PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23065091-6 2012 Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF. celastrol 75-84 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 279-282 23065091-6 2012 Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF. celastrol 142-151 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 279-282 23065091-7 2012 Importantly, silencing of AIF by transfection of siAIF into cells remarkably attenuated celastrol-induced apoptotic cell death. celastrol 88-97 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 26-29