PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32470352-0 2020 Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 67-73 29394529-13 2018 Celastrol reverts these cellular changes in rat lungs, and it was found that celastrol regulates EMT through the inhibition of heat shock protein 90 (HSP 90). celastrol 77-86 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 127-148 29394529-13 2018 Celastrol reverts these cellular changes in rat lungs, and it was found that celastrol regulates EMT through the inhibition of heat shock protein 90 (HSP 90). celastrol 77-86 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 150-156 19356729-10 2009 Celastrol exerted a negative effect on FcepsilonRIbeta signaling by inhibiting the interaction between heat shock protein 90 (hsp90) and proteins, such as, FcepsilonRIbeta, Akt and PKCalpha. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 103-124 19356729-10 2009 Celastrol exerted a negative effect on FcepsilonRIbeta signaling by inhibiting the interaction between heat shock protein 90 (hsp90) and proteins, such as, FcepsilonRIbeta, Akt and PKCalpha. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 126-131 30986447-0 2019 Celastrol-type HSP90 modulators allow for potent cardioprotective effects. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 15-20 30986447-3 2019 We have previously shown that celastrol, an HSP90 modulator, achieves cardioprotection through activation of cytoprotective HSP"s and heme-oxygenase-1 (HO-1). celastrol 30-39 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 44-49 30986447-8 2019 KEY FINDINGS: From a variety of HSP90 modulator chemotypes, the celastrol family was most efficient in inducing cytoprotective HSP70 and HO-1 protein overexpression and cell survival in vitro. celastrol 64-73 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 32-37 30986447-11 2019 SIGNIFICANCE: Celastrol backbone is essential for cardioprotection through HSP90 activity modulation. celastrol 14-23 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 75-80