PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19285843-5	2009	Spearman rank correlation was used to analyse the relationship between the degree of methylation in ER-alpha gene and the level of tHcy.	thcy	131-135	estrogen receptor 1	Homo sapiens	100-108	
19285843-10	2009	The spearman rank correlation analysis explored an obvious correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r=0.809, p<0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	139-143	estrogen receptor 1	Homo sapiens	108-116	
19285843-10	2009	The spearman rank correlation analysis explored an obvious correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r=0.809, p<0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	273-277	estrogen receptor 1	Homo sapiens	108-116	
19285843-13	2009	CONCLUSION: Hypermethylation of CpG islands in ER-alpha gene promoter region was found in much higher frequency in atherosclerosis patients, which is positively correlated with the increased level of plasma tHcy and the severity of atherosclerotic lesion, and the in vitro experimental results further extended above clinical data that HHcy can lead to the hypermethylation of ER-alpha gene, and hence to promote the occurrence and development of As.	thcy	207-211	estrogen receptor 1	Homo sapiens	47-55	
18646531-1	2008	OBJECTIVE: To investigate the methylation status in promoter region of ER-alpha gene and the relationship beteen the degree of methylation in ER-alpha gene and the level of total plasma homocysteine(tHcy) in atherosclerosis patients.	thcy	199-203	estrogen receptor 1	Homo sapiens	71-79	
18646531-9	2008	The spearman rank correlation analysis explored an obviously correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r = 0.809, P < 0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	279-283	estrogen receptor 1	Homo sapiens	110-118	
18646531-10	2008	CONCLUSION: Hyermethylation of CpG islands in ER-alpha gene promoter region was found in high frequency in atherosclerosis patients, which is positive correlated with the increased level of plasma tHcy and the severity of atherosclerotic lesion.	thcy	197-201	estrogen receptor 1	Homo sapiens	46-54	
18646531-1	2008	OBJECTIVE: To investigate the methylation status in promoter region of ER-alpha gene and the relationship beteen the degree of methylation in ER-alpha gene and the level of total plasma homocysteine(tHcy) in atherosclerosis patients.	thcy	199-203	estrogen receptor 1	Homo sapiens	142-150	
18646531-5	2008	Using spearman rank correlation to analyse the relatinship between the degree of methylation in ER-alpha gene and the level of tHcy.	thcy	127-131	estrogen receptor 1	Homo sapiens	96-104	
18646531-9	2008	The spearman rank correlation analysis explored an obviously correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r = 0.809, P < 0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	141-145	estrogen receptor 1	Homo sapiens	110-118