PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22949848-0	2012	2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution.	quinoline	28-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73	
31100281-5	2019	Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site.	quinoline	34-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65	
11863435-9	2002	Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure.	quinoline	111-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87	
11863435-9	2002	Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure.	quinoline	111-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	220-224	
32537757-6	2020	All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE.	quinoline	11-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-94	
32537757-6	2020	All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE.	quinoline	11-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-100	
32537757-6	2020	All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE.	quinoline	11-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	265-269	
28868119-5	2017	Compound 3b containing the quinoline group showed the best activity with an IC50 value of 8.80 muM against AChE.	quinoline	27-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-111	
29992880-8	2018	CONCLUSION: Tacrine-quinoline hybrids 7a exhibited the highest activity towards hBChE (IC50 = 0.97 micromol) and 7d towards hAChE (IC50 = 0.32 micromol).	quinoline	20-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-129	
26861273-5	2016	In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system.	quinoline	184-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150	
26861273-9	2016	These results are quite interesting since the triazole-quinoline system is a new structural scaffold for AChE inhibitors.	quinoline	55-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109