PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32893519-6	2020	RESULTS: Telmisartan decreased VSMC proliferation, which was accompanied by decreased phosphorylations of mammalian target of rapamycin (mTOR) at Ser2448 (p-mTOR-Ser2448) and p70 S6 kinase (p70S6K) at Thr389 (p-p70S6K-Thr389) in dose- and time-dependent manners.	Telmisartan	9-20	ribosomal protein S6 kinase B1	Homo sapiens	175-188	
32893519-6	2020	RESULTS: Telmisartan decreased VSMC proliferation, which was accompanied by decreased phosphorylations of mammalian target of rapamycin (mTOR) at Ser2448 (p-mTOR-Ser2448) and p70 S6 kinase (p70S6K) at Thr389 (p-p70S6K-Thr389) in dose- and time-dependent manners.	Telmisartan	9-20	ribosomal protein S6 kinase B1	Homo sapiens	190-196	
32893519-6	2020	RESULTS: Telmisartan decreased VSMC proliferation, which was accompanied by decreased phosphorylations of mammalian target of rapamycin (mTOR) at Ser2448 (p-mTOR-Ser2448) and p70 S6 kinase (p70S6K) at Thr389 (p-p70S6K-Thr389) in dose- and time-dependent manners.	Telmisartan	9-20	ribosomal protein S6 kinase B1	Homo sapiens	211-217	
32893519-8	2020	Co-treatment with compound C, a specific AMPK inhibitor, or ectopic expression of the dn-AMPKalpha1 gene, significantly reversed telmisartan-inhibited VSMC proliferation, p-mTOR-Ser2448 and p-p70S6K-Thr389 levels.	Telmisartan	129-140	ribosomal protein S6 kinase B1	Homo sapiens	192-198	
32893519-9	2020	Among the ARBs tested (including losartan and fimasartan), only telmisartan increased p-AMPK-Thr172 and decreased p-mTOR-Ser2448, p-p70S6K-Thr389, and VSMC proliferation.	Telmisartan	64-75	ribosomal protein S6 kinase B1	Homo sapiens	132-138	
32893519-12	2020	CONCLUSION: These results demonstrated that telmisartan-activated AMPK inhibited basal and PDGF-stimulated VSMC proliferation, at least in part, by downregulating the mTOR/p70S6K signaling axis in a PPARgamma-independent manner.	Telmisartan	44-55	ribosomal protein S6 kinase B1	Homo sapiens	172-178