PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28673005-8 2017 At the molecular level, celastrol blocked the canonical NF-kappaB pathway by inhibiting IkappaBalpha phosphorylation, and preventing IkappaBalpha degradation and p65 accumulation. celastrol 24-33 RELA proto-oncogene, NF-kB subunit Homo sapiens 162-165 30989726-6 2019 In addition, the phosphorylation of PTEN was significantly up-regulated, whereas PI3K, AKT, p65, and IkappaBalpha phosphorylation was statistically decreased by celastrol (p < .05 or p < .01) and then further reversed by miR-21 overexpression (p < .05 or p < .01). celastrol 161-170 RELA proto-oncogene, NF-kB subunit Homo sapiens 92-95 30596540-9 2019 Mechanistically, RPE cells that were pretreated with celastrol exhibited a substantial decrease in phosphorylation of the NF-kappaB pathway regulators, IKKalpha/beta and IkappaBalpha, and subsequently inactivated P65, suggesting that celastrol ameliorates LPS-induced inflammation by suppressing the NF-kappaB signaling pathway. celastrol 53-62 RELA proto-oncogene, NF-kB subunit Homo sapiens 213-216 34732120-9 2022 Mechanistic protein expression revealed that celastrol suppressed the expression of COX-2 by inhibiting the phosphorylation of NF-kappaB p65 and subsequently leading to cytoplasmic retention of p65 protein, thereby inhibiting its nuclear translocation and transcription activities. celastrol 45-54 RELA proto-oncogene, NF-kB subunit Homo sapiens 127-140 34732120-9 2022 Mechanistic protein expression revealed that celastrol suppressed the expression of COX-2 by inhibiting the phosphorylation of NF-kappaB p65 and subsequently leading to cytoplasmic retention of p65 protein, thereby inhibiting its nuclear translocation and transcription activities. celastrol 45-54 RELA proto-oncogene, NF-kB subunit Homo sapiens 194-197 30389635-9 2019 We report that celastrol particularly suppressed Pin1 expression, thereby inhibiting Akt, STAT3, P38, JNK, P65, and IL-6 expression. celastrol 15-24 RELA proto-oncogene, NF-kB subunit Homo sapiens 107-110 24157922-13 2014 Protein levels of NF-kappaB p65, IKKalpha and IkappaB-alpha decreased in a dose-dependent manner after coexposure to celastrol. celastrol 117-126 RELA proto-oncogene, NF-kB subunit Homo sapiens 28-31 24664372-8 2014 Immunoblot assays revealed that celastrol treatment downregulated the expressions of IKKalpha, p50 and p65, supporting the 5"-deletion transient gene expression assay result that celastrol blocked IL-6 expression through the NF-kappaB pathway in PC-3 cells. celastrol 32-41 RELA proto-oncogene, NF-kB subunit Homo sapiens 103-106 24664372-8 2014 Immunoblot assays revealed that celastrol treatment downregulated the expressions of IKKalpha, p50 and p65, supporting the 5"-deletion transient gene expression assay result that celastrol blocked IL-6 expression through the NF-kappaB pathway in PC-3 cells. celastrol 179-188 RELA proto-oncogene, NF-kB subunit Homo sapiens 103-106 24755677-9 2014 Celastrol effectively blocked the nuclear translocation of the p65 subunit and induced human multiple myeloma cell cycle arrest and apoptosis by p27 upregulation and NF-kB modulation. celastrol 0-9 RELA proto-oncogene, NF-kB subunit Homo sapiens 63-66 24157922-14 2014 Celastrol also blocked nuclear translocation of the p65 subunit. celastrol 0-9 RELA proto-oncogene, NF-kB subunit Homo sapiens 52-55 22641218-9 2013 Celastrol, a TAK1 inhibitor and anti-inflammatory compound used in traditional Chinese medicine, also decreased TGF-beta1-induced phosphorylation of TAK1 and RELA, and suppressed basal, TGF-beta1- and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB reporter gene activity. celastrol 0-9 RELA proto-oncogene, NF-kB subunit Homo sapiens 158-162 23706078-7 2013 Celastrol also reduced IkappaB phosphorylation, nuclear P65 protein levels and NF-kappaB activity. celastrol 0-9 RELA proto-oncogene, NF-kB subunit Homo sapiens 56-59 21506956-7 2011 These effects of celastrol were mediated through suppression of constitutively active NF-kappaB induced by inhibition of IkappaBalpha kinase activation; and the phosphorylation of IkappaBalpha and of p65. celastrol 17-26 RELA proto-oncogene, NF-kB subunit Homo sapiens 200-203 23988648-12 2013 ChIP-qPCR showed that p65/NF-kappaB binding to the miR-224 promoter sharply decreased after exposure to celastrol in time-dependent manner. celastrol 104-113 RELA proto-oncogene, NF-kB subunit Homo sapiens 22-25 21683142-8 2011 In addition, inhibition of NF-kappaB RelA/p65 activity by celastrol was attenuated when Hsp70 response was silenced by siRNA. celastrol 58-67 RELA proto-oncogene, NF-kB subunit Homo sapiens 42-45 21170316-10 2010 In addition, celastrol rapidly blocked cytosolic IkappaBalpha degradation and nuclear translocation of RelA. celastrol 13-22 RELA proto-oncogene, NF-kB subunit Homo sapiens 103-107