PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15956258-4	2005	Parthenolide was effective either alone or in combination with docetaxel in reducing colony formation, inducing apoptosis and reducing the expression of prometastatic genes IL-8 and the antiapoptotic gene GADD45beta1 in vitro.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	173-177	
17290398-9	2007	Subcutaneous injection or oral administration of parthenolide showed significant tumor growth inhibition in the xenograft model via decreased production of interleukin-8 (IL-8) or vascular endothelial growth factor (VEGF).	parthenolide	49-61	C-X-C motif chemokine ligand 8	Homo sapiens	156-169	
17290398-9	2007	Subcutaneous injection or oral administration of parthenolide showed significant tumor growth inhibition in the xenograft model via decreased production of interleukin-8 (IL-8) or vascular endothelial growth factor (VEGF).	parthenolide	49-61	C-X-C motif chemokine ligand 8	Homo sapiens	171-175	
23403077-9	2013	Further mechanistic studies revealed that the gene expression of CXCL8 could be reduced by the MIF specific small interfering RNA (siRNA) or NF-kappaB inhibitor parthenolide, and the growth of tumor spheres was also reduced after MIF siRNA transfection.	parthenolide	161-173	C-X-C motif chemokine ligand 8	Homo sapiens	65-70	
23826669-8	2014	Parthenolide pretreatment also abolished IL-8 mRNA and protein induction by palmitate.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	41-45	
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	parthenolide	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	parthenolide	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	parthenolide	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	193-197	
10704251-5	2000	Pretreatment with either isohelenin or parthenolide inhibited TNF-alpha-mediated IL-8 gene expression in a concentration-dependent manner.	parthenolide	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	81-85	
23876538-12	2013	RESULT(S): With parthenolide pretreatment, TNF-alpha-induced IL-8 gene and protein expression in ESCs were diminished.	parthenolide	16-28	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
21992677-0	2011	Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	86-90	
23086737-1	2013	The aims of this study were to assess the effects and potential mechanisms of parthenolide on the expression of vascular endothelial growth factor (VEGF), interleukin 8 (IL-8) and matrix metalloproteinase 9 (MMP-9) in human breast cancer cell line MDA-MB-231.	parthenolide	78-90	C-X-C motif chemokine ligand 8	Homo sapiens	155-168	
23086737-1	2013	The aims of this study were to assess the effects and potential mechanisms of parthenolide on the expression of vascular endothelial growth factor (VEGF), interleukin 8 (IL-8) and matrix metalloproteinase 9 (MMP-9) in human breast cancer cell line MDA-MB-231.	parthenolide	78-90	C-X-C motif chemokine ligand 8	Homo sapiens	170-174	
23086737-5	2013	The real-time PCR and Western blot data showed that the expressions of VEGF, IL-8 and MMP-9 were significantly inhibited by parthenolide at both transcription level and protein level in MDA-MB-231 cells.	parthenolide	124-136	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
23086737-8	2013	Hence, the expression of VEGF, IL-8 and MMP-9 may be suppressed by parthenolide through the inhibition of NF-kappaB DNA-binding activity in MDA-MB-231 cells.	parthenolide	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	31-35	
22884152-9	2012	Parthenolide decreased the levels of the angiogenic factors MMP-9, VEGF, and IL-8 secreted by the MDA-MB-231 cells.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
21992677-11	2011	Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation.	parthenolide	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	64-68	
21992677-11	2011	Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation.	parthenolide	162-174	C-X-C motif chemokine ligand 8	Homo sapiens	64-68	
21992677-12	2011	Using a luciferase promoter assay, our studies showed that parthenolide decreased activation of the IL-8 promoter in CF cells stimulated with TNFalpha/IL-1beta.	parthenolide	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	100-104	
21992677-14	2011	Parthenolide inhibited both NFkappaB and MAPK/AP-1 pathways contributing to the inhibition of IL-8 production.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
20870895-13	2011	The NF-kappaB inhibitors gliotoxin and parthenolide increased apoptosis and decreased IL-8 and CXCR2 expression.	parthenolide	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	86-90	
21179282-8	2010	Treatment with inhibitors of nuclear factor-kappaB (NF-kappaB), i.e., pyrrolidine dithiocarbamate and parthenolide, abrogated the stimulatory effect of poly (I:C) on the production of VEGF and IL-8 in RA FLS.	parthenolide	102-114	C-X-C motif chemokine ligand 8	Homo sapiens	193-197	
20134045-7	2009	Inhibition of NF-kappaB with curcumin or parthenolide resulted in a decrease of IL-8 secretion.	parthenolide	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	80-84