PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18202019-8 2008 However, celastrol (1-5 micromol/L) induced Hsp90 client protein degradation (Cdk4 and Akt) by 70% to 80% and increased Hsp70 expression by 12-fold. celastrol 9-18 thymoma viral proto-oncogene 1 Mus musculus 87-90 25858875-10 2015 The Western blotting analysis of the PI3K/Akt/mTOR pathway and autophagy showed that celastrol treatment up-regulated the autophagy of colon tissue by suppressing the PI3K/Akt/mTOR signaling pathway. celastrol 85-94 thymoma viral proto-oncogene 1 Mus musculus 42-45 25858875-10 2015 The Western blotting analysis of the PI3K/Akt/mTOR pathway and autophagy showed that celastrol treatment up-regulated the autophagy of colon tissue by suppressing the PI3K/Akt/mTOR signaling pathway. celastrol 85-94 thymoma viral proto-oncogene 1 Mus musculus 172-175 25858875-11 2015 CONCLUSIONS: Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy by suppressing the PI3K/Akt/mTOR signaling pathway. celastrol 13-22 thymoma viral proto-oncogene 1 Mus musculus 139-142 23065091-0 2012 Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. celastrol 0-9 thymoma viral proto-oncogene 1 Mus musculus 160-163 23065091-8 2012 Moreover, celastrol inhibited the activation of PI3K/AKT/mTOR signaling cascade in B16 cells. celastrol 10-19 thymoma viral proto-oncogene 1 Mus musculus 53-56 23065091-9 2012 Our data reveal that celastrol inhibits growth and induces apoptosis in melanoma cells via the activation of ROS-mediated caspase-dependent and -independent pathways and the suppression of PI3K/AKT signaling. celastrol 21-30 thymoma viral proto-oncogene 1 Mus musculus 194-197 26402060-5 2015 Tripterine restored integrin-linked kinase (ILK) levels downregulated by ox-LDL in EPCs, suggesting the involvement of the ILK/Akt pathway. celastrol 0-10 thymoma viral proto-oncogene 1 Mus musculus 127-130 35359864-0 2022 Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments. celastrol 0-9 thymoma viral proto-oncogene 1 Mus musculus 59-62 34337076-10 2021 However, in an MCF-7-implanted nude mouse model, it was possible to detect significantly decreased tumour volumes and tumour weights and decreased p-Akt and p-mTOR protein expression in the celastrol+tamoxifen group. celastrol 190-199 thymoma viral proto-oncogene 1 Mus musculus 149-152 35419676-0 2022 Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells. celastrol 0-9 thymoma viral proto-oncogene 1 Mus musculus 50-53 35419676-2 2022 Previous studies have shown that celastrol has antitumor effects on a variety of tumor cells via the AKT/mTOR signaling. celastrol 33-42 thymoma viral proto-oncogene 1 Mus musculus 101-104 35419676-12 2022 CONCLUSION: Celastrol exerts potent antitumor effects on ACTH-secreting adenoma by downregulating the AKT/mTOR signaling in vitro and in vivo. celastrol 12-21 thymoma viral proto-oncogene 1 Mus musculus 102-105 35359864-7 2022 Among them, PIK3R1, SRC, MAPK1, AKT1, and HRAS were selected as the top 5 closely related targets to celastrol. celastrol 101-110 thymoma viral proto-oncogene 1 Mus musculus 32-36 35359864-9 2022 Subsequently, celastrol administration significantly ameliorated hepatitis and liver fibrosis by reducing AKT1 and PI3K phosphorylation in both acute liver injury and chronic models of autoimmune hepatitis. celastrol 14-23 thymoma viral proto-oncogene 1 Mus musculus 106-110 35359864-10 2022 Conclusion: In summary, celastrol significantly attenuates autoimmune hepatitis by suppressing the PI3K/AKT signaling pathway, confirmed by validated animal models. celastrol 24-33 thymoma viral proto-oncogene 1 Mus musculus 104-107 31904241-0 2020 Celastrol-loaded galactosylated liposomes effectively inhibit AKT/c-Met-triggered rapid hepatocarcinogenesis in mice. celastrol 0-9 thymoma viral proto-oncogene 1 Mus musculus 62-65 33387968-10 2021 Celastrol increased antioxidant capacity, inhibited cell apoptosis, and improved mitochondrial function, effectively improving learning and memory by downregulating AK005401 and MAP3K12 and activating PI3K/Akt. celastrol 0-9 thymoma viral proto-oncogene 1 Mus musculus 206-209 32815304-6 2020 Through suppressing the phosphorylation of upstream EGFR and downstream Akt in the EGFR pathway by gefitinib and celastrol, respectively, the nanodrug exhibits high inhibition efficacy against orthotopic NSCLC in mouse models. celastrol 113-122 thymoma viral proto-oncogene 1 Mus musculus 72-75 32116702-8 2020 Hypoxia inducible factor (HIF)-1alpha, phosphorylated PI3K, Akt, and mTOR were also downregulated by treatment with celastrol. celastrol 116-125 thymoma viral proto-oncogene 1 