PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33471797-4 2021 In this study, PFOS was observed to mediate the increase in reactive oxygen species (ROS) generation, followed by the activation of the extracellular-signal-regulated kinase 1/2 (ERK1/2) pathway, which induced autophagy in RTCs. perfluorooctane sulfonic acid 15-19 mitogen-activated protein kinase 1 Homo sapiens 136-177 33297189-7 2021 Notably, the molecular docking findings indicated that TP53, MAPK1, and ESR1 were potent pharmacological targets of VC against PFOS-associated leukemia. perfluorooctane sulfonic acid 127-131 mitogen-activated protein kinase 1 Homo sapiens 61-66 33297189-10 2021 The validated genes of TP53, MAPK1, ESR1 may become potential biomarkers for monitoring and treating PFOS-associated leukemia. perfluorooctane sulfonic acid 101-105 mitogen-activated protein kinase 1 Homo sapiens 29-34 32700164-2 2020 Here, we demonstrate that exposure to PFOS (10 microM) and PFOA (100 microM)-two contaminants ubiquitously found in human blood-for 72 h induced breast epithelial cell (MCF-10A cell line) proliferation and alteration of regulatory cell-cycle proteins (cyclin D1, CDK6, p21, p53, p27, ERK 1/2 and p38) that persisted after a multitude of cell divisions. perfluorooctane sulfonic acid 38-42 mitogen-activated protein kinase 1 Homo sapiens 296-299 26086160-0 2015 Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure. perfluorooctane sulfonic acid 111-115 mitogen-activated protein kinase 1 Homo sapiens 64-67 26086160-0 2015 Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure. perfluorooctane sulfonic acid 111-115 mitogen-activated protein kinase 1 Homo sapiens 72-76 26086160-6 2015 We also discovered that there was rapid activation of the ERK/JNK MAPK signaling pathway in the HAPI microglia following PFOS treatment. perfluorooctane sulfonic acid 121-125 mitogen-activated protein kinase 1 Homo sapiens 58-61 26086160-6 2015 We also discovered that there was rapid activation of the ERK/JNK MAPK signaling pathway in the HAPI microglia following PFOS treatment. perfluorooctane sulfonic acid 121-125 mitogen-activated protein kinase 1 Homo sapiens 66-70 26086160-7 2015 Moreover, the PFOS-induced iNOS expression and NO production were attenuated after the inhibition of ERK or JNK MAPK by their corresponding inhibitors, PD98059 and SP600125. perfluorooctane sulfonic acid 14-18 mitogen-activated protein kinase 1 Homo sapiens 101-104 26086160-7 2015 Moreover, the PFOS-induced iNOS expression and NO production were attenuated after the inhibition of ERK or JNK MAPK by their corresponding inhibitors, PD98059 and SP600125. perfluorooctane sulfonic acid 14-18 mitogen-activated protein kinase 1 Homo sapiens 112-116 26086160-8 2015 Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway. perfluorooctane sulfonic acid 135-139 mitogen-activated protein kinase 1 Homo sapiens 95-98 26086160-8 2015 Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway. perfluorooctane sulfonic acid 135-139 mitogen-activated protein kinase 1 Homo sapiens 191-194 26086160-8 2015 Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway. perfluorooctane sulfonic acid 135-139 mitogen-activated protein kinase 1 Homo sapiens 107-111 26649298-0 2015 PFOS Disturbs BDNF-ERK-CREB Signalling in Association with Increased MicroRNA-22 in SH-SY5Y Cells. perfluorooctane sulfonic acid 0-4 mitogen-activated protein kinase 1 Homo sapiens 19-22 26649298-3 2015 We hypothesized that PFOS suppresses BDNF expression to produce its neurotoxic effects by inhibiting the ERK-CREB pathway. perfluorooctane sulfonic acid 21-25 mitogen-activated protein kinase 1 Homo sapiens 105-108 26649298-10 2015 PFOS may inhibit BDNF-ERK-CREB signalling by increasing miR-22 levels, which may, in part, explain the mechanism of PFOS neurotoxicity. perfluorooctane sulfonic acid 0-4 mitogen-activated protein kinase 1 Homo sapiens 22-25 22990021-6 2013 PFOS exposure selectively increased activation of ERK that remained above control over 6 h. The inhibitor of ERK pathway, PD98059, substantially blocked caspase-3 activation induced by PFOS, whereas inhibitors of JNK and p38 MAPK, SP600125 and SB203580, respectively, had no effect. perfluorooctane sulfonic acid 0-4 mitogen-activated protein kinase 1 Homo sapiens 50-53 22990021-6 2013 PFOS exposure selectively increased activation of ERK that remained above control over 6 h. The inhibitor of ERK pathway, PD98059, substantially blocked caspase-3 activation induced by PFOS, whereas inhibitors of JNK and p38 MAPK, SP600125 and SB203580, respectively, had no effect. perfluorooctane sulfonic acid 0-4 mitogen-activated protein kinase 1 Homo sapiens 109-112 22990021-6 2013 PFOS exposure selectively increased activation of ERK that remained above control over 6 h. The inhibitor of ERK pathway, PD98059, substantially blocked caspase-3 activation induced by PFOS, whereas inhibitors of JNK and p38 MAPK, SP600125 and SB203580, respectively, had no effect. perfluorooctane sulfonic acid 185-189 mitogen-activated protein kinase 1 Homo sapiens 50-53 22990021-6 2013 PFOS exposure selectively increased activation of ERK that remained above control over 6 h. The inhibitor of ERK pathway, PD98059, substantially blocked caspase-3 activation induced by PFOS, whereas inhibitors of JNK and p38 MAPK, SP600125 and SB203580, respectively, had no effect. perfluorooctane sulfonic acid 185-189 mitogen-activated protein kinase 1 Homo sapiens 109-112 22990021-7 2013 PKC inhibitors, bisindolylmaleimide I and Go6976, dampened caspase-3 activity and ERK activation induced by PFOS. perfluorooctane sulfonic acid 108-112 mitogen-activated protein kinase 1 Homo sapiens 82-85 22990021-8 2013 Collectively, it is suggested that PKC and ERK play proapoptotic roles in PFOS-induced apoptosis of cerebellar granule cells and PKC act as an upstream regulator of ERK activation. perfluorooctane sulfonic acid 74-78 mitogen-activated protein kinase 1 Homo sapiens 43-46