PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11921057-8	2002	IkappaBalpha degradation, NF-kappaB activation, and iNOS expression were attenuated by parthenolide (3mg/kg), the active constituent of feverfew, an anti-inflammatory drug used for migraine treatment.	parthenolide	87-99	nitric oxide synthase 2	Homo sapiens	52-56	
10874135-0	2000	Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1.	parthenolide	14-26	nitric oxide synthase 2	Homo sapiens	82-113	
10874135-4	2000	In this study, we demonstrate that parthenolide, the predominant sesquiterpene lactone in European feverfew (Tanacetum parthenium), exerts potent inhibitory effects on the promoter activity of the iNOS gene in THP-1 cells.	parthenolide	35-47	nitric oxide synthase 2	Homo sapiens	197-201	
10874135-5	2000	Parthenolide effectively suppressed iNOS promoter activity in a dose-dependent manner at concentrations higher than 2.	parthenolide	0-12	nitric oxide synthase 2	Homo sapiens	36-40	
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	parthenolide	238-250	nitric oxide synthase 2	Homo sapiens	105-109	
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	parthenolide	238-250	nitric oxide synthase 2	Homo sapiens	185-189