PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21825230-4 2011 GW0742 induced a progressive reduction in systolic arterial blood pressure and heart rate in SHRs and reduced the mesenteric arterial remodeling, the increased aortic vasoconstriction to angiotensin II, and the endothelial dysfunction characteristic of SHRs. GW0742 0-6 angiotensinogen Rattus norvegicus 187-201 21825230-6 2011 Moreover, GW0742 inhibited vascular superoxide production, downregulated p22(phox) and p47(phox) proteins, decreased both basal and angiotensin II-stimulated NADPH oxidase activity, inhibited extracellular-regulated kinase 1/2 activation, and reduced the expression of the proinflammatory and proatherogenic genes, interleukin 1beta, interleukin 6, or intercellular adhesion molecule 1. GW0742 10-16 angiotensinogen Rattus norvegicus 132-146