PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20093358-6 2010 In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. parthenolide 33-45 NLR family pyrin domain containing 3 Homo sapiens 88-93 20093358-6 2010 In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. parthenolide 33-45 NLR family pyrin domain containing 3 Homo sapiens 158-163 20093358-6 2010 In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. parthenolide 33-45 NLR family pyrin domain containing 3 Homo sapiens 158-163 20093358-7 2010 Our results thus elucidate the molecular mechanism for the therapeutic anti-inflammatory activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that target the NLRP3 inflammasome. parthenolide 101-113 NLR family pyrin domain containing 3 Homo sapiens 199-204