PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26768587-8 2016 Celastrol also reduces inflammation in BLM-induced rats as evidenced by decrease in the expressions of mast cells, Tumor necrosis factor-alpha (TNF- alpha) and matrix metalloproteinases (MMPs) 2 and 9. celastrol 0-9 tumor necrosis factor Rattus norvegicus 115-142 29256892-10 2017 Moreover, treatment with 50 nM celastrol significantly downregulated mRNA and protein expression of TNF-alpha and IL-1ss. celastrol 31-40 tumor necrosis factor Rattus norvegicus 100-109 28458159-4 2017 Our results showed that celastrol reduced the expression of catabolic genes (MMP-3, 9, 13, ADAMTS-4, 5), oxidative stress factors (COX-2, iNOS) and pro-inflammatory factors (IL-6, TNF-a) induced by IL-1beta in nucleus pulposus cells, also phosphorylation of IkappaBalpha and p65 were attenuated by celastrol, indicating NF-kappaB pathway was inhibited by celastrol in nucleus pulposus cells. celastrol 24-33 tumor necrosis factor Rattus norvegicus 180-185 26768587-8 2016 Celastrol also reduces inflammation in BLM-induced rats as evidenced by decrease in the expressions of mast cells, Tumor necrosis factor-alpha (TNF- alpha) and matrix metalloproteinases (MMPs) 2 and 9. celastrol 0-9 tumor necrosis factor Rattus norvegicus 144-154 25571843-10 2015 The plasma levels of ALT, LDH, TNF-alpha, and nitric oxide metabolites increased markedly during sepsis, which significantly reduced after celastrol treatments. celastrol 139-148 tumor necrosis factor Rattus norvegicus 31-40 26658436-4 2015 We have shown, in vitro, that celastrol inhibits both IL-1beta and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties. celastrol 30-39 tumor necrosis factor Rattus norvegicus 67-70 25571843-11 2015 Celastrol attenuated iNOS, TNF-alpha, NF-kappaB phospho-p65 expression, superoxide anion production, and caspase 3 activity in the cardiovascular system, all of which were markedly elevated after LPS challenge. celastrol 0-9 tumor necrosis factor Rattus norvegicus 27-36 23981709-7 2014 RESULTS: Celastrol significantly suppressed elevation of the renal function markers and the lipid peroxidation level, alleviated renal tubular damage, and decreased the levels of tumor necrosis factor-alpha, interleukin-1beta, and monocyte chemotactic protein-1 (MCP-1) messenger RNA in kidney caused by IR. celastrol 9-18 tumor necrosis factor Rattus norvegicus 179-206 16092942-8 2005 Celastrol induced heat shock protein 70 within dopaminergic neurons and decreased tumor necrosis factor-alpha and nuclear factor kappa B immunostainings as well as astrogliosis. celastrol 0-9 tumor necrosis factor Rattus norvegicus 82-109 22854193-9 2012 Celastrol-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1alpha, and GRO/KC) as well as cytokines (TNF-alpha and IL-1beta) that induce them, compared to the vehicle-treated rats. celastrol 0-9 tumor necrosis factor Rattus norvegicus 144-153 19671767-5 2009 Celastrol, BMS-345541, and parthenolide abolished IL1beta and tumor necrosis factor alpha-induced IkappaB phosphorylation and prevented nuclear translocation of NF-kappaB and DNA binding. celastrol 0-9 tumor necrosis factor Rattus norvegicus 62-89 18577440-7 2008 The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats. celastrol 15-25 tumor necrosis factor Rattus norvegicus 139-166 18577440-7 2008 The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats. celastrol 15-25 tumor necrosis factor Rattus norvegicus 168-177 34510370-10 2022 Additionally, the levels of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 6, detected by ELISA in the spinal cord of the rats with NP, were significantly inhibited by celastrol. celastrol 226-235 tumor necrosis factor Rattus norvegicus 87-96 34510370-10 2022 Additionally, the levels of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 6, detected by ELISA in the spinal cord of the rats with NP, were significantly inhibited by celastrol. celastrol 226-235 tumor necrosis factor Rattus norvegicus 58-85 30395883-9 2019 Furthermore, celastrol obviously inhibited COX-2 protein expression and down-regulated IL-6, IL-17, TNF-alpha, MCP-1, GFAP and CD11b mRNA levels in DRG of CFA rats. celastrol 13-22 tumor necrosis factor Rattus norvegicus 100-109 34428765-10 2021 Compared with CIA model, Celastrol treatment could suppress the release of inflammatory cytokines, including TNF-alpha, IL-6, IL-1beta, as well as inhibiting the expressions of Bax, cleaved caspase3, collagen I, collagen III and alpha-SMA. celastrol 25-34 tumor necrosis factor Rattus norvegicus 109-118 32848589-6 2020 Our results indicated that celastrol dose-dependently reduced hippocampal and serum concentration of pro-inflammatory markers (TNF-alpha, IL-1beta, and IL-6) and oxidative stress marker (MDA), whereas the anti-inflammatory marker IL-10 and antioxidant markers (GSH, SOD, and CAT) were increased significantly in celastrol treated tGCI/R rats. celastrol 27-36 tumor necrosis factor Rattus norvegicus 127-136 32402948-7 2020 The increased levels of inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and interferon (IFN)-gamma, were abolished by celastrol treatment. celastrol 167-176 tumor necrosis factor Rattus norvegicus 56-89 32402948-11 2020 Nox4 overexpression reversed the abolishing effects of celastrol on the increases of TNF-alpha, IL-1beta, IL-6, and IFN-gamma levels in the serum of CIA rats. celastrol 55-64 tumor necrosis factor Rattus norvegicus 85-94