PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29070884-0	2017	Telmisartan Activates PPARdelta to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice.	Telmisartan	0-11	peroxisome proliferator activator receptor delta	Mus musculus	22-31	
29070884-3	2017	Telmisartan was recently shown to activate PPARdelta expression; therefore, the effectiveness of telmisartan in treating depression was investigated.	Telmisartan	0-11	peroxisome proliferator activator receptor delta	Mus musculus	43-52	
29070884-5	2017	Telmisartan also reversed the decrease in PPARdelta and 5-HTT levels in the hippocampus of depression-like mice.	Telmisartan	0-11	peroxisome proliferator activator receptor delta	Mus musculus	42-51	
29070884-6	2017	Administration of PPARdelta antagonist GSK0660 and direct infusion of sh-PPARdelta into the brain blocked the effects of telmisartan on the improvement of depression-like behavior in these mice.	Telmisartan	121-132	peroxisome proliferator activator receptor delta	Mus musculus	18-27	
29070884-6	2017	Administration of PPARdelta antagonist GSK0660 and direct infusion of sh-PPARdelta into the brain blocked the effects of telmisartan on the improvement of depression-like behavior in these mice.	Telmisartan	121-132	peroxisome proliferator activator receptor delta	Mus musculus	73-82	
29070884-7	2017	Moreover, telmisartan enhanced the expression of PPARdelta and 5HTT in H19-7 cells.	Telmisartan	10-21	peroxisome proliferator activator receptor delta	Mus musculus	49-58	
29070884-8	2017	In conclusion, the obtained results suggest that telmisartan improves symptoms of stress-induced depression in animals under chronic stress through activation of PPARdelta.	Telmisartan	49-60	peroxisome proliferator activator receptor delta	Mus musculus	162-171	
24352213-1	2014	Telmisartan, an angiotensin II receptor type 1 blocker (ARB), was recently reported to promote lipolysis in mice by acting as a peroxisome proliferator-activated receptor (PPAR)-delta activator, although in clinical studies, it has also been recognized to activate PPAR-gamma as a major cause of its pleiotropic actions.	Telmisartan	0-11	peroxisome proliferator activator receptor delta	Mus musculus	128-183	
23238297-8	2013	The protein levels of PPARdelta, phospho-Akt, phospho-AS160, and Glut4 translocation to the plasma membrane in the skeletal muscle on insulin stimulation were reduced by high-fat diet and were restored by telmisartan administration in wild-type mice.	Telmisartan	205-216	peroxisome proliferator activator receptor delta	Mus musculus	22-31	
20477906-3	2011	Administration of telmisartan up-regulated levels of PPAR-delta and phospho-AMPKalpha in cultured myotubes.	Telmisartan	18-29	peroxisome proliferator activator receptor delta	Mus musculus	53-63	
20477906-5	2011	Chronic administration of telmisartan remarkably prevented weight gain, enhanced running endurance and post-exercise oxygen consumption, and increased slow-twitch skeletal muscle fibres in wild-type mice, but these effects were absent in PPAR-delta-deficient mice.	Telmisartan	26-37	peroxisome proliferator activator receptor delta	Mus musculus	238-248	
30850637-7	2019	The downstream targets of PPARalpha, PPARdelta, and RELA in this network significantly overlapped with telmisartan-induced differentially expressed genes (DEGs), which were verified in palmitate-treated Hepa1c1c7 cell line.	Telmisartan	103-114	peroxisome proliferator activator receptor delta	Mus musculus	37-46	
20176998-0	2010	Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways.	Telmisartan	0-11	peroxisome proliferator activator receptor delta	Mus musculus	67-115	
20176998-2	2010	In the present study we tested the hypothesis that telmisartan prevents adipogenesis in vitro and weight gain in vivo through activation of peroxisome proliferator-activated receptor (PPAR)-delta-dependent pathways in several tissues.	Telmisartan	51-62	peroxisome proliferator activator receptor delta	Mus musculus	140-195	
20176998-8	2010	Telmisartan-associated reduction of adipogenesis in preadipocytes was significantly blocked after PPAR-delta gene knockout.	Telmisartan	0-11	peroxisome proliferator activator receptor delta	Mus musculus	98-108	
20176998-10	2010	We conclude that telmisartan prevents adipogenesis and weight gain through activation of PPAR-delta-dependent lipolytic pathways and energy uncoupling in several tissues.	Telmisartan	17-28	peroxisome proliferator activator receptor delta	Mus musculus	89-99