PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31989218-8 2020 In contrast, in the celastrol and celastrol + metformin groups, the apoptotic potential was amplified, as revealed by the increase in the caspase-9 and caspase-3 levels and Bax:BCL-2 ratio. celastrol 20-29 BCL2-associated X protein Mus musculus 173-176 31989218-8 2020 In contrast, in the celastrol and celastrol + metformin groups, the apoptotic potential was amplified, as revealed by the increase in the caspase-9 and caspase-3 levels and Bax:BCL-2 ratio. celastrol 34-43 BCL2-associated X protein Mus musculus 173-176 23065091-6 2012 Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF. celastrol 75-84 BCL2-associated X protein Mus musculus 224-227 23065091-6 2012 Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF. celastrol 142-151 BCL2-associated X protein Mus musculus 224-227