PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32222543-6	2020	Celastrol treatment led to a significant increase in mutant PMM2 protein concentration and activity, while MG132 had a small effect on protein concentration only.	celastrol	0-9	phosphomannomutase 2	Homo sapiens	60-64	
32222543-8	2020	The use of specific Hsp70 or Hsp90 inhibitors showed the positive effect of celastrol on PMM2 stability and activity to occur through Hsp90-driven modulation of the proteostasis network.	celastrol	76-85	phosphomannomutase 2	Homo sapiens	89-93	
32222543-9	2020	The synergistic effect of celastrol and a previously described pharmacological chaperone was also examined, and a mutation-dependent synergistic effect on PMM2 activity was noted.	celastrol	26-35	phosphomannomutase 2	Homo sapiens	155-159