PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26793111-7	2015	In addition, treatment with celastrol inhibited inflammatory responses, as indicated by the decrease of serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, down-regulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and inactivation of nuclear factor kappaB (NF-kappaB).	celastrol	28-37	nitric oxide synthase 2, inducible	Mus musculus	232-263	
26793111-7	2015	In addition, treatment with celastrol inhibited inflammatory responses, as indicated by the decrease of serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, down-regulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and inactivation of nuclear factor kappaB (NF-kappaB).	celastrol	28-37	nitric oxide synthase 2, inducible	Mus musculus	265-269	
23799016-5	2013	Celastrol also decreased IkappaB phosphorylation and degradation and reduced production of inducible nitric oxide synthase (iNOS), nitric oxide (NO) and proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and IL-6.	celastrol	0-9	nitric oxide synthase 2, inducible	Mus musculus	91-122	
23799016-5	2013	Celastrol also decreased IkappaB phosphorylation and degradation and reduced production of inducible nitric oxide synthase (iNOS), nitric oxide (NO) and proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and IL-6.	celastrol	0-9	nitric oxide synthase 2, inducible	Mus musculus	124-128	
16909005-8	2005	Celastrol treatment reduced TNF-alpha, iNOS, CD40, and GFAP immunoreactivity in the lumbar spinal cord sections of celastrol-treated G93A mice compared to untreated G93A mice.	celastrol	0-9	nitric oxide synthase 2, inducible	Mus musculus	39-43	
19508391-9	2009	CONCLUSION AND IMPLICATIONS: Our results indicate that, by preventing Jak2-dependent induction of iNOS and Nox1, tripterine inhibits peroxynitrite precursor synthesis, attenuates the increased activity of PP2A and consequently protects endothelial barrier function.	celastrol	113-123	nitric oxide synthase 2, inducible	Mus musculus	98-102	
29069290-3	2018	Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6 and IL-1beta.	celastrol	8-17	nitric oxide synthase 2, inducible	Mus musculus	202-233	
31454532-7	2019	As for macrophage M1/M2 polarization in liver, nano-celastrol reduced the expression of macrophage M1 biomarkers (e.g., IL-6, IL-1beta, TNF-alpha, iNOS) in a dose-dependent manner and marginally increased the expression of macrophage M2 biomarkers (e.g., Arg-1, IL-10).	celastrol	52-61	nitric oxide synthase 2, inducible	Mus musculus	147-151	
29069290-3	2018	Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6 and IL-1beta.	celastrol	8-17	nitric oxide synthase 2, inducible	Mus musculus	235-239	
29069290-6	2018	Celastrol chemoprevention of CAC in this new model of intestinal neoplasia was associated with significant suppression of iNOS at 4 months of age, and iNOS, COX-2 and NFkappaB at 6 months of age, with significant reduction in inflammatory cytokines, IL-6 and IL-1beta.	celastrol	0-9	nitric oxide synthase 2, inducible	Mus musculus	122-126	
29069290-6	2018	Celastrol chemoprevention of CAC in this new model of intestinal neoplasia was associated with significant suppression of iNOS at 4 months of age, and iNOS, COX-2 and NFkappaB at 6 months of age, with significant reduction in inflammatory cytokines, IL-6 and IL-1beta.	celastrol	0-9	nitric oxide synthase 2, inducible	Mus musculus	151-155	
29040966-5	2017	Celastrol down-regulated the mRNA levels of macrophage M1 biomarkers (e.g., IL-6, IL-1beta, TNF-alpha, iNOS) in cell culture and in mice.	celastrol	0-9	nitric oxide synthase 2, inducible	Mus musculus	103-107