PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29434967-6	2018	Celastrol may also decrease the phosphorylation levels of signal transducer and activator of transcription 3 (STAT3) and the B cell lymphoma-2 (Bcl-2)/Bcl-2 associated C protein (Bax) ratio.	celastrol	0-9	signal transducer and activator of transcription 3	Homo sapiens	58-108	
35113665-0	2022	Correction to: Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3.	celastrol	15-24	signal transducer and activator of transcription 3	Homo sapiens	91-96	
30389635-9	2019	We report that celastrol particularly suppressed Pin1 expression, thereby inhibiting Akt, STAT3, P38, JNK, P65, and IL-6 expression.	celastrol	15-24	signal transducer and activator of transcription 3	Homo sapiens	90-95	
33999692-10	2021	Also, celastrol treatment reduced rIL-23-induced phosphorylation of STAT3 in PBMCs isolated from SO patients.	celastrol	6-15	signal transducer and activator of transcription 3	Homo sapiens	68-73	
29434967-6	2018	Celastrol may also decrease the phosphorylation levels of signal transducer and activator of transcription 3 (STAT3) and the B cell lymphoma-2 (Bcl-2)/Bcl-2 associated C protein (Bax) ratio.	celastrol	0-9	signal transducer and activator of transcription 3	Homo sapiens	110-115	
22369852-5	2012	We observed that celastrol inhibited both constitutive and inducible STAT3 activation, and the suppression was mediated through the inhibition of activation of upstream kinases c-Src, as well as Janus-activated kinase-1 and -2.	celastrol	17-26	signal transducer and activator of transcription 3	Homo sapiens	69-74	
27144550-6	2016	In addition, we found that celastrol downregulated the AML1-ETO fusion protein, therefore downregulating C-KIT kinases and inhibiting AKT, STAT3 and Erk1/2.	celastrol	27-36	signal transducer and activator of transcription 3	Homo sapiens	139-144	
22369852-0	2012	Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.	celastrol	0-9	signal transducer and activator of transcription 3	Homo sapiens	110-115	
22369852-6	2012	Vanadate treatment reversed the celastrol-induced modulation of STAT3, suggesting the involvement of a tyrosine phosphatase.	celastrol	32-41	signal transducer and activator of transcription 3	Homo sapiens	64-69	
22369852-7	2012	The inhibition of STAT3 activation by celastrol led to the suppression of various gene products involved in proliferation, survival, and angiogenesis.	celastrol	38-47	signal transducer and activator of transcription 3	Homo sapiens	18-23	
22369852-9	2012	Finally, when administered intraperitoneally, celastrol inhibited STAT3 activation in tumor tissues and the growth of human HCC xenograft tumors in athymic nu/nu mice without any side effects.	celastrol	46-55	signal transducer and activator of transcription 3	Homo sapiens	66-71	
22369852-10	2012	Overall, our results suggest for the first time that celastrol exerts its antiproliferative and proapoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo.	celastrol	53-62	signal transducer and activator of transcription 3	Homo sapiens	140-145	
21506956-0	2011	Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-kappaB and STAT3 regulated gene products in multiple myeloma cells.	celastrol	0-9	signal transducer and activator of transcription 3	Homo sapiens	105-110	
21506956-2	2011	Thus, in the present study, we investigated whether celastrol could suppress the proliferation and induce chemosensitization of MM cells by interfering with NF-kappaB and STAT3 activation pathways.	celastrol	52-61	signal transducer and activator of transcription 3	Homo sapiens	171-176	
21506956-8	2011	Celastrol also inhibited both the constitutive and IL6-induced activation of STAT3, which induced apoptosis as indicated by an increase in the accumulation of cells in the sub-G1 phase, an increase in the expression of pro-apoptotic proteins and activation of caspase-3.	celastrol	0-9	signal transducer and activator of transcription 3	Homo sapiens	77-82