHcy for thermolabile homozygous mutation of MTHFR was significantly higher than that for either heterozygous mutation or wild homozygous mutation (P < 0.001). thcy 12-16 methylenetetrahydrofolate reductase Homo sapiens 57-62 11860891-9 2000 Plasma tHcy was slightly greater in those with lower serum folate than in those with higher one, and correlated inversely with activity of MTHFR. thcy 7-11 methylenetetrahydrofolate reductase Homo sapiens 139-144 11860891-10 2000 CONCLUSIONS: Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR. thcy 32-36 methylenetetrahydrofolate reductase Homo sapiens 89-94 11860891-11 2000 Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR. thcy 81-85 methylenetetrahydrofolate reductase Homo sapiens 102-107 10397696-4 1999 Therefore, we evaluated plasma total homocysteine (tHcy), folate, and vitamin B12 levels and established, by polymerase chain reaction, the presence of the C677T mutation (A223V) in the methylenetetrahydrofolate reductase (MTHFR) gene in 220 cases with VTE without well-established prothrombotic defects. thcy 51-55 methylenetetrahydrofolate reductase Homo sapiens 186-221 10459572-4 1999 The homozygosity for the 677 C --> T mutation of MTHFR was associated with elevated tHcy and low folate levels. thcy 87-91 methylenetetrahydrofolate reductase Homo sapiens 52-57 10563175-3 1999 A frequent mutation (C677T) in the gene coding for the enzyme methyltetrahydrofolate reductase (MTHFR) is often associated with elevated values of tHcy. thcy 147-151 methylenetetrahydrofolate reductase Homo sapiens 62-94 10563175-3 1999 A frequent mutation (C677T) in the gene coding for the enzyme methyltetrahydrofolate reductase (MTHFR) is often associated with elevated values of tHcy. thcy 147-151 methylenetetrahydrofolate reductase Homo sapiens 96-101 10318658-3 1999 We also examined whether vitamin cofactors and the C677T genetic mutation of the methylenetetrahydrofolate reductase (MTHFR) enzyme were major contributors to elevated plasma tHcy and carotid vascular disease. thcy 175-179 methylenetetrahydrofolate reductase Homo sapiens 118-123 10318658-8 1999 Serum and dietary folate levels and the C677T mutation in MTHFR were independent determinants of tHcy (all P=0.0001). thcy 97-101 methylenetetrahydrofolate reductase Homo sapiens 58-63 10323785-4 1999 We focused on tHcy levels in relation to levels of vitamin B12, B6 and folate and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation. thcy 14-18 methylenetetrahydrofolate reductase Homo sapiens 86-121 10323785-4 1999 We focused on tHcy levels in relation to levels of vitamin B12, B6 and folate and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation. thcy 14-18 methylenetetrahydrofolate reductase Homo sapiens 123-128 10323785-5 1999 Multivariate linear analyses adjusted for the presence of vascular disease showed that fasting tHcy was significantly related to folate and vitamin B12, and the presence of the MTHFR TT genotype and the T allele, and to age, smoking habits, and serum levels of creatinine. thcy 95-99 methylenetetrahydrofolate reductase Homo sapiens 177-182 10323785-6 1999 Both post-methionine and delta tHcy levels were related to serum folate levels, and the presence of the MTHFR TT genotype and the T allele, and to postmenopausal status, and body mass index. thcy 31-35 methylenetetrahydrofolate reductase Homo sapiens 104-109 10323785-11 1999 We also found evidence, in patients with premature vascular disease but not in their healthy siblings, for a factor that increases tHcy levels but weakens the normal inverse relation between folate and tHcy and amplifies the effect of the MTHFR genotype. thcy 131-135 methylenetetrahydrofolate reductase Homo sapiens 239-244 9687553-11 1998 This effect was most distinct in women with the highest tHcy concentrations at baseline and in women homozygous for the 677 C-->T mutation of the MTHFR-gene. thcy 56-60 methylenetetrahydrofolate reductase Homo sapiens 149-154 10337865-7 1999 The extent of the plasma tHcy reduction tended to be influenced by the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR). thcy 25-29 methylenetetrahydrofolate reductase Homo sapiens 93-128 10337865-7 1999 The extent of the plasma tHcy reduction tended to be influenced by the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR). thcy 25-29 methylenetetrahydrofolate reductase Homo sapiens 130-135 10229730-3 1999 The main objectives of this study of young ischemic stroke patients were (1) to examine fasting and