PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25116125-0 2014 Celastrol inhibits lung infiltration in differential syndrome animal models by reducing TNF-alpha and ICAM-1 levels while preserving differentiation in ATRA-induced acute promyelocytic leukemia cells. celastrol 0-9 intercellular adhesion molecule 1 Homo sapiens 102-108 25116125-5 2014 In ATRA-treated NB4 cells, celastrol could potently inhibit ICAM-1 elevation and partially reduce TNF-alpha and IL-1beta secretion, though treatment showed no effects on IL-8 and MCP-1 levels. celastrol 27-36 intercellular adhesion molecule 1 Homo sapiens 60-66 25116125-6 2014 Celastrol"s effect on ICAM-1 in ATRA-treated NB4 was related to reducing MEK1/ERK1 activation. celastrol 0-9 intercellular adhesion molecule 1 Homo sapiens 22-28 20599745-0 2010 Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. celastrol 0-9 intercellular adhesion molecule 1 Homo sapiens 39-45 21306773-5 2011 Here we exploit a physiological molecular interaction between intercellular adhesion molecule (ICAM)-1 and lymphocyte function associated antigen (LFA)-1 to deliver a potent anti-inflammatory drug, celastrol, specifically and comprehensively to inflamed cells. celastrol 198-207 intercellular adhesion molecule 1 Homo sapiens 62-102 21414301-8 2011 Furthermore, Nrf2 siRNA significantly reversed the inhibitory effect of celastrol on IFN-gamma-induced expression of ICAM-1 in the keratinocytes. celastrol 72-81 intercellular adhesion molecule 1 Homo sapiens 117-123 20599745-2 2010 In this study, we examined the suppressive effect of celastrol on IFN-gamma-induced expression of ICAM-1 and the molecular mechanism responsible for these activities. celastrol 53-62 intercellular adhesion molecule 1 Homo sapiens 98-104 20599745-4 2010 Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1. celastrol 125-134 intercellular adhesion molecule 1 Homo sapiens 187-193 20599745-5 2010 HO-1 knockdown using small interfering RNA (siRNA) led to reverse inhibition of IFN-gamma-induced up-regulation of ICAM-1 by celastrol. celastrol 125-134 intercellular adhesion molecule 1 Homo sapiens 115-121 20599745-6 2010 In addition, SnPP reversed suppression of IFN-gamma-induced promoter activity of ICAM-1 by celastrol. celastrol 91-100 intercellular adhesion molecule 1 Homo sapiens 81-87 20599745-8 2010 These results suggest that celastrol may exert anti-inflammatory responses by suppressing IFN-gamma-induced expression of ICAM-1 and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes. celastrol 27-36 intercellular adhesion molecule 1 Homo sapiens 122-128 28027722-4 2017 Celastrol significantly inhibited poly(I:C)-induced expression of adhesion molecules, such as ICAM-1/VCAM-1, and chemokines, such as CCL2, CXCL8, and CXCL10, in CRT-MG human astroglioma cells. celastrol 0-9 intercellular adhesion molecule 1 Homo sapiens 94-100 16769766-4 2006 In the present study, we show that in inflammatory conditions, mimicked by tumor necrosis factor alpha (TNF-alpha) stimulation, pretreatment for 6 h with tripterine at nontoxic concentrations of 20-200 nM inhibits the expression of E-selectin, vascular cell adhesion molecule (CAM)-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVEC) in a dose-dependent manner. celastrol 154-164 intercellular adhesion molecule 1 Homo sapiens 298-331 16769766-4 2006 In the present study, we show that in inflammatory conditions, mimicked by tumor necrosis factor alpha (TNF-alpha) stimulation, pretreatment for 6 h with tripterine at nontoxic concentrations of 20-200 nM inhibits the expression of E-selectin, vascular cell adhesion molecule (CAM)-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVEC) in a dose-dependent manner. celastrol 154-164 intercellular adhesion molecule 1 Homo sapiens 333-339 16769766-5 2006 Tripterine (200 nM) almost completely inhibits expression of VCAM-1 [50% inhibitory concentration (IC50) = 52 nM] and ICAM-1 (IC50 = 51 nM) and 73% of E-selectin (IC50 = 94 nM). celastrol 0-10 intercellular adhesion molecule 1 Homo sapiens 118-124 17498488-5 2007 RESULTS: ATRA caused remarkable elevation of intercellular adhesion molecule-1 (ICAM-1) in NB4 cells, which could be significantly reduced by tripterine (P<0.01). celastrol 142-152 intercellular adhesion molecule 1 Homo sapiens 45-78 17498488-5 2007 RESULTS: ATRA caused remarkable elevation of intercellular adhesion molecule-1 (ICAM-1) in NB4 cells, which could be significantly reduced by tripterine (P<0.01). celastrol 142-152 intercellular adhesion molecule 1 Homo sapiens 80-86 17498488-6 2007 The expressions of E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and ICAM-1 in HUVEC were elevated by conditioned medium from ATRA-induced NB4 (ATRA-NB4-CM) (P<0.01), and inhibited by tripterine with inhibition rates being 25.3%, 42.4% and 61.0% respectively. celastrol 196-206 intercellular adhesion molecule 1 Homo sapiens 78-84 27484716-7 2016 The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2. celastrol 30-39 intercellular adhesion molecule 1 Homo sapiens 122-155 27484716-7 2016 The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2. celastrol 30-39 intercellular adhesion molecule 1 Homo sapiens 157-163 27484716-7 2016 The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2. celastrol 30-39 intercellular adhesion molecule 1 Homo sapiens 240-246