PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28104929-7	2016	The effects of dapagliflozin on the IL-1beta production in culturing primary macrophages of wild type and NLRP3-/- knockout mice were investigated for mechanism analyses.	dapagliflozin	15-28	interleukin 1 beta	Mus musculus	36-44	
28104929-10	2016	Also, reduced production of IL-1beta, IL-18, NLRP3 protein, and mitochondrial ROS in the aortic tissues was detected with dapagliflozin treatment.	dapagliflozin	122-135	interleukin 1 beta	Mus musculus	28-36	
28104929-13	2016	Dapagliflozin may be of therapeutic potential for diabetic atherosclerosis induced by high-fat diet, and these benefits may depend on the inhibitory effect on the secretion of IL-1beta by macrophages via the ROS-NLRP3-caspase-1 pathway.	dapagliflozin	0-13	interleukin 1 beta	Mus musculus	176-184	
28447181-15	2017	This in vitro study showed that NALP3, ASC, IL-1beta, and caspase-1 mRNA levels were higher in the BTBR cardiofibroblasts and attenuated with Dapa.	dapagliflozin	142-146	interleukin 1 beta	Mus musculus	44-52	
28598954-10	2017	Excitingly, we demonstrate that SGLT2 inhibition with dapagliflozin promoted a trend towards reduced tumour necrosis factor-alpha and elevated IL-1beta protein levels in the kidney.	dapagliflozin	54-67	interleukin 1 beta	Mus musculus	143-151