PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27597642-7 2016 In addition, celastrol inhibited the catalytic activities of 5-LOX (IC50=5muM) and COX-2 (IC50=20muM) in vitro; sPLA2IIA-induced edema and carrageenan-induced edema in mice; and lipopolysaccharide-stimulated production of PGE2 in human neutrophils. celastrol 13-22 arachidonate 5-lipoxygenase Mus musculus 61-66