PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33753246-4	2021	In reported studies, the anti-obesity effect of celastrol resulted from regulating leptin sensitivity, energy metabolism, inflammation, lipid metabolism and even gut microbiota.	celastrol	48-57	leptin	Homo sapiens	83-89	
26842874-5	2016	Notably, several food compounds, such as teasaponins, resveratrol, celastrol, caffeine, and taurine among others, are able to restore the leptin signaling in neurons by overexpressing anorexigenic peptides (proopiomelanocortin) and/or repressing orexigenic peptides (neuropeptide Y/agouti-related peptide), thus decreasing food intake.	celastrol	67-76	leptin	Homo sapiens	138-144	
30773944-9	2019	Treatment with celastrol inhibited colorectal cancer cell growth and migration, and was associated with suppression of the expression of key genes (TYMP, CDH5, THBS2, LEP, MMP9, and TNF) and proteins (IL-1b, MMP-9, PDGF, Serpin E1, and TIMP-4) involved in the angiogenesis pathway.	celastrol	15-24	leptin	Homo sapiens	167-170	
30821426-0	2019	The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.	celastrol	22-31	leptin	Homo sapiens	4-10	
30821426-4	2019	Here we demonstrate that celastrol, a natural phytochemical that was previously shown to act as a leptin sensitizer, induces weight loss in aged animals, but not in young controls.	celastrol	25-34	leptin	Homo sapiens	98-104