PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17420132-5 2007 In particular, our data suggest that a narrower active site cleft, together with a different hydrogen bond network arrangement of hCA VA compared to hCA II, may account for the different Kd values of zonisamide and topiramate toward these physiologically relevant hCA isoforms. Zonisamide 200-210 carbonic anhydrase 5A Homo sapiens 130-136