PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34600334-5	2021	Whole-genome deep sequencing analysis revealed that Nrf2, NLRP3 and caspase-1 in SNc may be associated with the neuroprotective actions of celastrol in PD.	celastrol	139-148	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56	
32277035-8	2020	NRF2 is a celastrol target expressed in the habenula (HB), known to play a critical role in the pathophysiology of depression.	celastrol	10-19	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4	
28935193-11	2017	JNK mitogen-activated protein kinase and nuclear factor erythroid 2-related factor 2 (Nrf2) were confirmed to be involved in the inductive effect of celastrol on HO-1 expression.	celastrol	149-158	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90	
28935193-0	2017	Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells.	celastrol	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103	
31032752-0	2019	Celastrol Protects RPE Cells from Oxidative Stress-Induced Cell Death via Activation of Nrf2 Signaling Pathway.	celastrol	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92	
31032752-11	2019	Treatment with celastrol enhanced the expression of transcription factor Nrf2 and its targets, GCLM and HO-1.	celastrol	15-24	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77	
31032752-12	2019	Knockdown of Nrf2 expression by shRNA partially abolished the protective effects of celastrol.	celastrol	84-93	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17	
31032752-15	2019	CONCLUSION: This study provides evidence that treatment of RPE cells with celastrol shows potent protective effects against oxidative insults via activation of Nrf2 signaling pathway and upregulation of GCLM expression.	celastrol	74-83	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164	
21414301-0	2011	Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells.	celastrol	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65	
28119074-6	2017	In contrast, celastrol effectively suppressed reactive oxygen species generation, improved endothelial cell activity, and ameliorated Ang II-mediated HUVEC injury through activation of Nrf2, inhibition of Nox2/AT1 receptor expression, and upregulated phosphorylation of ERK1/2.	celastrol	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189	
28119074-7	2017	After treatment with brusatol, a specific inhibitor of Nrf2, the protective effects of celastrol on Ang II-induced damage in HUVECs were remarkably alleviated.	celastrol	87-96	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59	
28119074-8	2017	Taken together, celastrol-induced activation of Nrf2 and inhibition of NADPH oxidase activity were critical for the inhibition of Ang II-mediated endothelial dysfunction, and demonstrated the potential application of celastrol in CVD therapy.	celastrol	16-25	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52	
28119074-8	2017	Taken together, celastrol-induced activation of Nrf2 and inhibition of NADPH oxidase activity were critical for the inhibition of Ang II-mediated endothelial dysfunction, and demonstrated the potential application of celastrol in CVD therapy.	celastrol	217-226	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52	
25064159-7	2014	Furthermore, celastrol induced mRNA and protein expression of HO-1 as well as Nrf2 activation.	celastrol	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82	
28119074-0	2017	Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway.	celastrol	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117	
21414301-5	2011	Celastrol induced Nrf2 activation.	celastrol	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22	
21414301-6	2011	Nrf2 knockdown using small interfering RNA (siRNA) inhibited celastrol-induced HO-1 expression.	celastrol	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4	
21414301-8	2011	Furthermore, Nrf2 siRNA significantly reversed the inhibitory effect of celastrol on IFN-gamma-induced expression of ICAM-1 in the keratinocytes.	celastrol	72-81	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17	
21414301-9	2011	Taken together, our results indicate that celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the up-regulation of HO-1 which is partly responsible for its anti-inflammatory activity in the keratinocytes.	celastrol	42-51	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85