PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32537757-6 2020 All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE. quinoline 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 22949848-0 2012 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution. quinoline 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. quinoline 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. quinoline 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 29992880-8 2018 CONCLUSION: Tacrine-quinoline hybrids 7a exhibited the highest activity towards hBChE (IC50 = 0.97 micromol) and 7d towards hAChE (IC50 = 0.32 micromol). quinoline 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-129 28868119-5 2017 Compound 3b containing the quinoline group showed the best activity with an IC50 value of 8.80 muM against AChE. quinoline 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 26861273-5 2016 In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system. quinoline 184-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26861273-9 2016 These results are quite interesting since the triazole-quinoline system is a new structural scaffold for AChE inhibitors. quinoline 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32537757-6 2020 All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE. quinoline 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 32537757-6 2020 All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE. quinoline 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-269 31100281-5 2019 Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site. quinoline 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65