PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30899391-3 2019 We examined the interactions of metformin and sitagliptin treatment with the JAK2/STAT3 pathway and cardiac remodeling. Sitagliptin Phosphate 46-57 Janus kinase 2 Rattus norvegicus 77-81 30899391-11 2019 The superior cardio-protective effect of metformin over sitagliptin treatment may partly account for the differences we observed in JAK2/STAT3 activation, indicating that measuring JAK2/STAT3 pathway coupled with metformin treatment may give insight into a more promising DM treatment. Sitagliptin Phosphate 56-67 Janus kinase 2 Rattus norvegicus 132-136 30899391-11 2019 The superior cardio-protective effect of metformin over sitagliptin treatment may partly account for the differences we observed in JAK2/STAT3 activation, indicating that measuring JAK2/STAT3 pathway coupled with metformin treatment may give insight into a more promising DM treatment. Sitagliptin Phosphate 56-67 Janus kinase 2 Rattus norvegicus 181-185 29885296-6 2018 Interestingly, sitagliptin pretreatment downregulated the RAGE-JAK2/STAT3 pathway and decreased the expression of CXCL4 and CXCR3. Sitagliptin Phosphate 15-26 Janus kinase 2 Rattus norvegicus 63-67 29885296-8 2018 Altogether, our present data suggest that sitagliptin has an anticonvulsant effect, which might act via downregulation of the CXCL4/CXCR3 axis, followed by a decrease in RAGE and JAK2/STAT3 expression. Sitagliptin Phosphate 42-53 Janus kinase 2 Rattus norvegicus 179-183