PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23988648-0 2013 miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells. celastrol 24-33 microRNA 224 Homo sapiens 0-7 23988648-8 2013 Finally, we evaluated the effect of miR-224 on celastrol-induced anti-tumor activity using miR-224 precursor. celastrol 47-56 microRNA 224 Homo sapiens 36-43 23988648-11 2013 Besides, celastrol efficiently decreased the expression of miR-224 and protein expression of MMP-2 and MMP-9. celastrol 9-18 microRNA 224 Homo sapiens 59-66 23988648-12 2013 ChIP-qPCR showed that p65/NF-kappaB binding to the miR-224 promoter sharply decreased after exposure to celastrol in time-dependent manner. celastrol 104-113 microRNA 224 Homo sapiens 51-58 23988648-14 2013 Most importantly, miR-224 precursor can reverse the effect of celastrol on impairment of migration and invasion in HepG2 and Huh7 cells. celastrol 62-71 microRNA 224 Homo sapiens 18-25 23988648-15 2013 CONCLUSION: Celastrol treatment inhibits migration and invasion of HCC cell and that the effect is partly due to NF-kappaB regulating miR-224 expression. celastrol 12-21 microRNA 224 Homo sapiens 134-141