PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30894367-2	2019	Celastrol, a compound found in the roots of the Tripterygium wilfordii and known to reduce endoplasmic reticulum (ER) stress, has recently emerged as a promising candidate to treat obesity by improving leptin sensitivity.	celastrol	0-9	leptin	Mus musculus	202-208	
34549728-6	2021	The plant-based inhibitor of PERK, celastrol, increases leptin sensitivity, resulting in decreased food intake and body weight in a murine model of diet-induced obesity (DIO).	celastrol	35-44	leptin	Mus musculus	56-62	
34549728-7	2021	Our data extend these observations by demonstrating that celastrol-induced improvements in leptin sensitivity and energy balance were attenuated in mice with PERK deficiency in POMC neurons.	celastrol	57-66	leptin	Mus musculus	91-97	
32431112-9	2020	Hypothalamic transcriptome analysis showed a significant enrichment of the leptin signaling pathway, and we found that celastrol significantly enhanced energy expenditure, which was mediated by the leptin signaling pathway.	celastrol	119-128	leptin	Mus musculus	198-204	
31488870-1	2019	Celastrol is a leptin-sensitizing agent with profound anti-obesity effects in diet-induced obese (DIO) mice.	celastrol	0-9	leptin	Mus musculus	15-21	
31488870-2	2019	However, the genes and pathways that mediate celastrol-induced leptin sensitization have not been fully understood.	celastrol	45-54	leptin	Mus musculus	63-69	
34526895-0	2021	Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability.	celastrol	64-73	leptin	Mus musculus	34-40	
30525586-2	2018	Celastrol-administered mice at 100 mug/kg decrease food consumption and body weight via a leptin-dependent mechanism, yet its molecular targets in this pathway remain elusive.	celastrol	0-9	leptin	Mus musculus	90-96	
30525586-6	2018	By using a panel of PTPs implicated in hypothalamic leptin signaling, we show that celastrol additionally inhibited PTEN and SHP2 but had no activity toward other phosphatases of the PTP family.	celastrol	83-92	leptin	Mus musculus	52-58