PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22245121-16 2012 Given the markedly lower or absent response of human hepatocytes to the proliferative stimulus from activation of PPARalpha and CAR/PXR, the hepatocellular proliferative response from activation of these receptors by PFOS observed in rats is not expected to be of human relevance. perfluorooctane sulfonic acid 217-221 peroxisome proliferator activated receptor alpha Homo sapiens 114-123 21723365-3 2011 The biological activity of PFOA and PFOS in rodents is attributed primarily to transactivation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARA), which is an important regulator of lipid and carbohydrate metabolism. perfluorooctane sulfonic acid 36-40 peroxisome proliferator activated receptor alpha Homo sapiens 169-174 22047537-1 2011 In animals, perfluorinated chemicals (PFCs), specifically perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS), function as peroxisome proliferator-activated receptor (PPAR) alpha agonists. perfluorooctane sulfonic acid 117-121 peroxisome proliferator activated receptor alpha Homo sapiens 136-178 22047537-1 2011 In animals, perfluorinated chemicals (PFCs), specifically perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS), function as peroxisome proliferator-activated receptor (PPAR) alpha agonists. perfluorooctane sulfonic acid 117-121 peroxisome proliferator activated receptor alpha Homo sapiens 180-184 21726938-11 2011 It may serve as an assistant of LC-MS for prescreening of PPARalpha ligands like PFOS. perfluorooctane sulfonic acid 81-85 peroxisome proliferator activated receptor alpha Homo sapiens 58-67 21345559-2 2011 PFOS can bind to peroxisomal proliferator-activated receptor-alpha (PPARalpha), which forms heterodimers with retinoid X receptors (RXRs) and binds to PPAR response elements. perfluorooctane sulfonic acid 0-4 peroxisome proliferator activated receptor alpha Homo sapiens 68-77 21345559-2 2011 PFOS can bind to peroxisomal proliferator-activated receptor-alpha (PPARalpha), which forms heterodimers with retinoid X receptors (RXRs) and binds to PPAR response elements. perfluorooctane sulfonic acid 0-4 peroxisome proliferator activated receptor alpha Homo sapiens 68-72 21345559-3 2011 In this bioassay free PFOS in water samples competes with immobilized PFOS in ELISA plates for a given amount of PPARalpha-RXRalpha. perfluorooctane sulfonic acid 22-26 peroxisome proliferator activated receptor alpha Homo sapiens 113-122 21345559-3 2011 In this bioassay free PFOS in water samples competes with immobilized PFOS in ELISA plates for a given amount of PPARalpha-RXRalpha. perfluorooctane sulfonic acid 70-74 peroxisome proliferator activated receptor alpha Homo sapiens 113-122 21345559-4 2011 It can be determined indirectly by immobilizing PPARalpha-RXRalpha-PFOS complex to another plate coated with PPARalpha antibody and subsequent measuring the level of PPARalpha-RXRalpha by using biotin-modified PPARalpha-RXRalpha probes-quantum dots-streptavidin detection system. perfluorooctane sulfonic acid 67-71 peroxisome proliferator activated receptor alpha Homo sapiens 48-57 21345559-4 2011 It can be determined indirectly by immobilizing PPARalpha-RXRalpha-PFOS complex to another plate coated with PPARalpha antibody and subsequent measuring the level of PPARalpha-RXRalpha by using biotin-modified PPARalpha-RXRalpha probes-quantum dots-streptavidin detection system. perfluorooctane sulfonic acid 67-71 peroxisome proliferator activated receptor alpha Homo sapiens 109-118 21345559-4 2011 It can be determined indirectly by immobilizing PPARalpha-RXRalpha-PFOS complex to another plate coated with PPARalpha antibody and subsequent measuring the level of PPARalpha-RXRalpha by using biotin-modified PPARalpha-RXRalpha probes-quantum dots-streptavidin detection system. perfluorooctane sulfonic acid 67-71 peroxisome proliferator activated receptor alpha Homo sapiens 109-118 21345559-4 2011 It can be determined indirectly by immobilizing PPARalpha-RXRalpha-PFOS complex to another plate coated with PPARalpha antibody and subsequent measuring the level of PPARalpha-RXRalpha by using biotin-modified PPARalpha-RXRalpha probes-quantum dots-streptavidin detection system. perfluorooctane sulfonic acid 67-71 peroxisome proliferator activated receptor alpha Homo sapiens 109-118 15071170-5 2004 Perfluorooctanesulfonate (PFOS), an end-stage metabolite common to several PFOSAs, was found to activate both mouse and human PPARalpha in a COS-1 cell-based luciferase reporter trans-activation assay. perfluorooctane sulfonic acid 0-24 peroxisome proliferator activated receptor alpha Homo sapiens 126-135 19407336-2 2009 Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid elicit a number of potential toxicities in rodents, the most prevalent of which are governed by activation of the peroxisome proliferator-activated receptor alpha (PPARalpha). perfluorooctane sulfonic acid 34-63 peroxisome proliferator activated receptor alpha Homo sapiens 178-226 19407336-2 2009 Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid elicit a number of potential toxicities in rodents, the most prevalent of which are governed by activation of the peroxisome proliferator-activated receptor alpha (PPARalpha). perfluorooctane sulfonic acid 34-63 peroxisome proliferator activated receptor alpha Homo sapiens 228-237 18996469-4 2009 PPARs are relevant to the study of the biological effects of the perfluorinated alkyl acids as these compounds, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), activate PPARalpha. perfluorooctane sulfonic acid 156-181 peroxisome proliferator activated receptor alpha Homo sapiens 199-208 18996469-4 2009 PPARs are relevant