PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30596540-8 2019 Cell viability and apoptosis assays revealed that celastrol had no apparent cytotoxic effect and it inhibited apoptosis of RPE cells at concentrations of less than 1 muM. celastrol 50-59 latexin Homo sapiens 166-169 31485297-7 2019 We found that celastrol, at higher concentrations (above 1 muM), significantly increased ROS amount in LOVO/DX cells at both cytoplasmic and mitochondrial levels. celastrol 14-23 latexin Homo sapiens 59-62 25811791-5 2015 The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively. celastrol 24-33 latexin Homo sapiens 123-126 25811791-5 2015 The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively. celastrol 24-33 latexin Homo sapiens 142-145 25811791-5 2015 The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively. celastrol 24-33 latexin Homo sapiens 142-145 25811791-5 2015 The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively. celastrol 24-33 latexin Homo sapiens 142-145 25811791-5 2015 The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively. celastrol 24-33 latexin Homo sapiens 142-145 25811791-6 2015 The data indicated that celastrol acted in different manners as an inhibitor of human cytochrome P450 isoforms, which showed that celastrol not only un-competitively inhibited the CYP1A2 and 2E1 activities, but also competitively inhibited the CYP2C19 and 2D6 activities with Ki values of 1.41, 2.29, 5.27 and 4.21 muM, respectively. celastrol 24-33 latexin Homo sapiens 315-318 25811791-6 2015 The data indicated that celastrol acted in different manners as an inhibitor of human cytochrome P450 isoforms, which showed that celastrol not only un-competitively inhibited the CYP1A2 and 2E1 activities, but also competitively inhibited the CYP2C19 and 2D6 activities with Ki values of 1.41, 2.29, 5.27 and 4.21 muM, respectively. celastrol 130-139 latexin Homo sapiens 315-318 25811791-7 2015 Celastrol was also a mixed-type inhibitor of CYP3A4, with Ki and Kis values of 2.02 and 5.49 muM, respectively. celastrol 0-9 latexin Homo sapiens 93-96 24157922-11 2014 VEGF levels decreased by 64.8, 84.4 and 92.9% after coexposure to celastrol at 0.025, 0.05 and 0.1 muM, respectively, compared to LPS alone. celastrol 66-75 latexin Homo sapiens 99-102 24157922-9 2014 A 45-74% inhibition of LPS-dependent cell invasion was achieved in the presence of 0.025-0.1 muM celastrol. celastrol 97-106 latexin Homo sapiens 93-96