PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31637187-8	2019	Also, PTL increased Cyclin inhibition protein 1 (P21), Bcl-2-associated X protein (Bax), Cysteinyl aspartate specific proteinas-3 (Caspase-3) and Caspase-9 expression.	parthenolide	6-9	H3 histone pseudogene 16	Homo sapiens	49-52	
23037503-2	2012	We investigated whether the NF-kB inhibitor, parthenolide, currently in cancer clinical trials, attenuates tumor promotion by modulating the epigenetically regulated NF-kB target genes, p21 and cyclin D1.	parthenolide	45-57	H3 histone pseudogene 16	Homo sapiens	186-189	
23037503-0	2012	Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21.	parthenolide	33-45	H3 histone pseudogene 16	Homo sapiens	72-75	
23037503-5	2012	Furthermore, parthenolide decreased tumor promoter-induced NF-kB activity, increased p21, and decreased cyclin D1 expression.	parthenolide	13-25	H3 histone pseudogene 16	Homo sapiens	85-88	
23037503-6	2012	In parthenolide-treated cells, p21 transcription correlated with relaxed chromatin and p65/NF-kB binding at the p21 promoter.	parthenolide	3-15	H3 histone pseudogene 16	Homo sapiens	31-34	
23037503-6	2012	In parthenolide-treated cells, p21 transcription correlated with relaxed chromatin and p65/NF-kB binding at the p21 promoter.	parthenolide	3-15	H3 histone pseudogene 16	Homo sapiens	112-115	
23037503-9	2012	Because p21 expression by parthenolide was sustained, we used p21-siRNA and p21 -/- cancer cells and showed that the loss of p21 is cytoprotective against parthenolide.	parthenolide	26-38	H3 histone pseudogene 16	Homo sapiens	8-11	
23037503-12	2012	These results show that low doses of parthenolide inhibit tumor promotion and epigenetically modulate p21 expression, highlighting the potential role of this drug as a chemopreventive agent and in epigenetic cancer therapy.	parthenolide	37-49	H3 histone pseudogene 16	Homo sapiens	102-105	
16705314-2	2006	We have previously demonstrated that either Calphostin C (CC) (a protein kinase C (PKC) inhibitor) or Parthenolide (an NF-kappaB inhibitor) abrogates HDACI-induced transcriptional activation of NF-kappaB and p21, which is associated with profound potentiation of HDACI-mediated induction of apoptosis.	parthenolide	102-114	H3 histone pseudogene 16	Homo sapiens	208-211