PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29667734-8 2018 Taking together, we proved that celastrol could reverses PA-caused TLR4-MD2 activation-dependent insulin resistance via disrupting PA binding to MD2. celastrol 32-41 toll like receptor 4 Homo sapiens 67-71 29667734-0 2018 Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA. celastrol 0-9 toll like receptor 4 Homo sapiens 45-49 29667734-5 2018 In this study, we found evidence to support our hypothesis: celastrol could reverse PA-caused TLR4/MD2 activation-dependent insulin resistance, as determined by glucose-lowering ability, cellular glucose uptake, insulin action-related proteins and TLR4/MD2/NF-kappaB activation. celastrol 60-69 toll like receptor 4 Homo sapiens 94-98 29667734-5 2018 In this study, we found evidence to support our hypothesis: celastrol could reverse PA-caused TLR4/MD2 activation-dependent insulin resistance, as determined by glucose-lowering ability, cellular glucose uptake, insulin action-related proteins and TLR4/MD2/NF-kappaB activation. celastrol 60-69 toll like receptor 4 Homo sapiens 248-252 30015859-0 2018 Effect of celastrol on toll-like receptor 4-mediated inflammatory response in free fatty acid-induced HepG2 cells. celastrol 10-19 toll like receptor 4 Homo sapiens 23-43 30015859-6 2018 To directly elucidate whether TLR4 was the blocking target of celastrol upon FFA exposure, the cellular response to inflammation was determined upon transfection with TLR4 siRNA. celastrol 62-71 toll like receptor 4 Homo sapiens 30-34 30015859-7 2018 The results revealed that celastrol significantly reduced triglyceride accumulation in the steatotic HepG2 cells, and downregulated the expression levels of TLR4, MyD88 and phospho-NF-kappaBp65, as well as of the downstream inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. celastrol 26-35 toll like receptor 4 Homo sapiens 157-161 30015859-10 2018 These results suggest that celastrol exerts its protective effect partly via inhibiting the TLR4-mediated immune and inflammatory response in steatotic HepG2 cells. celastrol 27-36 toll like receptor 4 Homo sapiens 92-96 30220146-0 2018 [Influence of celastrol on toll-like receptor 4-mediated signaling pathway in the free fatty acids-induced HepG2 cells]. celastrol 14-23 toll like receptor 4 Homo sapiens 27-47 30220146-10 2018 Conclusion: Celastrol exerts its protective effect partly via inhibiting the TLR4-mediated signaling pathways in the steatotic HepG2 cells. celastrol 12-21 toll like receptor 4 Homo sapiens 77-81 27181127-6 2016 RESULTS: The results showed that celastrol could effectively inhibit PA-caused TLR4-dependent NF-kappaB activation in the HepG2 cells; PA also activated IRAKs, which were inhibited by celastrol. celastrol 33-42 toll like receptor 4 Homo sapiens 79-83 24157922-15 2014 These results suggest that celastrol inhibits LPS-induced angiogenesis by suppressing TLR4-triggered NF-kappaB activation. celastrol 27-36 toll like receptor 4 Homo sapiens 86-90 23861949-0 2013 Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-kappaB-mediated matrix metalloproteinase-9 expression. celastrol 0-9 toll like receptor 4 Homo sapiens 120-124 24157922-0 2014 Celastrol inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation. celastrol 0-9 toll like receptor 4 Homo sapiens 74-78 24157922-10 2014 Celastrol significantly downregulated LPS-induced TLR4 expression and inhibited LPS-induced VEGF secretion in LP-1 cells. celastrol 0-9 toll like receptor 4 Homo sapiens 50-54 23861949-6 2013 Furthermore, our results revealed that celastrol inhibited the transcriptional activity of MMP-9 by suppressing the binding activity of NF-kappaB in the MMP-9 promoter, and suppressed the TLR4/MyD88/NF-kappaB pathway. celastrol 39-48 toll like receptor 4 Homo sapiens 188-192 23861949-8 2013 In conclusion, celastrol might inhibit FLS migration and invasion induced by LPS by suppressing TLR4/NF-kappaB-mediated MMP-9 expression, providing a theoretical foundation for the clinical treatment of RA with celastrol. celastrol 15-24 toll like receptor 4 Homo sapiens 96-100 23861949-8 2013 In conclusion, celastrol might inhibit FLS migration and invasion induced by LPS by suppressing TLR4/NF-kappaB-mediated MMP-9 expression, providing a theoretical foundation for the clinical treatment of RA with celastrol. celastrol 211-220 toll like receptor 4 Homo sapiens 96-100 22949384-10 2013 Next, resistin-induced Toll-like receptor-4 (TLR-4) expression was abrogated by celastrol, indicating that TLR-4 was the resistin signaling receptor that was blocked by celastrol. celastrol 80-89 toll like receptor 4 Homo sapiens 23-43 22949384-10 2013 Next, resistin-induced Toll-like receptor-4 (TLR-4) expression was abrogated by celastrol, indicating that TLR-4 was the resistin signaling receptor that was blocked by celastrol. celastrol 80-89 toll like receptor 4 Homo sapiens 45-50 22949384-10 2013 Next, resistin-induced Toll-like receptor-4 (TLR-4) expression was abrogated by celastrol, indicating that TLR-4 was the resistin signaling receptor that was blocked by celastrol. celastrol 80-89 toll like receptor 4 Homo sapiens 107-112 22949384-10 2013 Next, resistin-induced Toll-like receptor-4 (TLR-4) expression was abrogated by celastrol, indicating that TLR-4 was the resistin signaling receptor that was blocked by celastrol. celastrol 169-178 toll like receptor 4 Homo sapiens 23-43 22949384-10 2013 Next, resistin-induced Toll-like receptor-4 (TLR-4) expression was abrogated by celastrol, indicating that TLR-4 was the resistin signaling receptor that was blocked by celastrol. celastrol 169-178 toll like receptor 4 Homo sapiens 45-50 22949384-10 2013 Next, resistin-induced Toll-like receptor-4 (TLR-4) expression was abrogated by celastrol, indicating that TLR-4 was the resistin signaling receptor that was blocked by celastrol. celastrol 169-178 toll like receptor 4 Homo sapiens 107-112 34702273-5 2021 Both in vitro and in vivo results demonstrated that celastrol inhibited the recruitment of M1 macrophage and the expression of TLR4 in corneal allografts through the TLR4/MyD88/NF-kappaB pathway, thereby significantly decreasing secretion of multiple pro-inflammatory cytokines to promote corneal allograft survival. celastrol 52-61 toll like receptor 4 Homo sapiens 127-131 34702273-5 2021 Both in vitro and in vivo results demonstrated that celastrol inhibited the recruitment of M1 macrophage and the expression of TLR4 in corneal allografts through the TLR4/MyD88/NF-kappaB pathway, thereby significantly decreasing secretion of multiple pro-inflammatory cytokines to promote corneal allograft survival. celastrol 52-61 toll like receptor 4 Homo sapiens 166-170