PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18627005-5 2008 GW0742 and PPARdelta overexpression in hepatocytes induced the expression of insulin-induced gene-1 (Insig-1), an endoplasmic reticulum protein braking SREBP activation, at both the mRNA and the protein levels. GW0742 0-6 insulin induced gene 1 Mus musculus 77-99 18627005-5 2008 GW0742 and PPARdelta overexpression in hepatocytes induced the expression of insulin-induced gene-1 (Insig-1), an endoplasmic reticulum protein braking SREBP activation, at both the mRNA and the protein levels. GW0742 0-6 insulin induced gene 1 Mus musculus 101-108 18627005-9 2008 Knockdown of endogenous Insig-1 attenuated the suppressive effect of GW0742 on SREBP-1 and its target genes, indicating PPARdelta inhibited SREBP-1 activation via induction of Insig-1. GW0742 69-75 insulin induced gene 1 Mus musculus 24-31