PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32848589-0	2020	Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-kappaB Signaling Pathway.	celastrol	27-36	high mobility group box 1	Rattus norvegicus	95-100	
32848589-8	2020	Simultaneously, we found that mechanisms responsible for the neuroprotective effect of celastrol could be attributed to its anti-inflammatory and antioxidant actions via inhibiting HMGB1/NF-kappaB signaling pathway.	celastrol	87-96	high mobility group box 1	Rattus norvegicus	181-186	
30395883-0	2019	Celastrol ameliorates inflammatory pain and modulates HMGB1/NF-kappaB signaling pathway in dorsal root ganglion.	celastrol	0-9	high mobility group box 1	Rattus norvegicus	54-59	
30395883-3	2019	We aim to investigate whether HMGB1 in dorsal root ganglion (DRG) participates in the effect of celastrol on inflammatory pain.	celastrol	96-105	high mobility group box 1	Rattus norvegicus	30-35	
30395883-8	2019	These results showed that celastrol significantly suppressed HMGB1, NF-kappaB and IL-1beta mRNA and protein expression in DRG and alleviated CFA-evoked thermal hyperalgesia.	celastrol	26-35	high mobility group box 1	Rattus norvegicus	61-66	
30395883-10	2019	Collectively, the present study firstly provide evidences of the anti-inflammatory effect of celastrol via suppressing CFA-induced the activation of HMGB1/NF-kappaB signaling pathway in DRG, which maybe a potential therapeutic target for celastrol alleviating inflammatory pain.	celastrol	93-102	high mobility group box 1	Rattus norvegicus	149-154	
29475002-0	2018	Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway.	celastrol	0-9	high mobility group box 1	Rattus norvegicus	92-117	
29475002-2	2018	This study aimed to investigate the cardioprotective effects of celastrol pretreatment on I/R injury and to further explore whether its mechanism of action was associated with the inhibition of high mobility group box 1 protein (HMGB1) expression via the phosphoinositide 3-kinase (PI3K)/Akt pathway.	celastrol	64-73	high mobility group box 1	Rattus norvegicus	229-234	
29475002-7	2018	Additionally, celastrol downregulated HMGB1 expression and upregulated p-Akt expression in the myocardium.	celastrol	14-23	high mobility group box 1	Rattus norvegicus	38-43	
29475002-9	2018	CONCLUSION: These findings suggest that short-term pretreatment with celastrol protects against myocardial I/R injury by suppressing myocardial apoptosis, inflammatory response and oxidative stress via pI3k/Akt pathway activation and HMGB1 inhibition.	celastrol	69-78	high mobility group box 1	Rattus norvegicus	234-239	
34372857-0	2021	Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.	celastrol	0-9	high mobility group box 1	Rattus norvegicus	65-70	
34305512-0	2021	Corrigendum: Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-kappaB Signaling Pathway.	celastrol	40-49	high mobility group box 1	Rattus norvegicus	108-113	
34428765-0	2021	Celastrol Exerts Cardioprotective Effect in Rheumatoid Arthritis by Inhibiting TLR2/HMGB1 Signaling Pathway-Mediated Autophagy.	celastrol	0-9	high mobility group box 1	Rattus norvegicus	84-89	
34428765-12	2021	RA induced cell autophagy can be suppressed by Celastrol through inhibiting the activation of TLR2/HMGB1 signal pathway.	celastrol	47-56	high mobility group box 1	Rattus norvegicus	99-104	
34428765-13	2021	CONCLUSION: Celastrol can regulate TLR2/HMGB1 signal pathway to suppress autophagy and therefore exert cardioprotective effect in RA.	celastrol	12-21	high mobility group box 1	Rattus norvegicus	40-45