Mus musculus 60-63 30742994-7 2019 More importantly, in addition to these direct anti-obesity activities, celastrol augmented the PGC-1alpha and GLUT4 expression in adipocytes and skeletal muscles to increase glucose uptake through AKT and P38 MAPK activation. celastrol 71-80 thymoma viral proto-oncogene 1 Mus musculus 197-200 31957323-0 2020 Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway. celastrol 22-31 thymoma viral proto-oncogene 1 Mus musculus 124-127 31957323-8 2020 To further find the mechanism involved in the celastrol-induced biological functions, LY204002, a PI3K/Akt signaling inhibitor, and an Akt-1 overexpression plasmid were employed to find whether PI3K/Akt pathway was involved in the celastrol-induced CCA cell inhibition. celastrol 46-55 thymoma viral proto-oncogene 1 Mus musculus 103-106 31957323-8 2020 To further find the mechanism involved in the celastrol-induced biological functions, LY204002, a PI3K/Akt signaling inhibitor, and an Akt-1 overexpression plasmid were employed to find whether PI3K/Akt pathway was involved in the celastrol-induced CCA cell inhibition. celastrol 46-55 thymoma viral proto-oncogene 1 Mus musculus 135-140 31957323-8 2020 To further find the mechanism involved in the celastrol-induced biological functions, LY204002, a PI3K/Akt signaling inhibitor, and an Akt-1 overexpression plasmid were employed to find whether PI3K/Akt pathway was involved in the celastrol-induced CCA cell inhibition. celastrol 46-55 thymoma viral proto-oncogene 1 Mus musculus 135-138 31957323-9 2020 Additionally, short interfering RNA (siRNA) was also used to investigate the mechanism involved in the celastrol-induced PI3K/Akt signaling inhibition. celastrol 103-112 thymoma viral proto-oncogene 1 Mus musculus 126-129 31957323-13 2020 Further mechanistic study identified that celastrol regulated the PI3K/Akt signaling pathway, and the antitumor efficacy was likely due to the upregulation of PTEN, a negative regulator of PI3K/Akt. celastrol 42-51 thymoma viral proto-oncogene 1 Mus musculus 71-74 31957323-13 2020 Further mechanistic study identified that celastrol regulated the PI3K/Akt signaling pathway, and the antitumor efficacy was likely due to the upregulation of PTEN, a negative regulator of PI3K/Akt. celastrol 42-51 thymoma viral proto-oncogene 1 Mus musculus 194-197 31957323-14 2020 Blockage of PTEN abolished the celastrol-induced PI3K/Akt signaling inhibition. celastrol 31-40 thymoma viral proto-oncogene 1 Mus musculus 54-57 31957323-16 2020 CONCLUSIONS: Overall, our study elucidated a mechanistic framework for the anti-CCA effects of celastrol via PTEN/PI3K/Akt pathway. celastrol 95-104 thymoma viral proto-oncogene 1 Mus musculus 119-122 29270590-8 2017 Celastrol quickly induced phosphorylation of ERK1/2 and Akt within 30 min and 1 h respectively in SOD1G93A transfected NSC34 cells. celastrol 0-9 thymoma viral proto-oncogene 1 Mus musculus 56-59 30791741-12 2019 Furthermore, tripterine activated PI3K/AKT pathway and deactivated NF-kappaB pathway. celastrol 13-23 thymoma viral proto-oncogene 1 Mus musculus 39-42 30791741-14 2019 This study revealed that tripterine protected ATDC5 cells against LPS-induced cell damage possibly via up-regulation of miR-223 and modulation of NF-kappaB and PI3K/AKT pathways. celastrol 25-35 thymoma viral proto-oncogene 1 Mus musculus 165-168 29270590-9 2017 Pharmacological inhibitors of MEK (PD98059, 10 mumol/L) or Akt (MK2206, 10 mumol/L) could reverse the phosphorylation of ERK1/2 and Akt, and abolish up-regulation of GCLC and GST induced by celastrol at mRNA levels. celastrol 190-199 thymoma viral proto-oncogene 1 Mus musculus 59-62 29270590-10 2017 Taken together, we conclude that celastrol exerts a beneficial antioxidant effect in SOD1G93ANSC34 cells, which might be dependent on MEK/ERK and PI3K/Akt signaling pathway activation. celastrol 33-42 thymoma viral proto-oncogene 1 Mus musculus 151-154 31152143-9 2019 RESULTS Sorafenib treatment induced the compensatory activation of the AKT pathway and autocrine VEGF in hepatoma cells, which could be reversed by celastrol. celastrol 148-157 thymoma viral proto-oncogene 1 Mus musculus 71-74 31152143-11 2019 CONCLUSIONS Celastrol enhances the antitumor activity of sorafenib in HCC tumor cells by suppressing the AKT pathway and VEGF autocrine system. celastrol 12-21 thymoma viral proto-oncogene 1 Mus musculus 105-108 27823626-9 2016 Further mechanistic studies revealed that celastrol induced the expression of occludin and ZO-1) via activating MAPKs and PI3K/Akt/mTOR pathway. celastrol 42-51 thymoma viral proto-oncogene 1 Mus musculus 127-130