PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21992677-0 2011 Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells. parthenolide 0-12 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 30-34 21992677-11 2011 Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation. parthenolide 162-174 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 130-134 21992677-11 2011 Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation. parthenolide 162-174 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 193-197 21992677-14 2011 Parthenolide inhibited both NFkappaB and MAPK/AP-1 pathways contributing to the inhibition of IL-8 production. parthenolide 0-12 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 46-50