PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20578985-5 2010 An examination of pathways common to Paclitaxel and parthenolide signaling revealed that this synergy was related to modulation of the NF-kappaB/ I-kappaB kinase (IKK) signal cascade through IKKbeta. parthenolide 52-64 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 191-198 10553091-3 1999 This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the TNF-alpha-induced induction of I kappa B kinase (IKK) and IKK beta, without affecting the activation of p38 and c-Jun N-terminal kinase. parthenolide 48-60 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 185-193 20649582-5 2010 KEY RESULTS: Two IKKbeta inhibitors were found to be highly effective and non-toxic inhibitors of choriodecidual cytokine production: parthenolide and [5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1). parthenolide 134-146 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 17-24