PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21892618-0	2012	HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells.	Zonisamide	25-35	caspase 3	Homo sapiens	61-70	
21892618-3	2012	Here we show that low micromolar concentrations of zonisamide prevented cleavage of caspase-3 and cell death in human dopaminergic SH-SY5Y neuroblastoma cells that were subjected to endoplasmic reticulum stress induced by tunicamycin or 6-hydroxydopamine.	Zonisamide	51-61	caspase 3	Homo sapiens	84-93	
25261037-9	2015	Furthermore, zonisamide inhibited the activation of caspase-3 in vitro.	Zonisamide	13-23	caspase 3	Homo sapiens	52-61	
25261037-10	2015	These results suggest that zonisamide affected ER stress via caspase-3.	Zonisamide	27-37	caspase 3	Homo sapiens	61-70	
25261037-11	2015	We think that ER stress, particularly the mechanism via caspase-3, is involved in part of the neuroprotective effect of zonisamide against the experimental models of Parkinson s disease.	Zonisamide	120-130	caspase 3	Homo sapiens	56-65