PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24589236-0	2014	Peptide deformylase inhibitor actinonin reduces celastrol"s HSP70 induction while synergizing proliferation inhibition in tumor cells.	celastrol	48-57	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65	
32222543-7	2020	The increase in enzymatic activity with celastrol correlated with an increase in the transcriptional and proteome levels of the heat shock proteins Hsp90 and Hsp70.	celastrol	40-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	158-163	
32222543-8	2020	The use of specific Hsp70 or Hsp90 inhibitors showed the positive effect of celastrol on PMM2 stability and activity to occur through Hsp90-driven modulation of the proteostasis network.	celastrol	76-85	heat shock protein family A (Hsp70) member 4	Homo sapiens	20-25	
29274099-0	2018	Effects of celastrol on Tau hyperphosphorylation and expression of HSF-1 and HSP70 in SH-SY5Y neuroblastoma cells induced by amyloid-beta peptides.	celastrol	11-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	77-82	
26447544-6	2015	Additionally, the celastrol-induced expression of HSP70 and HSP27 was abrogated by triptolide.	celastrol	18-27	heat shock protein family A (Hsp70) member 4	Homo sapiens	50-55	
24589236-1	2014	BACKGROUND: Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects.	celastrol	12-21	heat shock protein family A (Hsp70) member 4	Homo sapiens	115-120	
24589236-2	2014	Concurrent use of siRNA to increase celastrol"s anti-tumor effects through HSP70 interference has been reported, but because siRNA technology is difficult to clinically apply, an alternative way to curb unwanted HSP70 elevation caused by celastrol treatment is worth exploring.	celastrol	36-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	75-80	
24589236-2	2014	Concurrent use of siRNA to increase celastrol"s anti-tumor effects through HSP70 interference has been reported, but because siRNA technology is difficult to clinically apply, an alternative way to curb unwanted HSP70 elevation caused by celastrol treatment is worth exploring.	celastrol	238-247	heat shock protein family A (Hsp70) member 4	Homo sapiens	212-217	
24589236-4	2014	RESULTS: The first strategy was unsuccessful since celastrol treatment increased HSP70 in all 7 of the cancer cell types tested, this result related to HSF1 activation.	celastrol	51-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	81-86	
24589236-6	2014	The second strategy revealed that modification of celastrol"s carboxyl group abolished its ability to elevate HSP70, but also abolished celastrol"s tumor inhibition effects.	celastrol	50-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	110-115	
24589236-7	2014	In the third strategy, 11 inhibitors for 10 signaling proteins reportedly related to celastrol action were tested, and five of these could reduce celastrol-caused HSP70 elevation.	celastrol	146-155	heat shock protein family A (Hsp70) member 4	Homo sapiens	163-168	
24589236-9	2014	CONCLUSIONS: Concurrent use of the chemical agent actinonin could reduce celastrol"s HSP70 elevation and also enhance proliferation inhibition by celastrol.	celastrol	73-82	heat shock protein family A (Hsp70) member 4	Homo sapiens	85-90	
24685625-10	2014	HSP-70 siRNA abolished celastrol mediated cytoprotection.	celastrol	23-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-6	
24351928-4	2014	Celastrol interfered with the establishment of the heat-shock protein 90/Hsp90 cochaperone Cdc37/Hsp90-Hsp70-organizing protein chaperone complex with mutant GCase and reduced heat-shock protein 90-associated protein degradation.	celastrol	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	103-108	
24685625-9	2014	Western blot and immunofluorescence analysis showed that exposure to celastrol increased HSP-70 and Bcl-2 expression but decreased NFkappaB activity, phosphorylated glycogen synthase kinase-3beta (GSK-3beta) at tyrosine 216 and cyclooxygenase-2 (COX-2) expression, Abeta accumulation together with a reduction of superoxide and hydrogen peroxide generation.	celastrol	69-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	89-95	
24685625-11	2014	CONCLUSION: This study demonstrates that celastrol reduced both LPS-induced cell death and Abeta production in vitro through increasing HSP-70 and Bcl-2 expression and reducing NFkappaB, COX-2, and GSK-3beta expression and oxidative stress.	celastrol	41-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	136-142	
23810294-0	2013	Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways.	celastrol	62-71	heat shock protein family A (Hsp70) member 4	Homo sapiens	47-52	
23583203-6	2013	The results showed that silencing of Hsp70 by chitosan-TPP-Hsp70 siRNA treatment significantly reduced cell viability, and enhanced antiproliferative effects of celastrol in leukemia and glioblastoma cells.	celastrol	161-170	heat shock protein family A (Hsp70) member 4	Homo sapiens	37-42	
23583203-6	2013	The results showed that silencing of Hsp70 by chitosan-TPP-Hsp70 siRNA treatment significantly reduced cell viability, and enhanced antiproliferative effects of celastrol in leukemia and glioblastoma cells.	celastrol	161-170	heat shock protein family A (Hsp70) member 4	Homo sapiens	59-64	
22865541-8	2013	Here, we demonstrate that celastrol, but not classical heat shock treatment, is effective in inducing a set of neuroprotective Hsps in cultures derived from cerebral cortices, including Hsp70, Hsp27 and Hsp32.	celastrol	26-35	heat shock protein family A (Hsp70) member 4	Homo sapiens	186-191	
21683142-0	2011	Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells.	celastrol	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	63-68	
21683142-8	2011	In addition, inhibition of NF-kappaB RelA/p65 activity by celastrol was attenuated when Hsp70 response was silenced by siRNA.	celastrol	58-67	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93	
21683142-10	2011	Our findings reveal that celastrol is a novel plant compound which suppresses innate immunity response in human retinal pigment epithelial cells via NF-kappaB and Hsp70 regulation, and that Hsp70 is a critical regulator of NF-kappaB.	celastrol	25-34	heat shock protein family A (Hsp70) member 4	Homo sapiens	163-168	
21683142-10	2011	Our findings reveal that celastrol is a novel plant compound which suppresses innate immunity response in human retinal pigment epithelial cells via NF-kappaB and Hsp70 regulation, and that Hsp70 is a critical regulator of NF-kappaB.	celastrol	25-34	heat shock protein family A (Hsp70) member 4	Homo sapiens	190-195	
20957029-6	2010	Heat stress- and other HSP inducer (CdCl(2), celastrol, MG132)-induced HSP70 expression could be inhibited by AICAR, an AMPK specific activator.	celastrol	45-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	71-76