PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29498478-5	2018	Here, we investigated the relationship between the five most commonly applied SUs (glibenclamide, gliclazide, glimepiride, glipizide, gliquidone) and OATP1B1 and OATP1B3.	glimepiride	110-121	solute carrier organic anion transporter family member 1B1	Homo sapiens	150-157	
29498478-7	2018	We demonstrated that gliclazide and glimepiride are substrates of OATP1B1 and glibenclamide and glipizide are substrates of OATP1B3.	glimepiride	36-47	solute carrier organic anion transporter family member 1B1	Homo sapiens	66-73	
28260863-9	2017	However, with regard to glimepiride PK, the SLCO1B1 521TC group had a significantly higher maximum plasma concentration (Cmax,ss) and area under the plasma concentration-time curve during the dose interval at steady state (AUCtau,ss) for glimepiride in combination with rosuvastatin than those for glimepiride alone.	glimepiride	24-35	solute carrier organic anion transporter family member 1B1	Homo sapiens	44-51	
30030468-0	2018	CYP2C9 and OATP1B1 genetic polymorphisms affect the metabolism and transport of glimepiride and gliclazide.	glimepiride	80-91	solute carrier organic anion transporter family member 1B1	Homo sapiens	11-18	
30030468-2	2018	The aim of this study was to assess the effect of CYP2C9 and OATP1B1 genetic polymorphisms on the metabolism and transport of glimepiride and gliclazide.	glimepiride	126-137	solute carrier organic anion transporter family member 1B1	Homo sapiens	61-68	
30030468-3	2018	The uptake of glimepiride and gliclazide was measured in OATP1B1*1a, *5 and *15-HEK293T cells, and their metabolism was measured using CYP2C9*1, *2 and *3 recombinase by LC-MS. Glimepiride in OATP1B1*1a, *5 and *15-HEK293T cells had Vmax values of 155 +- 18.7, 80 +- 9.6, and 84.5 +- 8.2 pmol/min/mg, while gliclazide had Vmax values of 15.7 +- 4.6, 7.2 +- 2.5, and 8.7 +- 2.4 pmol/min/mg, respectively.	glimepiride	14-25	solute carrier organic anion transporter family member 1B1	Homo sapiens	57-64	
30030468-4	2018	The clearance of glimepiride and gliclazide in OATP1B1*5 and *15 was significantly reduced compared to the wild-type.	glimepiride	17-28	solute carrier organic anion transporter family member 1B1	Homo sapiens	47-54	
30030468-7	2018	These findings collectively indicate that OATP1B1*5 and *15 and CYP2C9*2 and *3 have a significant effect on the transport and metabolism of glimepiride and gliclazide.	glimepiride	141-152	solute carrier organic anion transporter family member 1B1	Homo sapiens	42-49	
28260863-9	2017	However, with regard to glimepiride PK, the SLCO1B1 521TC group had a significantly higher maximum plasma concentration (Cmax,ss) and area under the plasma concentration-time curve during the dose interval at steady state (AUCtau,ss) for glimepiride in combination with rosuvastatin than those for glimepiride alone.	glimepiride	238-249	solute carrier organic anion transporter family member 1B1	Homo sapiens	44-51	
28260863-9	2017	However, with regard to glimepiride PK, the SLCO1B1 521TC group had a significantly higher maximum plasma concentration (Cmax,ss) and area under the plasma concentration-time curve during the dose interval at steady state (AUCtau,ss) for glimepiride in combination with rosuvastatin than those for glimepiride alone.	glimepiride	238-249	solute carrier organic anion transporter family member 1B1	Homo sapiens	44-51	
28260863-11	2017	In conclusion, there were no significant PK interactions between the two drugs; however, the exposure to glimepiride could be affected by rosuvastatin in the presence of the SLCO1B1 polymorphism.	glimepiride	105-116	solute carrier organic anion transporter family member 1B1	Homo sapiens	174-181