PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31485297-7	2019	We found that celastrol, at higher concentrations (above 1 muM), significantly increased ROS amount in LOVO/DX cells at both cytoplasmic and mitochondrial levels.	celastrol	14-23	latexin	Homo sapiens	59-62	
30596540-8	2019	Cell viability and apoptosis assays revealed that celastrol had no apparent cytotoxic effect and it inhibited apoptosis of RPE cells at concentrations of less than 1 muM.	celastrol	50-59	latexin	Homo sapiens	166-169	
25811791-5	2015	The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively.	celastrol	24-33	latexin	Homo sapiens	123-126	
25811791-5	2015	The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively.	celastrol	24-33	latexin	Homo sapiens	142-145	
25811791-5	2015	The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively.	celastrol	24-33	latexin	Homo sapiens	142-145	
25811791-5	2015	The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively.	celastrol	24-33	latexin	Homo sapiens	142-145	
25811791-5	2015	The results showed that celastrol inhibited the five types of human cytochrome P450 isoforms, with the IC50 values of 2.65 muM (CYP3A4), 5.99 muM (CYP2C19), 6.27 muM (CYP2D6), 7.66 muM (CYP1A2) and 9.38 muM (CYP2E1), respectively.	celastrol	24-33	latexin	Homo sapiens	142-145	
25811791-6	2015	The data indicated that celastrol acted in different manners as an inhibitor of human cytochrome P450 isoforms, which showed that celastrol not only un-competitively inhibited the CYP1A2 and 2E1 activities, but also competitively inhibited the CYP2C19 and 2D6 activities with Ki values of 1.41, 2.29, 5.27 and 4.21 muM, respectively.	celastrol	24-33	latexin	Homo sapiens	315-318	
25811791-6	2015	The data indicated that celastrol acted in different manners as an inhibitor of human cytochrome P450 isoforms, which showed that celastrol not only un-competitively inhibited the CYP1A2 and 2E1 activities, but also competitively inhibited the CYP2C19 and 2D6 activities with Ki values of 1.41, 2.29, 5.27 and 4.21 muM, respectively.	celastrol	130-139	latexin	Homo sapiens	315-318	
25811791-7	2015	Celastrol was also a mixed-type inhibitor of CYP3A4, with Ki and Kis values of 2.02 and 5.49 muM, respectively.	celastrol	0-9	latexin	Homo sapiens	93-96	
24157922-11	2014	VEGF levels decreased by 64.8, 84.4 and 92.9% after coexposure to celastrol at 0.025, 0.05 and 0.1 muM, respectively, compared to LPS alone.	celastrol	66-75	latexin	Homo sapiens	99-102	
24157922-9	2014	A 45-74% inhibition of LPS-dependent cell invasion was achieved in the presence of 0.025-0.1 muM celastrol.	celastrol	97-106	latexin	Homo sapiens	93-96