to the study of the biological effects of the perfluorinated alkyl acids as these compounds, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), activate PPARalpha. perfluorooctane sulfonic acid 183-187 peroxisome proliferator activated receptor alpha Homo sapiens 199-208 17047030-0 2007 Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate. perfluorooctane sulfonic acid 131-156 peroxisome proliferator activated receptor alpha Homo sapiens 30-99 17047030-5 2007 In this assay, PFOA had more transactivity than PFOS with both the mouse and human PPAR isoforms. perfluorooctane sulfonic acid 48-52 peroxisome proliferator activated receptor alpha Homo sapiens 83-87 17047030-9 2007 The PPARalpha antagonist, MK-886, significantly suppressed PFOA and PFOS activity of mouse and human PPARalpha. perfluorooctane sulfonic acid 68-72 peroxisome proliferator activated receptor alpha Homo sapiens 101-110 17047030-11 2007 In conclusion, this study characterized the dose response and differential activation of mouse and human PPARalpha, beta/delta, gamma by PFOA and PFOS. perfluorooctane sulfonic acid 146-150 peroxisome proliferator activated receptor alpha Homo sapiens 105-126 15071170-5 2004 Perfluorooctanesulfonate (PFOS), an end-stage metabolite common to several PFOSAs, was found to activate both mouse and human PPARalpha in a COS-1 cell-based luciferase reporter trans-activation assay. perfluorooctane sulfonic acid 26-30 peroxisome proliferator activated receptor alpha Homo sapiens 126-135 15071170-10 2004 The interactions of PPARalpha with PFOS and FOSA, and the potential of these chemicals for activation of unique sets of downstream target genes, may help explain the diverse biological effects exhibited by PFOSAs and may aid in the evaluation of human and environmental risks associated with exposure to this important class of fluorochemicals. perfluorooctane sulfonic acid 35-39 peroxisome proliferator activated receptor alpha Homo sapiens 20-29 25056757-5 2015 Addition of the PPAR-alpha antagonist GW6471 to PFOS-dosed cells stimulated with PHA/PMA resulted in decreases in IL-2 production starting at 50 microg PFOS ml(-1), which suggests PFOS affected T-cell IL-2 production via PPAR-alpha-independent mechanisms. perfluorooctane sulfonic acid 48-52 peroxisome proliferator activated receptor alpha Homo sapiens 16-26 26034840-1 2015 BACKGROUND: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARalpha) subtype activity, which influences lipid metabolism. perfluorooctane sulfonic acid 24-53 peroxisome proliferator activated receptor alpha Homo sapiens 123-171 26034840-1 2015 BACKGROUND: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARalpha) subtype activity, which influences lipid metabolism. perfluorooctane sulfonic acid 24-53 peroxisome proliferator activated receptor alpha Homo sapiens 173-182 26034840-1 2015 BACKGROUND: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARalpha) subtype activity, which influences lipid metabolism. perfluorooctane sulfonic acid 55-59 peroxisome proliferator activated receptor alpha Homo sapiens 123-171 26034840-1 2015 BACKGROUND: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARalpha) subtype activity, which influences lipid metabolism. perfluorooctane sulfonic acid 55-59 peroxisome proliferator activated receptor alpha Homo sapiens 173-182 34861291-0 2022 The role of mouse and human peroxisome proliferator-activated receptor-alpha in modulating the hepatic effects of perfluorooctane sulfonate in mice. perfluorooctane sulfonic acid 114-139 peroxisome proliferator activated receptor alpha Homo sapiens 28-76 34861291-2 2022 In the present work, the specific role of mouse and human PPARalpha in mediating the hepatic effects of PFOS was examined in short-term studies using wild type, Ppara-null and PPARA-humanized mice. perfluorooctane sulfonic acid 104-108 peroxisome proliferator activated receptor alpha Homo sapiens 58-67 33853480-6 2021 From a mechanistic perspective, research on human liver cells shows that PFOS/PFOA activate the PPARalpha pathway, whereas studies on the involvement of other nuclear receptors, like PXR, are less conclusive. perfluorooctane sulfonic acid 73-77 peroxisome proliferator activated receptor alpha Homo sapiens 96-105 25056757-5 2015 Addition of the PPAR-alpha antagonist GW6471 to PFOS-dosed cells stimulated with PHA/PMA resulted in decreases in IL-2 production starting at 50 microg PFOS ml(-1), which suggests PFOS affected T-cell IL-2 production via PPAR-alpha-independent mechanisms. perfluorooctane sulfonic acid 48-52 peroxisome proliferator activated receptor alpha Homo sapiens 221-231 25056757-5 2015 Addition of the PPAR-alpha antagonist GW6471 to PFOS-dosed cells stimulated with PHA/PMA resulted in decreases in IL-2 production starting at 50 microg PFOS ml(-1), which suggests PFOS affected T-cell IL-2 production via PPAR-alpha-independent mechanisms. perfluorooctane sulfonic acid 152-156 peroxisome proliferator activated receptor alpha Homo sapiens 16-26 25056757-5 2015 Addition of the PPAR-alpha antagonist GW6471 to PFOS-dosed cells stimulated with PHA/PMA resulted in decreases in IL-2 production starting at 50 microg PFOS ml(-1), which suggests PFOS affected T-cell IL-2 production via PPAR-alpha-independent mechanisms. perfluorooctane sulfonic acid 152-156 peroxisome proliferator activated receptor alpha Homo sapiens 16-26 23624243-8 2013 PFOS was positively associated with expression of genes involved in both cholesterol mobilisation and transport in women (NCEH1 and PPARA; p=0.003 and 0.039 respectively), but no effects were evident in men. perfluorooctane sulfonic acid 0-4 peroxisome proliferator activated receptor alpha Homo sapiens 132-137