PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32222543-6 2020 Celastrol treatment led to a significant increase in mutant PMM2 protein concentration and activity, while MG132 had a small effect on protein concentration only. celastrol 0-9 phosphomannomutase 2 Homo sapiens 60-64 32222543-8 2020 The use of specific Hsp70 or Hsp90 inhibitors showed the positive effect of celastrol on PMM2 stability and activity to occur through Hsp90-driven modulation of the proteostasis network. celastrol 76-85 phosphomannomutase 2 Homo sapiens 89-93 32222543-9 2020 The synergistic effect of celastrol and a previously described pharmacological chaperone was also examined, and a mutation-dependent synergistic effect on PMM2 activity was noted. celastrol 26-35 phosphomannomutase 2 Homo sapiens 155-159