PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33930802-0	2021	Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1alpha pathway.	celastrol	27-36	hypoxia inducible factor 1, alpha subunit	Mus musculus	93-103	
35035665-0	2022	Celastrol Protects against Cerebral Ischemia/Reperfusion Injury in Mice by Inhibiting Glycolysis through Targeting HIF-1alpha/PDK1 Axis.	celastrol	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	115-125	
35035665-11	2022	Moreover, celastrol inhibited the I/R-induced upregulation of HIF-1alpha and PDK1.	celastrol	10-19	hypoxia inducible factor 1, alpha subunit	Mus musculus	62-72	
35035665-12	2022	Overexpression of HIF-1alpha by DMOG reversed the protective effect of celastrol on cerebral I/R injury and blocked celastrol-induced suppression of glycolysis.	celastrol	71-80	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-28	
35035665-12	2022	Overexpression of HIF-1alpha by DMOG reversed the protective effect of celastrol on cerebral I/R injury and blocked celastrol-induced suppression of glycolysis.	celastrol	116-125	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-28	
35035665-14	2022	Taken together, these results suggested that celastrol protected against cerebral I/R injury through inhibiting glycolysis via the HIF-1alpha/PDK1 axis.	celastrol	45-54	hypoxia inducible factor 1, alpha subunit	Mus musculus	131-141	
33930802-1	2021	Four series of hypoxia-inducible factor-1 alpha (HIF-1alpha) functioning derivatives stemming from modifications to the C-29 carboxyl group of celastrol were designed and synthesized, and their anticancer activities were evaluated.	celastrol	143-152	hypoxia inducible factor 1, alpha subunit	Mus musculus	15-47	
33930802-1	2021	Four series of hypoxia-inducible factor-1 alpha (HIF-1alpha) functioning derivatives stemming from modifications to the C-29 carboxyl group of celastrol were designed and synthesized, and their anticancer activities were evaluated.	celastrol	143-152	hypoxia inducible factor 1, alpha subunit	Mus musculus	49-59