PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26658436-4	2015	We have shown, in vitro, that celastrol inhibits both IL-1beta and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties.	celastrol	30-39	interleukin 1 beta	Rattus norvegicus	54-62	
30395883-8	2019	These results showed that celastrol significantly suppressed HMGB1, NF-kappaB and IL-1beta mRNA and protein expression in DRG and alleviated CFA-evoked thermal hyperalgesia.	celastrol	26-35	interleukin 1 beta	Rattus norvegicus	82-90	
28458159-4	2017	Our results showed that celastrol reduced the expression of catabolic genes (MMP-3, 9, 13, ADAMTS-4, 5), oxidative stress factors (COX-2, iNOS) and pro-inflammatory factors (IL-6, TNF-a) induced by IL-1beta in nucleus pulposus cells, also phosphorylation of IkappaBalpha and p65 were attenuated by celastrol, indicating NF-kappaB pathway was inhibited by celastrol in nucleus pulposus cells.	celastrol	24-33	interleukin 1 beta	Rattus norvegicus	198-206	
23981709-7	2014	RESULTS: Celastrol significantly suppressed elevation of the renal function markers and the lipid peroxidation level, alleviated renal tubular damage, and decreased the levels of tumor necrosis factor-alpha, interleukin-1beta, and monocyte chemotactic protein-1 (MCP-1) messenger RNA in kidney caused by IR.	celastrol	9-18	interleukin 1 beta	Rattus norvegicus	208-225	
22854193-9	2012	Celastrol-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1alpha, and GRO/KC) as well as cytokines (TNF-alpha and IL-1beta) that induce them, compared to the vehicle-treated rats.	celastrol	0-9	interleukin 1 beta	Rattus norvegicus	158-166	
34510370-10	2022	Additionally, the levels of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 6, detected by ELISA in the spinal cord of the rats with NP, were significantly inhibited by celastrol.	celastrol	226-235	interleukin 1 beta	Rattus norvegicus	99-116	
19671767-5	2009	Celastrol, BMS-345541, and parthenolide abolished IL1beta and tumor necrosis factor alpha-induced IkappaB phosphorylation and prevented nuclear translocation of NF-kappaB and DNA binding.	celastrol	0-9	interleukin 1 beta	Rattus norvegicus	50-57	
18577440-7	2008	The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats.	celastrol	15-25	interleukin 1 beta	Rattus norvegicus	57-74	
18577440-7	2008	The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats.	celastrol	15-25	interleukin 1 beta	Rattus norvegicus	76-84