PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27501757-0 2016 Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells. celastrol 81-90 microRNA 17 Homo sapiens 18-24 27501757-3 2016 In the present study, we demonstrate that the miR-17-92a cluster plays a negative role in celastrol induced-autophagy. celastrol 90-99 microRNA 17 Homo sapiens 46-52 27501757-6 2016 Celastrol induced autophagy was inhibited by miR-20a or miR-17, while the inhibitory effects were rescued in the presence of pcDNA-ATG7 lacking 3" UTR, demonstrating that these two members target ATG7 to inhibit celastrol-induced autophagy. celastrol 0-9 microRNA 17 Homo sapiens 56-62 27501757-11 2016 In summary, our results demonstrate that celastrol downregulates AR and its target miR-17-92a, leading to autophagy induction in prostate cancer cells. celastrol 41-50 microRNA 17 Homo sapiens 83-89