PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35514993-0 2022 Oleamide-Mediated Polarization of M1 Macrophages and IL-1beta Production by Regulating NLRP3-Inflammasome Activation in Primary Human Monocyte-Derived Macrophages. oleylamide 0-8 NLR family pyrin domain containing 3 Homo sapiens 87-92 35514993-10 2022 Whether oleamide functioned as a second signal that activated the NLRP3 inflammasome and mediated IL-1beta production was further investigated using LPS-primed MDMs followed by oleamide treatment that induced activation of inflammasome-related proteins including NLRP3, ASC, cleaved casp-1, and cleaved IL-1beta. oleylamide 8-16 NLR family pyrin domain containing 3 Homo sapiens 66-71 35514993-10 2022 Whether oleamide functioned as a second signal that activated the NLRP3 inflammasome and mediated IL-1beta production was further investigated using LPS-primed MDMs followed by oleamide treatment that induced activation of inflammasome-related proteins including NLRP3, ASC, cleaved casp-1, and cleaved IL-1beta. oleylamide 8-16 NLR family pyrin domain containing 3 Homo sapiens 263-268 35514993-11 2022 These findings suggested that oleamide promoted M1 macrophage polarization and increased IL-1beta production by activating the NLRP3 inflammasome in primary MDMs. oleylamide 30-38 NLR family pyrin domain containing 3 Homo sapiens 127-132