post-methionine load levels of tHcy, (2) to ascertain the genotype frequency of the C677CT mutation in the methylenetetrahydrofolate reductase gene (TT genotype), and (3) to study the possible interaction between plasma tHcy levels and fibrinolytic factors. thcy 320-324 methylenetetrahydrofolate reductase Homo sapiens 207-242 9596662-8 1998 A genotype/phenotype correlation study showed a marked effect of folate on the association between MTHFR genotypes and tHcy. thcy 119-123 methylenetetrahydrofolate reductase Homo sapiens 99-104 9264011-2 1997 Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). thcy 29-33 methylenetetrahydrofolate reductase Homo sapiens 151-186 9550566-6 1998 Median tHcy concentrations were approximately 1 micromol/L higher in men than in women and in older (70 to 74 years) than in younger (65 to 69 years) individuals and higher in those with the TT and CT genotypes for the methylenetetrahydrofolate reductase polymorphism than in those with the CC genotype (10.7 and 10.6 vs 9.6 micromol/L). thcy 7-11 methylenetetrahydrofolate reductase Homo sapiens 219-254 9681281-1 1998 A polymorphism associated with a thermolabile variant (C677T) of the enzyme methylenetetrahydrofolate reductase has been associated with both elevated total homocysteine (tHcy) levels and risk for cardiovascular disease. thcy 171-175 methylenetetrahydrofolate reductase Homo sapiens 76-111 9323065-4 1997 We conducted a cross-sectional analysis of demographics, the diet, tHcy level, presence of the C677T mutation in the methylenetetrahydrofolate reductase gene (a common genetic cause of elevated tHcy) in children, and the prevalence of parental CVD. thcy 194-198 methylenetetrahydrofolate reductase Homo sapiens 117-152 9264011-2 1997 Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). thcy 29-33 methylenetetrahydrofolate reductase Homo sapiens 188-193 9264011-4 1997 We tested the hypothesis that elevation of tHcy plasma levels in hemodialysis patients is influenced by the 677 C to T mutation of the MTHFR gene and examined the relation of the genotype with tHcy, folate and vitamin B12 plasma levels in these patients. thcy 43-47 methylenetetrahydrofolate reductase Homo sapiens 135-140 8873653-4 1996 A point mutation (C677T) in the gene encoding methylenetetrahydrofolate reductase, an enzyme involved in homocysteine remethylation, has been reported to render the enzyme thermolabile and less active and has been associated with elevated tHcy in homozygous carriers (+/+ genotype) as well as with increased risk of premature cardiovascular disease. thcy 239-243 methylenetetrahydrofolate reductase Homo sapiens 46-81 9244205-8 1997 Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes. thcy 107-111 methylenetetrahydrofolate reductase Homo sapiens 54-59 9244205-11 1997 Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population. thcy 68-72 methylenetetrahydrofolate reductase Homo sapiens 26-31 9247365-1 1997 Homozygosity for a 677C-->T mutation at the locus that codes for 5,10-methylenetetrahydrofolate reductase (MTHFR), a folate-dependent crucial enzyme in homocysteine metabolism, may render the enzyme thermolabile and less active and has been associated with increased levels of plasma total homocysteine (tHcy). thcy 307-311 methylenetetrahydrofolate reductase Homo sapiens 68-108 9247365-1 1997 Homozygosity for a 677C-->T mutation at the locus that codes for 5,10-methylenetetrahydrofolate reductase (MTHFR), a folate-dependent crucial enzyme in homocysteine metabolism, may render the enzyme thermolabile and less active and has been associated with increased levels of plasma total homocysteine (tHcy). thcy 307-311 methylenetetrahydrofolate reductase Homo sapiens 110-115 9247365-10 1997 Our study indicates that homozygosity for the 677C-->T MTHFR mutation, especially in combination with low folate status, predisposes to high plasma levels of fasting tHcy. thcy 169-173 methylenetetrahydrofolate reductase Homo sapiens 58-63 34707639-0 2021 Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population. thcy 157-161 methylenetetrahydrofolate reductase Homo sapiens 77-82 34707639-4 2021 The ExWAS identified two loci, 1p36.22 (lead single-nucleotide polymorphism (SNP) rs1801133, MTHFR C677T) and 16q24.3 (rs1126464, DPEP1), showing exome-wide significant association with tHCY (p < 5E-7); and both loci have been previously associated with tHCY in non-East Asian populations. thcy 186-190 methylenetetrahydrofolate reductase Homo sapiens 93-98