PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34672772-5 2021 To investigate the underlying mechanisms through which DAP reduces urinary albumin excretion, we used RNA-sequencing (RNA-seq) to analyze gene expression in human kidney 2 (HK-2) cells treated with DAP. dapagliflozin 198-201 hexokinase 2 Homo sapiens 173-177 33048256-3 2021 We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammation via HKII in endothelial cells, and that HKII-dependent inflammation is determined by ERK1/2, NF-kappaB. dapagliflozin 84-97 hexokinase 2 Homo sapiens 130-134 33048256-3 2021 We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammation via HKII in endothelial cells, and that HKII-dependent inflammation is determined by ERK1/2, NF-kappaB. dapagliflozin 84-97 hexokinase 2 Homo sapiens 166-170 33048256-3 2021 We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammation via HKII in endothelial cells, and that HKII-dependent inflammation is determined by ERK1/2, NF-kappaB. dapagliflozin 84-88 hexokinase 2 Homo sapiens 130-134 33048256-3 2021 We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammation via HKII in endothelial cells, and that HKII-dependent inflammation is determined by ERK1/2, NF-kappaB. dapagliflozin 84-88 hexokinase 2 Homo sapiens 166-170 30387082-6 2019 By optimizing the passages of HK-2 cells, 2-NBDG concentration and incubation time, and by measuring glucose uptake treated by Dapagliflozin, a clinical drug of SGLT2 inhibitors, we successfully developed a new assay for measuring glucose uptake through SGLT2. dapagliflozin 127-140 hexokinase 2 Homo sapiens 30-34 34672772-7 2021 The results of the RNA-seq experiments showed 349 differentially expressed genes between DAP-treated HK-2 cells and control cells. dapagliflozin 89-92 hexokinase 2 Homo sapiens 101-105