PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24111524-0	2014	Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network.	celastrol	0-9	phosphatase and tensin homolog	Homo sapiens	77-81	
24111524-15	2014	Celastrol suppresses Cd-activated Akt/mTOR pathway by elevating PTEN (phosphatase and tensin homolog).	celastrol	0-9	phosphatase and tensin homolog	Homo sapiens	64-68	
24111524-8	2014	Furthermore, pre-treatment with celastrol prevented Cd down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and activation of phosphoinositide 3"-kinase/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling in neuronal cells.	celastrol	32-41	phosphatase and tensin homolog	Homo sapiens	131-135	
24111524-9	2014	Over-expression of wild-type PTEN enhanced celastrol inhibition of Cd-activated Akt/mTOR signaling and cell death in neuronal cells.	celastrol	43-52	phosphatase and tensin homolog	Homo sapiens	29-33	
24111524-10	2014	The findings indicate that celastrol prevents Cd-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network.	celastrol	27-36	phosphatase and tensin homolog	Homo sapiens	99-103	
30989726-6	2019	In addition, the phosphorylation of PTEN was significantly up-regulated, whereas PI3K, AKT, p65, and IkappaBalpha phosphorylation was statistically decreased by celastrol (p < .05 or p < .01) and then further reversed by miR-21 overexpression (p < .05 or p < .01).	celastrol	161-170	phosphatase and tensin homolog	Homo sapiens	36-40	
30989726-8	2019	In conclusion, celastrol inhibits proliferation, migration, and invasion and inactivates PTEN/PI3K/AKT and nuclear factor kappaB signaling pathways in MKN45 cells by down-regulating miR-21.	celastrol	15-24	phosphatase and tensin homolog	Homo sapiens	89-93