PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25439190-7	2015	RESULTS: We established that PAR, as a prototype compound, suppressed lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha-induced increases in matrix metalloproteinase (MMP)-1, MMP-3, inducible nitric oxide synthase (iNOS), and interleukin (IL)-1beta mRNA in chondrocytes.	parthenolide	29-32	nitric oxide synthase 2	Rattus norvegicus	197-228	
25439190-7	2015	RESULTS: We established that PAR, as a prototype compound, suppressed lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha-induced increases in matrix metalloproteinase (MMP)-1, MMP-3, inducible nitric oxide synthase (iNOS), and interleukin (IL)-1beta mRNA in chondrocytes.	parthenolide	29-32	nitric oxide synthase 2	Rattus norvegicus	230-234	
12417429-5	2002	Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.	parthenolide	103-115	nitric oxide synthase 2	Rattus norvegicus	70-74	
12417429-0	2002	Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells.	parthenolide	80-92	nitric oxide synthase 2	Rattus norvegicus	59-63	
12417429-3	2002	Here, we investigated the effect of parthenolide on inducible NO synthase (iNOS) synthesis and NO release using primary rat microglia.	parthenolide	36-48	nitric oxide synthase 2	Rattus norvegicus	52-73	
12417429-3	2002	Here, we investigated the effect of parthenolide on inducible NO synthase (iNOS) synthesis and NO release using primary rat microglia.	parthenolide	36-48	nitric oxide synthase 2	Rattus norvegicus	75-79	
12417429-4	2002	We found parthenolide to be an inhibitor of iNOS/NO synthesis.	parthenolide	9-21	nitric oxide synthase 2	Rattus norvegicus	44-48	
12417429-5	2002	Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.	parthenolide	48-60	nitric oxide synthase 2	Rattus norvegicus	70-74	
10462483-5	1999	In the current studies we determined if the sesquiterpene lactones, parthenolide and isohelenin, modulate iNOS gene expression in cultured rat aortic smooth muscle cells (RASMC) treated with lipopolysaccharide and interferon-gamma.	parthenolide	68-80	nitric oxide synthase 2	Rattus norvegicus	106-110	
10462483-6	1999	Treatment with parthenolide or isohelenin inhibited NO production and iNOS mRNA expression in a concentration-dependent manner.	parthenolide	15-27	nitric oxide synthase 2	Rattus norvegicus	70-74	
10462483-7	1999	Transient transfection studies with an iNOS promoter-luciferase reporter plasmid demonstrated that parthenolide and isohelenin also inhibited activation of the iNOS promoter.	parthenolide	99-111	nitric oxide synthase 2	Rattus norvegicus	39-43	
10462483-7	1999	Transient transfection studies with an iNOS promoter-luciferase reporter plasmid demonstrated that parthenolide and isohelenin also inhibited activation of the iNOS promoter.	parthenolide	99-111	nitric oxide synthase 2	Rattus norvegicus	160-164	
11961112-13	2002	Treatment with parthenolide also abolished nitrotyrosine formation, PARS expression, and apoptosis and reduced iNOS mRNA content in thoracic aortas.	parthenolide	15-27	nitric oxide synthase 2	Rattus norvegicus	111-115