PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16651429-7	2006	Inhibition of the proteasome activity by Celastrol in PC-3 (androgen receptor- or AR-negative) or LNCaP (AR-positive) cells results in the accumulation of ubiquitinated proteins and three natural proteasome substrates (IkappaB-alpha, Bax, and p27), accompanied by suppression of AR protein expression (in LNCaP cells) and induction of apoptosis.	celastrol	41-50	BCL2 associated X, apoptosis regulator	Homo sapiens	234-237	
11601243-9	1999	Tripterine could upregulate Bax, c-myc expression and downregulate bcl-2 expression at protein level.	celastrol	0-10	BCL2 associated X, apoptosis regulator	Homo sapiens	28-31	
12508653-7	2002	CONCLUSION: Triptolide and celastrol inhibit the proliferation of glioma cells in vitro, which was associated with promoting the expression of Bax and inhibiting the expression of Bcl-2 and accelerating cell apotosis.	celastrol	27-36	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146	
11601243-10	1999	CONCLUSION: Tripterine can efficiently induce HMC-1 cell apoptosis, occurring mainly in S phase, which is correlated with upregulating Bax, c-myc expression and downregulating bcl-2 expression.	celastrol	12-22	BCL2 associated X, apoptosis regulator	Homo sapiens	135-138	
30626478-5	2018	The effects of celastrol on the expression of BAX, B-cell lymphoma 2 (Bcl2), caspase-3, caspase-8, caspase-9 mRNA in A549 cells were detected by real-time quantitative PCR.	celastrol	15-24	BCL2 associated X, apoptosis regulator	Homo sapiens	46-49	
34000513-9	2021	RESULTS: Findings indicated that tripterine suppressed BC cells" viability, proliferation, migration, invasion capacity and Bcl-2 protein expression, but it induced BC cells" Bax protein expression.	celastrol	33-43	BCL2 associated X, apoptosis regulator	Homo sapiens	175-178	
31949255-13	2020	We are the first to identify the involvement of a cysteine metabolism/reactive oxygen species/p53/Bax/caspase 9/caspase 3 pathway in celastrol-triggered mitochondrial apoptosis in HL-60 and NB-4 cells, providing a novel underlying mechanism through which celastrol could be used to treat acute myeloid leukaemia, especially acute promyelocytic leukaemia.	celastrol	133-142	BCL2 associated X, apoptosis regulator	Homo sapiens	98-101	
30389635-6	2019	Celastrol induced apoptosis primarily via up-regulation of caspase-3, caspase-8, and Bax, and down-regulation of Bcl-2.	celastrol	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	85-88	
34256125-1	2021	A series of eleven celastrol derivatives was designed, synthesized, and evaluated for their in vitro cytotoxic activities against six human cancer cell lines (A549, HepG2, HepAD38, PC3, DLD-1 Bax-Bak WT and DKO) and three human normal cells (LO2, BEAS-2B, CCD19Lu).	celastrol	19-28	BCL2 associated X, apoptosis regulator	Homo sapiens	192-195	
30255683-6	2018	With the increase of the concentration of celastrol, the ratio of Bax/Bcl-2 protein was up-regulated.	celastrol	42-51	BCL2 associated X, apoptosis regulator	Homo sapiens	66-69	
29928421-10	2018	The downregulation of p-Akt and p-ERK induced by Apatinib and Tripterine was further inhibited in the combination group (P<0.05), and the expression levels of Caspase-3 and Bax were also significantly increased in the combination group (P<0.05).	celastrol	62-72	BCL2 associated X, apoptosis regulator	Homo sapiens	176-179	
29928421-11	2018	The combination of Apatinib and Tripterine significantly inhibited the proliferation, migration and invasion ability and promoted the apoptosis of Hep3B cells by downregulating the expression of p-Akt and p-ERK, and upregulating the expression of Caspase-3 and Bax.	celastrol	32-42	BCL2 associated X, apoptosis regulator	Homo sapiens	261-264	
26165547-10	2015	Furthermore, we observed that celastrol upregulated the expression of the pro-apoptotic proteins Bax and cytochrome c and altered the ratio of Bax/Bcl-2, and triggered the mitochondrial apoptotic pathway, resulting in caspase-3 and -9 activation and PARP cleavage.	celastrol	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	97-100	
28522217-7	2017	In addition, celastrol inhibited the expression of CIP2A, c-MYC, and suppressed apoptotic proteins BAX and caspase-8 in human CS cells, on the other hand, it induced the expression of antiapoptotic protein Bcl-2.	celastrol	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102	
29434967-6	2018	Celastrol may also decrease the phosphorylation levels of signal transducer and activator of transcription 3 (STAT3) and the B cell lymphoma-2 (Bcl-2)/Bcl-2 associated C protein (Bax) ratio.	celastrol	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	179-182	
26165547-10	2015	Furthermore, we observed that celastrol upregulated the expression of the pro-apoptotic proteins Bax and cytochrome c and altered the ratio of Bax/Bcl-2, and triggered the mitochondrial apoptotic pathway, resulting in caspase-3 and -9 activation and PARP cleavage.	celastrol	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146	
24214023-6	2014	Similarly, celastrol treatment inhibited cytochrome c release, Bax/Bcl-2 ratio changes, and caspase-9/3 activation.	celastrol	11-20	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66	
25818165-6	2015	Meanwhile, celastrol triggered reactive oxygen species production with collapse of mitochondrial membrane potential, down-regulation of Bcl-2 and up-regulation of Bax expression.	celastrol	11-20	BCL2 associated X, apoptosis regulator	Homo sapiens	163-166	
23846217-7	2013	Celastrol induced translocation of Bax into the mitochondria, which might be related to the upregulation of BH-3-only proteins such as BIM and the increase in the expression level of TOM22.	celastrol	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38	
22877649-10	2012	Beta-catenin siRNA significantly inhibited the expression of Bax and Bcl-2 in celastrol-treated HT29 cells.	celastrol	78-87	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64	
23711145-7	2013	Furthermore, celastrol dramatically increased expression of Bax/Bcl-2, proteolytic cleavage of Caspase-3, -9, PARP, and decreased expression of FasR.	celastrol	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63	
21951963-9	2011	In addition, western blot analysis revealed a significant augmentation in the protein expression of Bax and attenuation in Bcl-2, suggesting that the celastrol-induced apoptosis acts through both death receptor and mitochondrial pathways.	celastrol	150-159	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103	
21466843-9	2011	Celastrol also up-regulated the expression of pro-apoptotic Bax, down-regulated anti-apoptotic Bcl-2, and inhibited Akt phosphorylation.	celastrol	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63	
21134410-7	2011	In addition, celastrol decreased the expression of anti-apoptotic Bcl-2 protein and increased expression of pro-apoptotic Bax protein.	celastrol	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125