PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30768745-8	2019	Our results showed that celastrol could not only reduce contents of creatinine and urea nitrogen in blood but also reduce excretion of urinary protein in diabetic rats, improve renal pathological injury, and down-regulate the expression of p38MAPK and NF-kappaB p65.	celastrol	24-33	synaptotagmin 1	Rattus norvegicus	262-265	
32112120-10	2020	Moreover, celastrol decreased the IL-1beta-stimulated phosphorylation degree of IkappaBalpha and P65.	celastrol	10-19	synaptotagmin 1	Rattus norvegicus	97-100	
28189063-5	2017	Furthermore, celastrol inhibited CLP-induced elevations in hepatic mRNA expression of nuclear factor inhibitory protein kappa-B alpha (NFkappaBia), TLR-4, 5-lipoxygenase (5-LOX) and prevented NF-kappaB/p65 nuclear translocation and activation.	celastrol	13-22	synaptotagmin 1	Rattus norvegicus	202-205	
28458159-4	2017	Our results showed that celastrol reduced the expression of catabolic genes (MMP-3, 9, 13, ADAMTS-4, 5), oxidative stress factors (COX-2, iNOS) and pro-inflammatory factors (IL-6, TNF-a) induced by IL-1beta in nucleus pulposus cells, also phosphorylation of IkappaBalpha and p65 were attenuated by celastrol, indicating NF-kappaB pathway was inhibited by celastrol in nucleus pulposus cells.	celastrol	24-33	synaptotagmin 1	Rattus norvegicus	275-278	
25059279-5	2015	Furthermore, celastrol significantly suppressed cytokine- induced signaling cascades leading to nuclear factor kappa B (NF-kappaB) activation, including IkappaB-kinase (IKK) activation, IkappaB degradation, p65 phosphorylation, and p65 DNA binding activity.	celastrol	13-22	synaptotagmin 1	Rattus norvegicus	207-210	
25059279-5	2015	Furthermore, celastrol significantly suppressed cytokine- induced signaling cascades leading to nuclear factor kappa B (NF-kappaB) activation, including IkappaB-kinase (IKK) activation, IkappaB degradation, p65 phosphorylation, and p65 DNA binding activity.	celastrol	13-22	synaptotagmin 1	Rattus norvegicus	232-235	
23981709-8	2014	Moreover, celastrol prevented IR-induced expression of pro-inflammatory mediators, which was associated with suppression of nuclear translocation of NF-kappaB subunit p65.	celastrol	10-19	synaptotagmin 1	Rattus norvegicus	167-170